RAISIN - a national programme for early warning, investigation and surveillance of healthcare-associated infection in France.

Surveillance is a key component of the French plan for prevention of healthcare-associated infection (HAI) and has progressively evolved in the past decades. We describe the development and current organisation of surveillance of HAI in France and summarise key achievements and results. Surveillance of HAI is under the auspice of the national institute for public health surveillance through a central coordinating structure, the Reseau d alerte, d investigation et de surveillance des infections nosocomiales (RAISIN), which consists of five regional coordinating structures, two national advisory committees of the Ministry of Health and public health agencies. Surveillance includes the performance of national prevalence surveys every five years (latest in 2006), specific surveillance networks to follow trends and characterise HAI that are national priority, and mandatory reporting of HAI that meet specific criteria for alert purposes. RAISIN prioritises activities, defines technical specifications of surveillance systems, coordinates their implementation, and supports response to alerts, emergences or outbreaks of HAI. We demonstrate that the French surveillance program of HAI has become comprehensive and contributes to evaluating the impact of control and prevention of HAI. Data from RAISIN indicate a general decrease in the risk of HAI in acute care in France. They show a decrease in HAI during recent years, particularly of those related to methicillin-resistant Staphylococcus aureus (MRSA) for which a drop of 38% was documented between 2001 and 2006. RAISIN is also integrated into European surveillance of HAI coordinated by the European Centre for Disease Control.

[1]  D. D. Des Jarlais,et al.  Prevalence of hepatitis A among drug users in north-eastern Italy. Is vaccination necessary in low prevalence areas? , 2005, European journal of public health.

[2]  A. Vatopoulos,et al.  Community acquired MRSA infections in a paediatric population in Greece. , 2005, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[3]  Liang Chen,et al.  Epidemic community-associated methicillin-resistant Staphylococcus aureus: Recent clonal expansion and diversification , 2008, Proceedings of the National Academy of Sciences.

[4]  Y. Lerman,et al.  Seroepidemiology of hepatitis A antibodies among children’s hospital staff , 2002, The Pediatric infectious disease journal.

[5]  G. Vitiello,et al.  Vaccination strategies against hepatitis A in southern Europe. , 2003, Vaccine.

[6]  S. Ray,et al.  Emergence of Community-Acquired Methicillin-Resistant Staphylococcus aureus USA 300 Clone as the Predominant Cause of Skin and Soft-Tissue Infections , 2006, Annals of Internal Medicine.

[7]  D. Kafetzis,et al.  Clinical and molecular epidemiology of community-acquired, methicillin-resistant Staphylococcus aureus infections in children in central Greece , 2008, European Journal of Clinical Microbiology & Infectious Diseases.

[8]  D. Oliveira,et al.  Multiplex PCR Strategy for Rapid Identification of Structural Types and Variants of the mec Element in Methicillin-Resistant Staphylococcus aureus , 2002, Antimicrobial Agents and Chemotherapy.

[9]  V. Potapov,et al.  The first isolation of Panton-Valentine leukocidin (PVL) positive community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) in Russia. , 2007, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[10]  A. Zanetti,et al.  Risk groups for hepatitis A virus infection. , 2003, Vaccine.

[11]  J. Gray,et al.  MRSA in children presenting to hospitals in Birmingham, UK. , 2007, The Journal of hospital infection.

[12]  M. Massari,et al.  Epidemiological and virological characterization of a large community-wide outbreak of hepatitis A in southern Italy , 2007, Epidemiology and Infection.

[13]  G. Dimitracopoulos,et al.  Spread of Staphylococcus aureus clinical isolates carrying Panton-Valentine leukocidin genes during a 3-year period in Greece. , 2006, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[14]  A. Hornero,et al.  Community-acquired methicillin-resistant Staphylococcus aureus infections: an emerging threat in Spain. , 2008, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[15]  A. Zanetti,et al.  Hepatitis A, Italy , 2005, Emerging infectious diseases.

[16]  R. Koff Review article: vaccination and viral hepatitis – current status and future prospects , 2007, Alimentary pharmacology & therapeutics.

[17]  F. Vandenesch,et al.  Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. , 1999, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[18]  Lisa M. Lee,et al.  Estimation of HIV incidence in the United States. , 2008, JAMA.

[19]  F. Vandenesch,et al.  Global Distribution of Panton-Valentine Leukocidin–positive Methicillin-resistant Staphylococcus aureus, 2006 , 2007, Emerging infectious diseases.

