Increased expression of CSF1 in patients with eosinophilic asthma

The link between colony‐stimulating factor 1 (CSF1) and asthma was reported recently. However, the role and mechanism of CSF1 in asthma remain poorly understood. In this study, we aimed to explore the expression and its potential mechanism of CSF1 in asthma.

[1]  Heng Li,et al.  Interfering with alternatively activated macrophages by CSF-1R inhibition exerts therapeutic capacity on allergic airway inflammation. , 2022, Biochemical pharmacology.

[2]  M. Grayson,et al.  Corticosteroid insensitivity persists in the absence of STAT1 signaling in severe allergic airway inflammation , 2021, American journal of physiology. Lung cellular and molecular physiology.

[3]  P. Ordentlich Clinical evaluation of colony-stimulating factor 1 receptor inhibitors. , 2021, Seminars in immunology.

[4]  Rachel E. Brewer,et al.  Aged skeletal stem cells generate an inflammatory degenerative niche , 2021, Nature.

[5]  Lisha Xiao,et al.  Increased MMP12 mRNA expression in induced sputum was correlated with airway eosinophilic inflammation in asthma patients: evidence from bioinformatic analysis and experiment verification. , 2021, Gene.

[6]  Jivianne T. Lee,et al.  Insights into the Implications of Coexisting Type 2 Inflammatory Diseases , 2021, Journal of inflammation research.

[7]  C. Akdis,et al.  Cellular and molecular mechanisms of allergic asthma. , 2021, Molecular aspects of medicine.

[8]  N. Galwey,et al.  Blood eosinophil counts in the general population and airways disease: a comprehensive review and meta-analysis , 2021, European Respiratory Journal.

[9]  Xiaofeng Yang,et al.  Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism , 2021, Frontiers in Immunology.

[10]  Dave Singh,et al.  Type‐2 airway inflammation in mild asthma patients with high blood eosinophils and high fractional exhaled nitric oxide , 2021, Clinical and translational science.

[11]  S. Gan,et al.  Traditional Medicinal Plants Conferring Protection Against Ovalbumin-Induced Asthma in Experimental Animals: A Review , 2021, Journal of Asthma and Allergy.

[12]  C. Porsbjerg,et al.  Treating severe asthma: Targeting the IL‐5 pathway , 2021, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[13]  H. Hammad,et al.  The basic immunology of asthma , 2021, Cell.

[14]  N. Ashley,et al.  Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype , 2021, Frontiers in Immunology.

[15]  John H. Zhang,et al.  Rh-CSF1 Attenuates Oxidative Stress and Neuronal Apoptosis via the CSF1R/PLCG2/PKA/UCP2 Signaling Pathway in a Rat Model of Neonatal HIE , 2020, Oxidative medicine and cellular longevity.

[16]  O. Butovsky,et al.  CSF1R signaling is a regulator of pathogenesis in progressive MS , 2020, Cell Death & Disease.

[17]  D. Wang,et al.  Role of IL‐25, IL‐33, and TSLP in triggering united airway diseases toward type 2 inflammation , 2020, Allergy.

[18]  M. Högman,et al.  Clinical Values of Nitric Oxide Parameters from the Respiratory System. , 2020, Current medicinal chemistry.

[19]  J. Christman,et al.  Colony‐stimulating factor 1 and its receptor are new potential therapeutic targets for allergic asthma , 2020, Allergy.

[20]  Kelli L Boyd,et al.  TSLP and IL‐33 reciprocally promote each other's lung protein expression and ILC2 receptor expression to enhance innate type‐2 airway inflammation , 2020, Allergy.

[21]  P. Korošec,et al.  Elevated eosinophils, IL5 and IL8 in induced sputum in asthma patients with accelerated FEV1 decline. , 2020, Respiratory medicine.

[22]  L. Wood,et al.  Sputum transcriptomics implicates increased p38 signalling activity in severe asthma , 2019, Respirology.

[23]  L. Carlin,et al.  Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocyte–dendritic cell antigen presentation , 2019, Science Immunology.

[24]  A. Kulkarni,et al.  CSF1R‐ and SHP2‐Inhibitor‐Loaded Nanoparticles Enhance Cytotoxic Activity and Phagocytosis in Tumor‐Associated Macrophages , 2019, Advanced materials.

[25]  R. Gerth van Wijk,et al.  Toward clinically applicable biomarkers for asthma: An EAACI position paper , 2019, Allergy.

[26]  D. Danilenko,et al.  Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer , 2019, Front. Immunol..

[27]  L. Wood,et al.  Dysregulation of sputum columnar epithelial cells and products in distinct asthma phenotypes , 2019, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[28]  A. Kato Group 2 Innate Lymphoid Cells in Airway Diseases. , 2019, Chest.

