The contingent negative variation (CNV): timing isn’t everything

When participants time intervals ranging from several hundred milliseconds to several seconds a negative polarity waveform, known as the contingent negative variation (CNV), manifests in the ongoing electroencephalogram (EEG). The perceptual and cognitive functions underlying this component are subject to ongoing debate. Moreover, recent evidence suggests that the link between the CNV and behavioral performance is non-linear and changes depending on the cognitive context. We suggest that the CNV reflects a common core preparatory process related to brain system optimization, and other cognitive processes that depend on the specific timing task employed.

[1]  Warren H. Meck,et al.  Bayesian optimization of time perception , 2013, Trends in Cognitive Sciences.

[2]  J. Obleser,et al.  Alpha Oscillatory Dynamics Index Temporal Expectation Benefits in Working Memory. , 2015, Cerebral cortex.

[3]  Hedderik van Rijn,et al.  Decoupling Interval Timing and Climbing Neural Activity: A Dissociation between CNV and N1P2 Amplitudes , 2014, The Journal of Neuroscience.

[4]  A. Nobre,et al.  Dissociating explicit timing from temporal expectation with fMRI , 2008, Current Opinion in Neurobiology.

[5]  Juliana Yordanova,et al.  Simultaneous EEG and fMRI Reveals a Causally Connected Subcortical-Cortical Network during Reward Anticipation , 2013, The Journal of Neuroscience.

[6]  Catalin V. Buhusi,et al.  What makes us tick? Functional and neural mechanisms of interval timing , 2005, Nature Reviews Neuroscience.

[7]  Birte U. Forstmann,et al.  Trial-by-trial fluctuations in CNV amplitude reflect anticipatory adjustment of response caution , 2014, NeuroImage.

[8]  Hedderik van Rijn,et al.  Tonic and phasic dopamine fluctuations as reflected in beta-power predict interval timing behavior , 2014 .

[9]  Tadeusz W. Kononowicz,et al.  Slow Potentials in Time Estimation: The Role of Temporal Accumulation and Habituation , 2011, Front. Integr. Neurosci..

[10]  W. Maass,et al.  State-dependent computations: spatiotemporal processing in cortical networks , 2009, Nature Reviews Neuroscience.

[11]  E M Glaser,et al.  Event related potentials and time estimation. , 1977, Psychophysiology.

[12]  Warren H. Meck,et al.  Contingent negative variation and its relation to time estimation: a theoretical evaluation , 2011, Front. Integr. Neurosci..

[13]  Martin Wiener,et al.  Parietal Influence on Temporal Encoding Indexed by Simultaneous Transcranial Magnetic Stimulation and Electroencephalography , 2012, The Journal of Neuroscience.

[14]  Virginie van Wassenhove,et al.  Duration estimation entails predicting when , 2015, NeuroImage.

[15]  Laurent Hugueville,et al.  Neural network involved in time perception: An fMRI study comparing long and short interval estimation , 2005, Human brain mapping.

[16]  M. Treisman Temporal discrimination and the indifference interval. Implications for a model of the "internal clock". , 1963, Psychological monographs.

[17]  H. Kornhuber,et al.  Distribution of readiness potential, pre-motion positivity, and motor potential of the human cerebral cortex preceding voluntary finger movements , 2004, Experimental Brain Research.

[18]  Hugo Merchant,et al.  Information Processing in the Primate Basal Ganglia during Sensory-Guided and Internally Driven Rhythmic Tapping , 2014, The Journal of Neuroscience.

[19]  Byron M. Yu,et al.  Neural Variability in Premotor Cortex Provides a Signature of Motor Preparation , 2006, The Journal of Neuroscience.

[20]  Franck Vidal,et al.  The supplementary motor area in motor and sensory timing: evidence from slow brain potential changes , 1999, Experimental Brain Research.

[21]  Hugo Merchant,et al.  Neurophysiology of timing in the hundreds of milliseconds: multiple layers of neuronal clocks in the medial premotor areas. , 2014, Advances in experimental medicine and biology.

[22]  Franck Vidal,et al.  When to act, or not to act: that's the SMA's question , 2016, Current Opinion in Behavioral Sciences.

[23]  M. Wittmann The inner sense of time: how the brain creates a representation of duration , 2013, Nature Reviews Neuroscience.

