Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance
暂无分享,去创建一个
Regina S. Salvat | C. Bailey-Kellogg | S. Fiering | B. Berwin | K. Griswold | J. Fields | Yoonjoo Choi | L. Moise | Daniel C. Osipovitch | Kristina Blazanovic | H. Zhao | Wen Li | Hongliang Zhao
[1] Ben M. Webb,et al. Comparative Protein Structure Modeling Using MODELLER , 2016, Current protocols in bioinformatics.
[2] Chris Bailey-Kellogg,et al. Protein deimmunization via structure‐based design enables efficient epitope deletion at high mutational loads , 2015, Biotechnology and bioengineering.
[3] Chris Bailey-Kellogg,et al. Mapping the Pareto Optimal Design Space for a Functionally Deimmunized Biotherapeutic Candidate , 2015, PLoS Comput. Biol..
[4] H. Spits,et al. Critical assessment of human antibody generation in humanized mouse models. , 2014, Journal of immunological methods.
[5] Andrew S. Parker,et al. Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate , 2014, Cellular and Molecular Life Sciences.
[6] David Baker,et al. Removing T-cell epitopes with computational protein design , 2014, Proceedings of the National Academy of Sciences.
[7] D. Baker,et al. Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes , 2014, Proceedings of the National Academy of Sciences.
[8] Chris Bailey-Kellogg,et al. A high throughput MHC II binding assay for quantitative analysis of peptide epitopes. , 2014, Journal of visualized experiments : JoVE.
[9] Chris Bailey-Kellogg,et al. Gene and Protein Sequence Optimization for High-Level Production of Fully Active and Aglycosylated Lysostaphin in Pichia pastoris , 2014, Applied and Environmental Microbiology.
[10] Vibha Jawa,et al. T-cell dependent immunogenicity of protein therapeutics: Preclinical assessment and mitigation. , 2013, Clinical immunology.
[11] Raymond Schuch,et al. Lysins: the arrival of pathogen-directed anti-infectives. , 2013, Journal of medical microbiology.
[12] C M Macal,et al. The economic burden of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). , 2013, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
[13] M. Schmelcher,et al. Chimeric Ply187 endolysin kills Staphylococcus aureus more effectively than the parental enzyme. , 2013, FEMS microbiology letters.
[14] David L. Smith,et al. The changing epidemiology of methicillin-resistant Staphylococcus aureus in the United States: a national observational study. , 2013, American journal of epidemiology.
[15] Lorena Rodríguez-Rubio,et al. Potential of the Virion-Associated Peptidoglycan Hydrolase HydH5 and Its Derivative Fusion Proteins in Milk Biopreservation , 2013, PloS one.
[16] G. Guebitz,et al. Antimicrobial enzymes: An emerging strategy to fight microbes and microbial biofilms , 2013, Biotechnology journal.
[17] R. Kotłowski,et al. Peptidoglycan hydrolases-potential weapons against Staphylococcus aureus , 2012, Applied Microbiology and Biotechnology.
[18] Chris Bailey-Kellogg,et al. Design and analysis of immune-evading enzymes for ADEPT therapy. , 2012, Protein engineering, design & selection : PEDS.
[19] Chris Bailey-Kellogg,et al. Structure-Guided Deimmunization of Therapeutic Proteins , 2012, RECOMB.
[20] J. Raj,et al. Antistaphylococcal activity of bacteriophage derived chimeric protein P128 , 2012, BMC Microbiology.
[21] Chris Bailey-Kellogg,et al. A divide‐and‐conquer approach to determine the Pareto frontier for optimization of protein engineering experiments , 2012, Proteins.
[22] George Georgiou,et al. Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift , 2011, Proceedings of the National Academy of Sciences.
[23] Marco Biasini,et al. Toward the estimation of the absolute quality of individual protein structure models , 2010, Bioinform..
[24] Chad W. Euler,et al. A Novel Chimeric Lysin Shows Superiority to Mupirocin for Skin Decolonization of Methicillin-Resistant and -Sensitive Staphylococcus aureus Strains , 2010, Antimicrobial Agents and Chemotherapy.
[25] Yoonjoo Choi,et al. FREAD revisited: Accurate loop structure prediction using a database search algorithm , 2010, Proteins.
[26] Chad W. Euler,et al. Synergism between a Novel Chimeric Lysin and Oxacillin Protects against Infection by Methicillin-Resistant Staphylococcus aureus , 2010, Antimicrobial Agents and Chemotherapy.
[27] Paul D. R. Johnson,et al. Reduced Vancomycin Susceptibility in Staphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications , 2010, Clinical Microbiology Reviews.
[28] D. Nathwani,et al. MRSA as a cause of lung infection including airway infection, community-acquired pneumonia and hospital-acquired pneumonia , 2009, European Respiratory Journal.
