Electroacupuncture ameliorates cerebrovascular impairment in Alzheimer's disease mice via melatonin signaling

Cerebrovascular impairment contributes to the pathogenesis of Alzheimer's disease (AD). However, it still lacks effective intervention in clinical practice. Here, we investigated the efficacy of electroacupuncture (EA) in cerebrovascular repair in 3xTg‐AD mice and its mechanism.

[1]  Nenggui Xu,et al.  High-fidelity imaging of amyloid-beta deposits with an ultrasensitive fluorescent probe facilitates the early diagnosis and treatment of Alzheimer's Disease , 2022, Theranostics.

[2]  G. Guyatt,et al.  Evidence on acupuncture therapies is underused in clinical practice and health policy , 2022, BMJ.

[3]  N. Nishimura,et al.  VEGF signalling causes stalls in brain capillaries and reduces cerebral blood flow in Alzheimer’s mice , 2022, Brain : a journal of neurology.

[4]  Xin Li,et al.  In Situ Imaging of Formaldehyde in Live Mice with High Spatiotemporal Resolution Reveals Aldehyde Dehydrogenase-2 as a Potential Target for Alzheimer's Disease Treatment. , 2021, Analytical chemistry.

[5]  Ashutosh Kumar Singh,et al.  Therapeutic Potential of Vital Transcription Factors in Alzheimer’s and Parkinson’s Disease With Particular Emphasis on Transcription Factor EB Mediated Autophagy , 2021, Frontiers in Neuroscience.

[6]  Jian-Zhi Wang,et al.  Biomarkers used in Alzheimer’s disease diagnosis, treatment, and prevention , 2021, Ageing Research Reviews.

[7]  Yang-shuai Su,et al.  A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis , 2021, Nature.

[8]  Xifei Yang,et al.  Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer’s disease , 2021, Journal of pineal research.

[9]  L. Giménez-Llort,et al.  Olfactory Signatures in the Food Finding Test in Mice With Normal and Alzheimer’s Disease-Pathological Aging With Special Concerns on the Effects of Social Isolation , 2021, Frontiers in Neuroscience.

[10]  N. Simmons-Stern,et al.  The costs of developing treatments for Alzheimer's disease: A retrospective exploration , 2021, Alzheimer's & dementia : the journal of the Alzheimer's Association.

[11]  Cun-Zhi Liu,et al.  Effectiveness and Safety of Acupuncture for Vascular Cognitive Impairment: A Systematic Review and Meta-Analysis , 2021, Frontiers in Aging Neuroscience.

[12]  D. Chellappan,et al.  Therapeutic Potential of Phytoconstituents in Management of Alzheimer's Disease , 2021, Evidence-based complementary and alternative medicine : eCAM.

[13]  Mikko T. Huuskonen,et al.  APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-β , 2021, Nature Aging.

[14]  C. Hsieh,et al.  Effects of Acupuncture on Oxidative Stress Amelioration via Nrf2/ARE-Related Pathways in Alzheimer and Parkinson Diseases , 2021, Evidence-based complementary and alternative medicine : eCAM.

[15]  R. Roman,et al.  Reversal of cerebral hypoperfusion: a novel therapeutic target for the treatment of AD/ADRD? , 2021, GeroScience.

[16]  Xifei Yang,et al.  Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB) , 2021, Autophagy.

[17]  Cun-Zhi Liu,et al.  Electroacupuncture ameliorates intestinal inflammation by activating α7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus , 2021, Theranostics.

[18]  Q. Ma,et al.  Somato-Autonomic Reflexes of Acupuncture. , 2020, Medical acupuncture.

[19]  J. Ghiso,et al.  Alzheimer’s amyloid β heterogeneous species differentially affect brain endothelial cell viability, blood‐brain barrier integrity, and angiogenesis , 2020, Aging cell.

[20]  S. Reeves,et al.  The Relationship Between Anxiety and Incident Agitation in Alzheimer's Disease. , 2020, Journal of Alzheimer's disease : JAD.

[21]  G. Guyatt,et al.  Anti-Aβ agents for mild to moderate Alzheimer's disease: systematic review and meta-analysis , 2020, Journal of Neurology, Neurosurgery, and Psychiatry.

[22]  Russell S. Ray,et al.  Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture , 2020, Neuron.

[23]  M. Vossoughi,et al.  Effect of Acupuncture on Pregnancy-Related Insomnia and Melatonin: A Single-Blinded, Randomized, Placebo-Controlled Trial , 2020, Nature and science of sleep.

[24]  Xiao Zhen Zhou,et al.  Melatonin Directly Binds and Inhibits Death-Associated Protein Kinase 1 Function in Alzheimer's Disease. , 2020, Journal of pineal research.

[25]  P. Govitrapong,et al.  Melatonin receptor as a drug target for neuroprotection. , 2020, Current molecular pharmacology.

[26]  A. Fagan,et al.  APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline , 2020, Nature.

[27]  Mei Han,et al.  Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia , 2020, Theranostics.

[28]  Jun-Hwan Lee,et al.  Electroacupuncture attenuates cognition impairment via anti-neuroinflammation in an Alzheimer’s disease animal model , 2019, Journal of Neuroinflammation.

[29]  Juhyun Song.  Pineal gland dysfunction in Alzheimer’s disease: relationship with the immune-pineal axis, sleep disturbance, and neurogenesis , 2019, Molecular Neurodegeneration.

[30]  M. Schwab,et al.  Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke , 2019, Proceedings of the National Academy of Sciences.

