Sensitivity enhanced nanothermal sensors for photoacoustic temperature mapping

Photoacoustic imaging can be used to guide and validate the therapeutic outcome of nanoparticle‐mediated photothermal therapy through its ability to visualize the delivery of nanoparticle contrast agents, image the temperature distribution inside living tissue, and confirm tissue coagulation. In this image‐guided process, temperature mapping plays a critical role for thermal dosage control. Therefore, developing a sensitive and accurate photoacoustic technique to quantitatively measure the temperature distribution during thermal therapy is essential. In this study, we investigated and demonstrated that silica‐coated gold nanorods, can provide a multi‐fold improvement in sensitivity of the photoacoustic temperature mapping compared to gold nanorods without silica coating, and serve as a nanothermal sensor to accurately and quantitatively visualize temperature distributions during photothermal therapy. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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