Easier threading through web-based comparisons and cross-validations

UNLABELLED We have developed a WWW server for the integration and comparison of protein structure predictions performed by five different servers. Users submit an amino acid sequence to a selected set of these prediction methods. Results are gathered on a web-based page in order to facilitate comparison and analysis. All the alignments are further evaluated through a common threading tool making their comparisons easier. AVAILABILITY The meta-server is available free at http://www.infobiosud.cnrs.fr/bioserver SUPPLEMENTARY INFORMATION http://www.infobiosud.cnrs.fr/bioserver/hah1.html

[1]  S. Bryant,et al.  An empirical energy function for threading protein sequence through the folding motif , 1993, Proteins.

[2]  B Rost,et al.  Bridging the protein sequence-structure gap by structure predictions. , 1996, Annual review of biophysics and biomolecular structure.

[3]  John P. Overington,et al.  HOMSTRAD: A database of protein structure alignments for homologous families , 1998, Protein science : a publication of the Protein Society.

[4]  Geoffrey J. Barton,et al.  JPred : a consensus secondary structure prediction server , 1999 .

[5]  F. S. Mathews,et al.  HAH1 Is a Copper-binding Protein with Distinct Amino Acid Residues Mediating Copper Homeostasis and Antioxidant Defense* , 1998, The Journal of Biological Chemistry.

[6]  J. P. Mornon,et al.  Incremental threading optimization (TITO) to help alignment and modelling of remote homologues , 1998, Bioinform..

[7]  Burkhard Rost,et al.  A platform for integrating threading results with protein family analyses , 1999, Bioinform..

[8]  David C. Jones,et al.  GenTHREADER: an efficient and reliable protein fold recognition method for genomic sequences. , 1999, Journal of molecular biology.

[9]  A. Wernimont,et al.  Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins , 2000, Nature Structural Biology.

[10]  M. Sternberg,et al.  Enhanced genome annotation using structural profiles in the program 3D-PSSM. , 2000, Journal of molecular biology.

[11]  D Fischer,et al.  LiveBench‐1: Continuous benchmarking of protein structure prediction servers , 2001, Protein science : a publication of the Protein Society.