[20]  J. Weber Community-associated methicillin-resistant Staphylococcus aureus. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[21]  B. Cookson,et al.  Staphylococcus aureus Isolates Carrying Panton-Valentine Leucocidin Genes in England and Wales: Frequency, Characterization, and Association with Clinical Disease , 2005, Journal of Clinical Microbiology.

[22]  Mimmo Iannelli,et al.  Basic mathematical models for the temporal dynamics of HAV in medium-endemicity Italian areas. , 2008, Vaccine.

[23]  H. de Lencastre,et al.  Two International Methicillin-Resistant Staphylococcus aureus Clones Endemic in a University Hospital in Patras, Greece , 2003, Journal of Clinical Microbiology.

[24]  W. Witte,et al.  Methicillin-resistant Staphylococcus aureus containing the Panton-Valentine leucocidin gene in Germany in 2005 and 2006. , 2007, The Journal of antimicrobial chemotherapy.

[25]  H. Mittermayer,et al.  PVL-positive MRSA in Austria , 2007, European Journal of Clinical Microbiology & Infectious Diseases.

[26]  R. Goering,et al.  Epidemiology of European Community-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 80 Type IV Strains Isolated in Denmark from 1993 to 2004 , 2007, Journal of Clinical Microbiology.

[27]  M. Rapicetta,et al.  Baseline seroepidemiology of hepatitis a virus infection among children and teenagers in Italy , 1991, Infection.

[28]  F. Vandenesch,et al.  Community-Acquired Methicillin-Resistant Staphylococcus aureus Carrying Panton-Valentine Leukocidin Genes: Worldwide Emergence , 2003, Emerging infectious diseases.

[29]  A. Kraigher,et al.  Monitoring CA-MRSA infections in Slovenia. , 2005, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[30]  B. Bell,et al.  Hepatitis A virus , 2016 .

[31]  J. Rothgänger,et al.  Typing of Methicillin-Resistant Staphylococcus aureus in a University Hospital Setting by Using Novel Software for spa Repeat Determination and Database Management , 2003, Journal of Clinical Microbiology.

[32]  M. Kaufmann,et al.  Harmonization of Pulsed-Field Gel Electrophoresis Protocols for Epidemiological Typing of Strains of Methicillin-Resistant Staphylococcus aureus: a Single Approach Developed by Consensus in 10 European Laboratories and Its Application for Tracing the Spread of Related Strains , 2003, Journal of Clinical Microbiology.

[33]  S. Salmaso,et al.  Determinants of acquiring hepatitis A virus disease in a large Italian region in endemic and epidemic periods , 2005, Journal of viral hepatitis.

[34]  P. Vanhems,et al.  Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients , 2002, The Lancet.

[35]  E. Sagnelli,et al.  Exposure to HAV infection in patients with chronic liver disease in Italy, a multicentre study * , 2006, Journal of viral hepatitis.

[36]  B. Salzberger,et al.  Healthcare-associated outbreaks and community-acquired infections due to MRSA carrying the Panton-Valentine leucocidin gene in southeastern Germany , 2005, European Journal of Clinical Microbiology and Infectious Diseases.

[37]  P. Nordmann,et al.  Three-year survey of community-acquired methicillin-resistant Staphylococcus aureus producing Panton-Valentine leukocidin in a French university hospital. , 2005, The Journal of hospital infection.

[38]  S. Kapoor,et al.  The changing epidemiological pattern of hepatitis A in an urban population of India: Emergence of a trend similar to the European countries , 2000, European Journal of Epidemiology.

[39]  H. Maltezou,et al.  Community-acquired methicillin-resistant Staphylococcus aureus infections. , 2006, International journal of antimicrobial agents.

[40]  A. Plasència,et al.  Declining hepatitis A seroprevalence in adults in Catalonia (Spain): a population-based study , 2007, BMC infectious diseases.

[41]  R. Prato,et al.  Control of Hepatitis A by Universal Vaccination of Adolescents, Puglia, Italy , 2008, Emerging infectious diseases.

[42]  Bianca Bruzzone,et al.  Hepatitis A incidence and hospital-based seroprevalence in Italy: a nation-wide study , 2007, European Journal of Epidemiology.

[43]  It Istituto Superiore di Sanit,et al.  Epidemiology of acute viral hepatitis: twenty years of surveillance through SEIEVA in Italy and a review of the literature , 2006 .

[44]  A. Gervaix,et al.  Community-acquired methicillin-resistant Staphylococcus aureus in Switzerland : first surveillance report. , 2006, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.