[24]  T Elbert,et al.  The processing of temporal intervals reflected by CNV-like brain potentials. , 1991, Psychophysiology.

[25]  Richard Ragot,et al.  Relationship between CNV and timing of an upcoming event , 2005, Neuroscience Letters.

[26]  Hugo Merchant,et al.  Measuring time with different neural chronometers during a synchronization-continuation task , 2011, Proceedings of the National Academy of Sciences.

[27]  Emotional modulation of attention affects time perception: evidence from event-related potentials. , 2014, Acta psychologica.

[28]  A. Ferrandez,et al.  ERPs and PET analysis of time perception: Spatial and temporal brain mapping during visual discrimination tasks , 2000, Human brain mapping.

[29]  Martin Wiener,et al.  Repetition enhancement and memory effects for duration , 2015, NeuroImage.

[30]  F. Macar,et al.  Contingent negative variation in processes of expectancy, motor preparation and time estimation , 1985, Biological Psychology.

[31]  R M Church,et al.  Scalar Timing in Memory , 1984, Annals of the New York Academy of Sciences.

[32]  Geoffrey M. Ghose,et al.  Temporal Production Signals in Parietal Cortex , 2012, PLoS biology.

[33]  Tadeusz W. Kononowicz,et al.  In Search of Oscillatory Traces of the Internal Clock , 2016, Front. Psychol..

[34]  Stefan Debener,et al.  Size matters: effects of stimulus size, duration and eccentricity on the visual gamma-band response , 2004, Clinical Neurophysiology.

[35]  S. Tobimatsu,et al.  Perceptual inequality between two neighboring time intervals defined by sound markers: correspondence between neurophysiological and psychological data , 2014, Front. Psychol..

[36]  Biyu J He,et al.  Spatiotemporal Dissociation of Brain Activity Underlying Subjective Awareness, Objective Performance and Confidence , 2014, The Journal of Neuroscience.

[37]  Joachim Haß,et al.  The Neural Representation of Time: An Information-Theoretic Perspective , 2012, Neural Computation.

[38]  D. Mcadam Slow potential changes recorded from human brain during learning of a temporal interval , 1966 .

[39]  D. Buonomano,et al.  Population clocks: motor timing with neural dynamics , 2010, Trends in Cognitive Sciences.

[40]  T. Kononowicz Dopamine-dependent oscillations in frontal cortex index “start-gun” signal in interval timing , 2015, Front. Hum. Neurosci..

[41]  Warren H. Meck,et al.  Oscillatory multiplexing of neural population codes for interval timing and working memory , 2015, Neuroscience & Biobehavioral Reviews.

[42]  Catherine Tallon-Baudry,et al.  Time is more than a sensory feature: Attending to duration triggers specific anticipatory activity , 2011, Cognitive neuroscience.

[43]  Niko A. Busch,et al.  Flicker-Induced Time Dilation Does Not Modulate EEG Correlates of Temporal Encoding , 2014, Brain Topography.

[44]  N. Narayanan,et al.  D1-Dependent 4 Hz Oscillations and Ramping Activity in Rodent Medial Frontal Cortex during Interval Timing , 2014, The Journal of Neuroscience.

[45]  Jozsef Csicsvari,et al.  Disrupted Dopamine Transmission and the Emergence of Exaggerated Beta Oscillations in Subthalamic Nucleus and Cerebral Cortex , 2008, The Journal of Neuroscience.

[46]  Bon-Mi Gu,et al.  Dedicated clock/timing-circuit theories of time perception and timed performance. , 2014, Advances in experimental medicine and biology.

[47]  A. Nobre,et al.  Endogenous modulation of low frequency oscillations by temporal expectations , 2011, Journal of neurophysiology.

[48]  Scott D. Brown,et al.  Neural Correlates of Trial-to-Trial Fluctuations in Response Caution , 2011, The Journal of Neuroscience.

[49]  I. Tarkka,et al.  Electric source localization adds evidence for task-specific CNVs. , 1998, Behavioural neurology.

[50]  T. Penney,et al.  Probing interval timing with scalp-recorded electroencephalography (EEG). , 2014, Advances in experimental medicine and biology.

[51]  B. Ross,et al.  Internalized Timing of Isochronous Sounds Is Represented in Neuromagnetic Beta Oscillations , 2012, The Journal of Neuroscience.