[29]  C. Jenkins,et al.  A sputum 6-gene signature predicts future exacerbations of poorly controlled asthma. , 2019, The Journal of allergy and clinical immunology.

[30]  G. Dranoff,et al.  GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation. , 2019, Immunity.

[31]  H. Hammad,et al.  The Cytokines of Asthma. , 2019, Immunity.

[32]  S. Snapper,et al.  STAT1 signaling shields T cells from NK cell-mediated cytotoxicity , 2019, Nature Communications.

[33]  M. Pijnenburg The Role of FeNO in Predicting Asthma , 2019, Front. Pediatr..

[34]  P. Wark,et al.  Mechanisms and Management of Asthma Exacerbations , 2019, American journal of respiratory and critical care medicine.

[35]  K. Nakagome,et al.  Involvement and Possible Role of Eosinophils in Asthma Exacerbation , 2018, Front. Immunol..

[36]  J. Christman,et al.  Airway Epithelial Cell‐Derived Colony Stimulating Factor‐1 Promotes Allergen Sensitization , 2018, Immunity.

[37]  J. Guiot,et al.  Methodology for Sputum Induction and Laboratory Processing. , 2017, Journal of visualized experiments : JoVE.

[38]  Oliver N Keene,et al.  Biomarkers for severe eosinophilic asthma , 2017, The Journal of allergy and clinical immunology.

[39]  K. Samitas,et al.  Innate immunity as the orchestrator of allergic airway inflammation and resolution in asthma. , 2017, International immunopharmacology.

[40]  M. Kubo Innate and adaptive type 2 immunity in lung allergic inflammation , 2017, Immunological reviews.

[41]  L. Wood,et al.  A sputum gene expression signature predicts oral corticosteroid response in asthma , 2017, European Respiratory Journal.

[42]  C. Auffray,et al.  T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED , 2017, European Respiratory Journal.

[43]  L. Calzà,et al.  Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis , 2016, Journal of Neuroinflammation.

[44]  B. Trapnell,et al.  Epidermal growth factor receptor signalling regulates granulocyte–macrophage colony‐stimulating factor production by airway epithelial cells and established allergic airway disease , 2016, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[45]  J. DeVoss,et al.  Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response , 2015, Science Signaling.

[46]  T. Usui,et al.  Pivotal Roles of GM-CSF in Autoimmunity and Inflammation , 2015, Mediators of inflammation.

[47]  E. Stanley,et al.  CSF-1 receptor signaling in myeloid cells. , 2014, Cold Spring Harbor perspectives in biology.

[48]  L. Wood,et al.  Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes. , 2014, The Journal of allergy and clinical immunology.

[49]  S. Holgate Innate and adaptive immune responses in asthma , 2012, Nature Medicine.

[50]  D. Hume,et al.  Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. , 2012, Blood.

[51]  B. Becher,et al.  RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation , 2011, Nature Immunology.

[52]  L. Punzi,et al.  Molecular pathways involved in synovial cell inflammation and tumoral proliferation in diffuse pigmented villonodular synovitis. , 2010, Autoimmunity reviews.

[53]  B. Romero-Romero,et al.  Relationship of the Asthma Control Test (ACT) with Lung Function, Levels of Exhaled Nitric Oxide and Control According to the Global Initiative for Asthma (GINA) , 2010 .

[54]  H. Shin,et al.  Association between colony-stimulating factor 1 receptor gene polymorphisms and asthma risk , 2010, Human Genetics.

[55]  Angel F. Lopez,et al.  The IL-3/IL-5/GM-CSF Common β Receptor Plays a Pivotal Role in the Regulation of Th2 Immunity and Allergic Airway Inflammation1 , 2008, The Journal of Immunology.

[56]  J. Drazen,et al.  Differentiation-dependent responsiveness of bronchial epithelial cells to IL-4/13 stimulation. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[57]  S. Ebong,et al.  Dendritic Cell Maturation Requires STAT1 and Is under Feedback Regulation by Suppressors of Cytokine Signaling , 2004, The Journal of Immunology.

[58]  M. Jordana,et al.  On the generation of allergic airway diseases: from GM-CSF to Kyoto. , 2002, Trends in immunology.

[59]  H. Mukae,et al.  Interleukin 5 and granulocyte-macrophage colony-stimulating factor levels in bronchoalveolar lavage fluid in interstitial lung disease. , 2000, The European respiratory journal.

[60]  Y. Gon,et al.  Role of airway epithelial barrier dysfunction in pathogenesis of asthma. , 2018, Allergology international : official journal of the Japanese Society of Allergology.

[61]  A. Wilks,et al.  Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts. , 1995, Blood.

[62]  M. V. van Leeuwen,et al.  Correction of granulocytopenia in Felty's syndrome by granulocyte-macrophage colony-stimulating factor. Simultaneous induction of interleukin-6 release and flare-up of the arthritis. , 1989, Blood.