[31]  Md. Farhad Hossain,et al.  Melatonin in Alzheimer’s Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer’s Neuropathology , 2019, Molecular Neurobiology.

[32]  Max I Bogorad,et al.  Cerebrovascular plasticity: Processes that lead to changes in the architecture of brain microvessels , 2019, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[33]  Yundai Chen,et al.  Melatonin attenuates myocardial ischemia‐reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK‐OPA1 signaling pathways , 2019, Journal of pineal research.

[34]  Eric E. Smith,et al.  Vascular dysfunction—The disregarded partner of Alzheimer's disease , 2019, Alzheimer's & Dementia.

[35]  C. Murphy.  Olfactory and other sensory impairments in Alzheimer disease , 2018, Nature Reviews Neurology.

[36]  L. Grinberg,et al.  Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer's Disease. , 2018, Journal of Alzheimer's disease : JAD.

[37]  Y. Wang,et al.  High-frequency (50 Hz) electroacupuncture ameliorates cognitive impairment in rats with amyloid beta 1–42-induced Alzheimer's disease , 2018, Neural regeneration research.

[38]  H. Flyvbjerg,et al.  Contributions of the glycocalyx, endothelium, and extravascular compartment to the blood–brain barrier , 2018, Proceedings of the National Academy of Sciences.

[39]  Zhaojun Wang,et al.  Sex Differences in Neuropathology and Cognitive Behavior in APP/PS1/tau Triple-Transgenic Mouse Model of Alzheimer’s Disease , 2018, Neuroscience Bulletin.

[40]  Traynor,et al.  Melatonin receptor type 1A gene linked to Alzheimer’s disease in old age , 2018, Sleep.

[41]  Berislav V. Zlokovic,et al.  Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders , 2018, Nature Reviews Neurology.

[42]  Yang Zhang,et al.  Electroacupuncture improves neurovascular unit reconstruction by promoting collateral circulation and angiogenesis , 2017, Neural regeneration research.

[43]  K. Fukunaga,et al.  Melatonin ameliorates hypoglycemic stress‐induced brain endothelial tight junction injury by inhibiting protein nitration of TP53‐induced glycolysis and apoptosis regulator , 2017, Journal of pineal research.

[44]  Oxana V. Baranova,et al.  Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release , 2017, Proceedings of the National Academy of Sciences.

[45]  Cun-Zhi Liu,et al.  Mechanisms of acupuncture on vascular dementia—A review of animal studies , 2017, Neurochemistry International.

[46]  Yong Huang,et al.  Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study , 2017, Neural regeneration research.

[47]  Axel Montagne,et al.  Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease , 2017, Nature Reviews Neuroscience.

[48]  T. Yi,et al.  Electro-Acupuncture at Zusanli Acupoint (ST36) Suppresses Inflammation in Allergic Contact Dermatitis Via Triggering Local IL-10 Production and Inhibiting p38 MAPK Activation , 2017, Inflammation.

[49]  R. Delorme,et al.  Melatonin: Pharmacology, Functions and Therapeutic Benefits , 2017, Current neuropharmacology.

[50]  Wen-zhi Li,et al.  Electroacupuncture brain protection during ischemic stroke: A role for the parasympathetic nervous system , 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[51]  Norbert Schuff,et al.  Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis , 2016, Nature Communications.

[52]  David A. Bennett,et al.  Relation of Cerebral Vessel Disease to Alzheimer’s Disease Dementia and Cognitive Function in Older Persons: A Cross-sectional Study , 2016, The Lancet Neurology.

[53]  C. Jack,et al.  Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria , 2016, Alzheimer's & Dementia.

[54]  R. Tao,et al.  Visualizing peroxynitrite fluxes in endothelial cells reveals the dynamic progression of brain vascular injury. , 2015, Journal of the American Chemical Society.

[55]  Timothy J. Hohman,et al.  The role of vascular endothelial growth factor in neurodegeneration and cognitive decline: exploring interactions with biomarkers of Alzheimer disease. , 2015, JAMA neurology.

[56]  Yiwen Ruan,et al.  Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment , 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[57]  K. Fukunaga,et al.  Nitrosative stress induces peroxiredoxin 1 ubiquitination during ischemic insult via E6AP activation in endothelial cells both in vitro and in vivo. , 2014, Antioxidants & redox signaling.

[58]  K. Fukunaga,et al.  Ischemic injury promotes Keap1 nitration and disturbance of antioxidative responses in endothelial cells: a potential vasoprotective effect of melatonin , 2013, Journal of pineal research.

[59]  T. Miyakawa,et al.  Elevated Plus Maze for Mice , 2008, Journal of visualized experiments : JoVE.

[60]  C. Shapiro,et al.  Acupuncture increases nocturnal melatonin secretion and reduces insomnia and anxiety: a preliminary report. , 2004, The Journal of neuropsychiatry and clinical neurosciences.

[61]  Xiao-Min Wang,et al.  Long-term high-frequency electro-acupuncture stimulation prevents neuronal degeneration and up-regulates BDNF mRNA in the substantia nigra and ventral tegmental area following medial forebrain bundle axotomy. , 2002, Brain research. Molecular brain research.

[62]  OUP accepted manuscript , 2021, Brain.

[63]  Z. Tan,et al.  UC Irvine UC Irvine Previously Published Works Title Use of labeled tomato lectin for imaging vasculature structures , 2015 .

[64]  Sterling C. Johnson,et al.  Effects of hypoperfusion in Alzheimer's disease. , 2011, Journal of Alzheimer's disease : JAD.