Autonomously vascularized cellular constructs in tissue engineering: opening a new perspective for biomedical science

•  Introduction •  Cellular homeostasis and vascularization •  Importance of vascularization: historical review •  Multicellular implants in vivo •  Models of axial vascular induction •  Development of the AV loop model •  Angiogenesis in multicellular implants in vivo: authors' experience –  Surgical technique –  Chamber –  Soft matrices –  Modulation –  Solid matrices –  Cell seeding –  Evaluation methods •  Physiology of angiogenesis in the AV loop –  Flow dynamics and morphology –  Molecular biology of angiogenesis in the loop •  Axially vascularized constructs as tools for research –  Application in basic biomedical science Recombinant cell populations Modulation of angiogenesis Hematogenous metastasis of tumours Recombinant cell populations Modulation of angiogenesis Hematogenous metastasis of tumours Hematogenous metastasis of tumours –  Applications in reparative medicine Multicellular implants Vascular grafts and bio‐artificial vessels Multicellular implants Vascular grafts and bio‐artificial vessels •  Conclusion

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