Pulmonary aspergilloma—clinical immunology

Twenty‐eight selected patients with pulmonary aspergilloma and many with respiratory symptoms were investigated. Their atopic status was evaluated and immunological reactivity to extracts of A. fumigatus studied by means of skin, serological and inhalation challenge tests. The findings suggested that immunological mechanisms may have played a role in producing symptoms in 75% of these patients. Based on these findings, corticosteroids may have a place in treatment of some patients with pulmonary aspergilloma. Care in the use of corticosteroids is recommended because of the prevalence of bacterial infection. Suggestions are offered for selecting patients likely to respond to corticosteroid drugs.

[1]  H. Koester,et al.  [Bronchopulmonary aspergillosis]. , 1975, Dermatologische Monatschrift.

[2]  J. Pepys,et al.  Cryptogenic pulmonary eosinophilias , 1973, Clinical allergy.

[3]  A. R. Somner,et al.  Pulmonary aspergillomas treated with corticosteroids , 1972, Thorax.

[4]  J. Pepys,et al.  Allergic broncho‐pulmonary aspergillosis Clinical immunology: (2) Skin, nasal and bronchial tests , 1971, Clinical allergy.

[5]  J. Pepys,et al.  Allergic broncho‐pulmonary aspergillosis , 1971 .

[6]  C. Hilvering,et al.  Inhalation experiments with extracts of Aspergillus fumigatus on patients with allergic aspergillosis and aspergilloma , 1970, Thorax.

[7]  C. Hilvering,et al.  Fever in aspergillus mycetoma , 1970, Thorax.

[8]  Aspergilloma and residual tuberculous cavities--the results of a resurvey. , 1970, Tubercle.

[9]  F. Hargreave,et al.  The radiological appearances in allergic broncho-pulmonary aspergillosis. , 1970, Clinical radiology.

[10]  McCarthy Ds.  Bronchiectasis in allergic bronchopulmonary aspergillosis. , 1968 .

[11]  J. Scadding,et al.  Bronchiectasis in Allergic Bronchopulmonary Aspergillosis , 1968, Proceedings of the Royal Society of Medicine.

[12]  M. Burns.  Precipitins to pneumococcal C-substance polysaccharide in the serum of patients with chronic bronchial disorders. , 1968, Lancet.

[13]  D. Rifkind,et al.  Systemic fungal infections complicating renal transplantation and immunosuppressive therapy. Clinical, microbiologic, neurologic and pathologic features. , 1968, The American journal of medicine.

[14]  D. Rifkind,et al.  Systemic fungal infections complicating renal transplantation and immunosuppressive therapy: Clinical, microbiologic, neurologic and pathologic features , 1967 .

[15]  M. Burns,et al.  Haemophilus influenzae precipitins in the serum of patients with chronic bronchial disorders. , 1967, Lancet.

[16]  J. G. Scaddino.  The bronchi in allergic aspergillosis. , 1967 .

[17]  J. Longbottom,et al.  DIAGNOSTIC PRECIPITIN TEST IN ASPERGILLUS PULMONARY MYCETOMA. , 1964, Lancet.

[18]  Y. Clayton,et al.  FUNGI IN THE AIR OF HOSPITAL WARDS. , 1963, Journal of general microbiology.

[19]  J. V. Williams,et al.  Inhalation and Skin Tests with Extracts of Hay and Fungi in Patients with Farmer's Lung , 1963, Thorax.

[20]  F. Prime,et al.  An Assessment of the Steady-state Carbon Monoxide Method of Estimating Pulmonary Diffusing Capacity , 1959, Thorax.

[21]  L. Friedman,et al.  The effect of cortisone and antibiotic agents on experimental pulmonary aspergillosis. , 1959, The American journal of pathology.

[22]  R. Torack.  Fungus infections associated with antibiotic and steroid therapy. , 1957, The American journal of medicine.

[23]  D. Bates,et al.  The pulmonary diffusing capacity in normal subjects , 1955, The Journal of physiology.