Reactive oxygen species and Alzheimer's disease.

[1]  M. Emmerling,et al.  Morphology and Toxicity of Aβ-(1-42) Dimer Derived from Neuritic and Vascular Amyloid Deposits of Alzheimer's Disease* , 1996, The Journal of Biological Chemistry.

[2]  X. Chen,et al.  RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease , 1996, Nature.

[3]  D. Selkoe,et al.  Amyloid β-Protein and the Genetics of Alzheimer's Disease* , 1996, The Journal of Biological Chemistry.

[4]  G. Schellenberg,et al.  Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease , 1996, Nature Medicine.

[5]  M. Beal,et al.  Oxidative damage in Alzheimer's , 1996, Nature.

[6]  E. Stadtman,et al.  A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[7]  B. Yankner Mechanisms of Neuronal Degeneration in Alzheimer's Disease , 1996, Neuron.

[8]  M. Mullan,et al.  β-Amyloid-mediated vasoactivity and vascular endothelial damage , 1996, Nature.

[9]  C. Masters,et al.  The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I) , 1996, Science.

[10]  M. Ball,et al.  Water-soluble A(N-40, N-42) Oligomers in Normal and Alzheimer Disease Brains (*) , 1996, The Journal of Biological Chemistry.

[11]  D. Bredesen,et al.  Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis , 1996, Science.

[12]  B. Yankner,et al.  Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro , 1995, Nature.

[13]  M. Mattson,et al.  Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[14]  P. Mantyh,et al.  Zinc and Alzheimer's disease. , 1995, Science.

[15]  D. Pollen,et al.  Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease , 1995, Nature.

[16]  D. Borchelt,et al.  An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria , 1995, Neuron.

[17]  E. Ikonen,et al.  Intracellular routing of human amyloid protein precursor: Axonal delivery followed by transport to the dendrites , 1995, Journal of neuroscience research.

[18]  W. E. Nostrand Zinc (II) selectively enhances the inhibition of coagulation factor XIa by protease nexin-2/amyloid β-Protein precursor , 1995 .

[19]  Mark A. Smith,et al.  Radical AGEing in Alzheimer's disease , 1995, Trends in Neurosciences.

[20]  Robert H. Brown,et al.  Amyotrophic lateral sclerosis: Recent insights from genetics and transgenic mice , 1995, Cell.

[21]  D. Mann,et al.  Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down Syndrome , 1995, Annals of neurology.

[22]  S. Sisodia,et al.  Nucleotide sequence of the chromosome 14-encoded S182 cDNA and revised secondary structure prediction , 1995 .

[23]  M. Mattson Calcium and Neuronal Injury in Alzheimer's Disease , 1994, Annals of the New York Academy of Sciences.

[24]  C. Masters,et al.  Interaction between the zinc(II) and the heparin binding site of the Alzheimer's disease βA4 amyloid precursor protein (APP) , 1994, FEBS letters.

[25]  C. Masters,et al.  Rapid induction of Alzheimer A beta amyloid formation by zinc. , 1994, Science.

[26]  C. Masters,et al.  The βA4 amyloid precursor protein binding to copper , 1994 .

[27]  T. Iwatsubo,et al.  Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43) , 1994, Neuron.

[28]  C. Behl,et al.  Hydrogen peroxide mediates amyloid β protein toxicity , 1994, Cell.

[29]  M. Gurney,et al.  Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. , 1994, Science.

[30]  S. Younkin,et al.  An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. , 1994, Science.

[31]  C. Behl,et al.  Amyloid β peptide induces necrosis rather than apoptosis , 1994, Brain Research.

[32]  M. Mattson,et al.  A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[33]  L. Iversen,et al.  Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[34]  G. Multhaup Identification and regulation of the high affinity binding site of the Alzheimer's disease amyloid protein precursor (APP) to glycosaminoglycans. , 1994, Biochimie.

[35]  K. Beyreuther,et al.  Generation of βA4 from the amyloid protein precursor and fragments thereof , 1993 .

[36]  G. Kreutzberg,et al.  Early and rapid de novo synthesis of Alzheimer βA4‐Amyloid precursor protein (APP) in activated microglia , 1993, Glia.

[37]  Z. Oltvai,et al.  Bcl-2 functions in an antioxidant pathway to prevent apoptosis , 1993, Cell.

[38]  B. Yankner,et al.  β‐Amyloid Neurotoxicity in Human Cortical Culture Is Not Mediated by Excitotoxins , 1993, Journal of neurochemistry.

[39]  C. Cotman,et al.  Cultured GABA-immunoreactive neurons are resistant to toxicity induced by β-amyloid , 1993, Neuroscience.