[29] Roland L. Dunbrack,et al. proteins STRUCTURE O FUNCTION O BIOINFORMATICS Improved prediction of protein side-chain conformations with SCWRL4 , 2022 .
[30] A. Pantosti,et al. What is MRSA? , 2009, European Respiratory Journal.
[31] J. Cizeau,et al. Engineering and Biological Characterization of VB6-845, an Anti-EpCAM Immunotoxin Containing a T-cell Epitope-depleted Variant of the Plant Toxin Bouganin , 2009, Journal of immunotherapy.
[32] Mamoru Ito,et al. The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice). , 2009, International immunology.
[33] Andrew D. Luster,et al. Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice , 2009, Journal of Virology.
[34] Amy C. Anderson,et al. Computational structure-based redesign of enzyme activity , 2009, Proceedings of the National Academy of Sciences.
[35] Gary Taubes,et al. The Bacteria Fight Back , 2008, Science.
[36] M. Sykes,et al. Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. , 2008, Blood.
[37] Anne S De Groot,et al. Immunogenicity of protein therapeutics. , 2007, Trends in immunology.
[38] F. Niesen,et al. The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability , 2007, Nature Protocols.
[39] T. Jones,et al. Identification and removal of immunogenicity in therapeutic proteins. , 2007, Current opinion in drug discovery & development.
[40] V. Hornak,et al. Comparison of multiple Amber force fields and development of improved protein backbone parameters , 2006, Proteins.
[41] A. Sali,et al. Statistical potential for assessment and prediction of protein structures , 2006, Protein science : a publication of the Protein Society.
[42] J. Boyce,et al. Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat , 2006, The Lancet.
[43] S. Depil,et al. Peptide-binding assays and HLA II transgenic Abeta degrees mice are consistent and complementary tools for identifying HLA II-restricted peptides. , 2006, Vaccine.
[44] M. Bochtler,et al. Crystal structures of active LytM. , 2005, Journal of molecular biology.
[45] Wolfgang Aehle,et al. A β-lactamase with reduced immunogenicity for the targeted delivery of chemotherapeutics using antibody-directed enzyme prodrug therapy , 2005, Molecular Cancer Therapeutics.
[46] Bruno Hoen,et al. Staphylococcus aureus endocarditis: a consequence of medical progress. , 2005, JAMA.
[47] T. Baglin,et al. Identification and removal of a promiscuous CD4+ T cell epitope from the C1 domain of factor VIII , 2005, Journal of thrombosis and haemostasis : JTH.
[48] R. Wenzel,et al. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[49] S. Walsh,et al. Improved Pharmacokinetics and Reduced Antibody Reactivity of Lysostaphin Conjugated to Polyethylene Glycol , 2003, Antimicrobial Agents and Chemotherapy.
[50] A. Jevnikar,et al. The relationship between predicted peptide–MHC class II affinity and T-cell activation in a HLA-DRβ1*0401 transgenic mouse model , 2002, Arthritis research & therapy.
[51] John Sidney,et al. The HLA Molecules DQA1*0501/B1*0201 and DQA1*0301/B1*0302 Share an Extensive Overlap in Peptide Binding Specificity1 , 2002, The Journal of Immunology.
[52] Molecular therapy , 2002, Journal of the Neurological Sciences.
[53] Marc De Maeyer,et al. Elimination of a Human T-cell Region in Staphylokinase by T-cell Screening and Computer Modeling , 2002, Thrombosis and Haemostasis.
[54] A. D. De Groot,et al. Prediction of well-conserved HIV-1 ligands using a matrix-based algorithm, EpiMatrix. , 1998, Vaccine.
[55] M F del Guercio,et al. Several common HLA-DR types share largely overlapping peptide binding repertoires. , 1998, Journal of immunology.
[56] Thomas L. Madden,et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. , 1997, Nucleic acids research.
[57] F. Falcioni,et al. HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis , 1996, The Journal of experimental medicine.
[58] Peter A. Kollman,et al. AMBER, a package of computer programs for applying molecular mechanics, normal mode analysis, molecular dynamics and free energy calculations to simulate the structural and energetic properties of molecules , 1995 .
[59] W. C. Still,et al. Semianalytical treatment of solvation for molecular mechanics and dynamics , 1990 .
[60] K. Griswold,et al. Fusion with a cell wall binding domain renders autolysin LytM a potent anti-Staphylococcus aureus agent. , 2015, FEMS microbiology letters.
[61] J. Klumpp,et al. Endolysins as antimicrobials. , 2012, Advances in virus research.
[62] E. Mylonakis,et al. Lysostaphin: a silver bullet for staph. , 2012 .
[63] Ira Mellman,et al. Cell biology of antigen processing in vitro and in vivo. , 2005, Annual review of immunology.
[64] P Argos,et al. Oligopeptide biases in protein sequences and their use in predicting protein coding regions in nucleotide sequences , 1988, Proteins.