Dynamical Breaking of Supersymmetry

General conditions for dynamical supersymmetry breaking are discussed. Very small effects that would usually be ignored, such as instantons of a grand unified theory, might break supersymmetry at a low energy scale. Examples are given (in 0 + 1 and 2 + 1 dimensions) in which dynamical supersymmetry breaking occurs. Difficulties that confront such a program in four dimensions are described.