[40]  C. Cotman,et al.  Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[41]  P. Mantyh,et al.  Aluminum, Iron, and Zinc Ions Promote Aggregation of Physiological Concentrations of β‐Amyloid Peptide , 1993, Journal of neurochemistry.

[42]  M. Pericak-Vance,et al.  Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. , 1993, Science.

[43]  C. Masters,et al.  A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease. , 1993, The Journal of biological chemistry.

[44]  H. Sies Strategies of antioxidant defense , 1993 .

[45]  P. Lansbury,et al.  Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie? , 1993, Cell.

[46]  P. Lansbury,et al.  The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. , 1993, Biochemistry.

[47]  J. Haines,et al.  Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis , 1993, Nature.

[48]  S. Younkin,et al.  Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. , 1993, Science.

[49]  D. Selkoe,et al.  Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production , 1992, Nature.

[50]  H. Maeda,et al.  Hydroxyl radical production by H2O2 plus Cu,Zn-superoxide dismutase reflects the activity of free copper released from the oxidatively damaged enzyme. , 1992, The Journal of biological chemistry.

[51]  S. Estus,et al.  Production of the Alzheimer amyloid beta protein by normal proteolytic processing. , 1992, Science.

[52]  D. Selkoe,et al.  Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids , 1992, Nature.

[53]  D. Selkoe,et al.  Amyloid β-peptide is produced by cultured cells during normal metabolism , 1992, Nature.

[54]  K. Beyreuther,et al.  Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation. , 1992, The Journal of biological chemistry.

[55]  B. Winblad,et al.  A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid , 1992, Nature Genetics.

[56]  B. Halliwell,et al.  Biologically relevant metal ion‐dependent hydroxyl radical generation An update , 1992, FEBS letters.

[57]  Y. Komiyama,et al.  Purification of factor XIa inhibitor from human platelets. , 1992, Thrombosis research.

[58]  M. Mattson,et al.  beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[59]  C. Cotman,et al.  β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease , 1992, Brain Research.

[60]  C. Cotman,et al.  Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs. , 1992, The Journal of biological chemistry.

[61]  A. Hofman,et al.  Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene , 1992, Nature Genetics.

[62]  W. Markesbery,et al.  Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[63]  J. Hardy,et al.  Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene , 1991, Nature.

[64]  S. Tsuji,et al.  Mis-sense mutation Val→Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease , 1991, The Lancet.

[65]  M. Pericak-Vance,et al.  Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease , 1991, Nature.

[66]  B. Winblad,et al.  Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease. , 1991, Journal of neural transmission. Parkinson's disease and dementia section.

[67]  D. Kirschner,et al.  Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. , 1990, Science.

[68]  B. Freeman,et al.  Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[69]  B. Halliwell,et al.  Role of free radicals and catalytic metal ions in human disease: an overview. , 1990, Methods in enzymology.

[70]  R. Martins,et al.  Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. , 1989, The New England journal of medicine.

[71]  K. Davies,et al.  Macroxyproteinase (M.O.P.): a 670 kDa proteinase complex that degrades oxidatively denatured proteins in red blood cells. , 1989, Free radical biology & medicine.

[72]  S. W. Lin,et al.  Mitochondria contain a proteolytic system which can recognize and degrade oxidatively-denatured proteins. , 1988, The Biochemical journal.

[73]  M. Lovett,et al.  Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[74]  K. Davies,et al.  Protein damage and degradation by oxygen radicals. III. Modification of secondary and tertiary structure. , 1987, The Journal of biological chemistry.

[75]  S. W. Lin,et al.  Protein damage and degradation by oxygen radicals. IV. Degradation of denatured protein. , 1987, The Journal of biological chemistry.

[76]  R. Martins,et al.  Increased Cerebral Glucose‐6‐Phosphate Dehydrogenase Activity in Alzheimer's Disease May Reflect Oxidative Stress , 1986, Journal of neurochemistry.

[77]  K. Asada,et al.  Superoxide anion permeability of phospholipid membranes and chloroplast thylakoids. , 1983, Archives of biochemistry and biophysics.

[78]  L. Hershey,et al.  Cerebrospinal fluid trace element content in dementia , 1983, Neurology.

[79]  B Chance,et al.  Hydroperoxide metabolism in mammalian organs. , 1979, Physiological reviews.

[80]  I. Fridovich,et al.  Permeation of the erythrocyte stroma by superoxide radical. , 1978, The Journal of biological chemistry.

[81]  J. Brody,et al.  Familial motor neuron disease , 1976, Neurology.

[82]  I. Fridovich,et al.  The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: inactivation of the enzyme. , 1975, Biochemistry.