[52]  S. Grondin,et al.  EEG Investigations of Duration Discrimination: The Intermodal Effect Is Induced by an Attentional Bias , 2013, PloS one.

[53]  Hedderik van Rijn,et al.  Single trial beta oscillations index time estimation , 2015, Neuropsychologia.

[54]  H. Rijn,et al.  Neuroelectromagnetic signatures of the reproduction of supra-second durations , 2015, Neuropsychologia.

[55]  Yuejia Luo,et al.  The Attention Modulation on Timing: An Event-Related Potential Study , 2013, PloS one.

[56]  Kwun Kei Ng,et al.  Temporal Accumulation and Decision Processes in the Duration Bisection Task Revealed by Contingent Negative Variation , 2011, Front. Integr. Neurosci..

[57]  C. Brunia,et al.  Distribution of slow brain potentials related to motor preparation and stimulus anticipation in a time estimation task. , 1988, Electroencephalography and clinical neurophysiology.

[58]  Ina M. Tarkka,et al.  Task-Specific Expectation Is Revealed in Scalp-Recorded Slow Potentials , 2004, Brain Topography.

[59]  W. Walter,et al.  Contingent Negative Variation : An Electric Sign of Sensori-Motor Association and Expectancy in the Human Brain , 1964, Nature.

[60]  Wim J. Riedel,et al.  Contingent negative variation as a dopaminergic biomarker: evidence from dose-related effects of methylphenidate , 2011, Psychopharmacology.

[61]  Franck Vidal,et al.  The CNV peak: an index of decision making and temporal memory. , 2003, Psychophysiology.

[62]  Masaki Tanaka,et al.  Cognitive Signals in the Primate Motor Thalamus Predict Saccade Timing , 2007, The Journal of Neuroscience.

[63]  Biyu J. He,et al.  Average Is Optimal: An Inverted-U Relationship between Trial-to-Trial Brain Activity and Behavioral Performance , 2013, PLoS Comput. Biol..

[64]  Giovanni Mento,et al.  The passive CNV: carving out the contribution of task-related processes to expectancy , 2013, Front. Hum. Neurosci..

[65]  Ann-Christine Ehlis,et al.  The time course of temporal discrimination: An ERP study , 2010, Clinical Neurophysiology.

[66]  Srikantan S Nagarajan,et al.  Auditory Cortical Plasticity in Learning to Discriminate Modulation Rate , 2007, The Journal of Neuroscience.

[67]  Christopher J. Cueva,et al.  Natural Grouping of Neural Responses Reveals Spatially Segregated Clusters in Prearcuate Cortex , 2015, Neuron.

[68]  John Anderson,et al.  An integrated theory of prospective time interval estimation: the role of cognition, attention, and learning. , 2007, Psychological review.

[69]  Dean V. Buonomano,et al.  Timing as an intrinsic property of neural networks: evidence from in vivo and in vitro experiments , 2014, Philosophical Transactions of the Royal Society B: Biological Sciences.

[70]  Melissa J. Allman,et al.  Pathophysiological distortions in time perception and timed performance. , 2012, Brain : a journal of neurology.

[71]  A W Gaillard,et al.  The late CNV wave: preparation versus expectancy. , 1977, Psychophysiology.

[72]  W. Meck,et al.  Cortico-striatal circuits and interval timing: coincidence detection of oscillatory processes. , 2004, Brain research. Cognitive brain research.

[73]  Tatiana Foroud,et al.  Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[74]  B. Rockstroh,et al.  Slow potentials of the cerebral cortex and behavior. , 1990, Physiological reviews.

[75]  S. Bickel,et al.  Expectancy-related modulations of neural oscillations in continuous performance tasks , 2012, NeuroImage.

[76]  J. Tecce Contingent negative variation (CNV) and psychological processes in man. , 1972, Psychological bulletin.

[77]  Michela Sarlo,et al.  Automatic Temporal Expectancy: A High-Density Event-Related Potential Study , 2013, PloS one.

[78]  Hugo Merchant,et al.  Neural basis of the perception and estimation of time. , 2013, Annual review of neuroscience.

[79]  An early resolution of contingent negative variation (CNV) in the discrimination. , 1982, Electroencephalography and clinical neurophysiology.

[80]  O. Jensen,et al.  Asymmetric Amplitude Modulations of Brain Oscillations Generate Slow Evoked Responses , 2008, The Journal of Neuroscience.