Differential Expression and Distinct Roles of Proteinase-Activated Receptor 2 in Microglia and Neurons in Neonatal Mouse Brain After Hypoxia-Ischemic Injury

[1]  H. Nakanishi,et al.  Cathepsin H deficiency decreases hypoxia-ischemia-induced hippocampal atrophy in neonatal mice through attenuated TLR3/IFN-β signaling , 2021, Journal of Neuroinflammation.

[2]  H. Qing,et al.  Nucleus distribution of cathepsin B in senescent microglia promotes brain aging through degradation of sirtuins , 2020, Neurobiology of Aging.

[3]  Zhong-Ping Feng,et al.  Animal models for neonatal brain injury induced by hypoxic ischemic conditions in rodents , 2020, Experimental Neurology.

[4]  H. Qing,et al.  Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling , 2020, Journal of neurochemistry.

[5]  Resident,et al.  Resident , 2020, The Caravan.

[6]  D. Ragozzino,et al.  Microglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission. , 2019, Seminars in cell & developmental biology.

[7]  L. Giménez-Llort,et al.  Severe Perinatal Hypoxic-Ischemic Brain Injury Induces Long-Term Sensorimotor Deficits, Anxiety-Like Behaviors and Cognitive Impairment in a Sex-, Age- and Task-Selective Manner in C57BL/6 Mice but Can Be Modulated by Neonatal Handling , 2019, Front. Behav. Neurosci..

[8]  N. Seidah,et al.  HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin , 2019, Cell Death & Differentiation.

[9]  H. Nakanishi,et al.  Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice , 2018, Aging cell.

[10]  H. Nakanishi,et al.  The Critical Role of IL-10 in the Antineuroinflammatory and Antioxidative Effects of Rheum tanguticum on Activated Microglia , 2018, Oxidative medicine and cellular longevity.

[11]  H. Nakanishi,et al.  Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice , 2017, Scientific Reports.

[12]  C. Sommer.  Ischemic stroke: experimental models and reality , 2017, Acta Neuropathologica.

[13]  R. Plevin,et al.  Protease-Activated Receptor 2: Are Common Functions in Glial and Immune Cells Linked to Inflammation-Related CNS Disorders? , 2016, Current drug targets.

[14]  H. Nakanishi,et al.  The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage , 2015, The Journal of Neuroscience.

[15]  K. Blomgren,et al.  Resident microglia, rather than blood‐derived macrophages, contribute to the earlier and more pronounced inflammatory reaction in the immature compared with the adult hippocampus after hypoxia‐ischemia , 2015, Glia.

[16]  H. Nakanishi,et al.  Peripheral Role of Cathepsin S in Th1 Cell-Dependent Transition of Nerve Injury-Induced Acute Pain to a Chronic Pain State , 2014, The Journal of Neuroscience.

[17]  Max Gassmann,et al.  Involvement of oxidative stress in hypoxia-induced blood-brain barrier breakdown. , 2012, Microvascular research.

[18]  M. Johansson,et al.  Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2–mediated heparin-binding EGF signaling in endothelial cells , 2011, Proceedings of the National Academy of Sciences.

[19]  A. Tolkovsky,et al.  Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death , 2011, The Journal of Immunology.

[20]  N. Mackman,et al.  Protease-Activated Receptor 2 Deficiency Reduces Cardiac Ischemia/Reperfusion Injury , 2010, Arteriosclerosis, thrombosis, and vascular biology.

[21]  T. Tamaya,et al.  Role of protease activated receptor-2 in lymph node metastasis of uterine cervical cancers , 2008, BMC Cancer.

[22]  Keiji Tanaka,et al.  Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. , 2008, The American journal of pathology.

[23]  H. Neumann,et al.  Neuronal ‘On’ and ‘Off’ signals control microglia , 2007, Trends in Neurosciences.

[24]  T. Tamaya,et al.  Role of protease activated receptor-2 in tumor advancement of ovarian cancers. , 2007, Annals of oncology : official journal of the European Society for Medical Oncology.

[25]  M. Hollenberg,et al.  Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis , 2006, The Journal of experimental medicine.

[26]  Takeshi Hayashi,et al.  Deficiency of PAR-2 Gene Increases Acute Focal Ischemic Brain Injury , 2005, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[27]  N. Rooijen,et al.  Microglia Promote the Death of Developing Purkinje Cells , 2004, Neuron.

[28]  M. Ghazizadeh,et al.  Protease‐activated receptor (PAR)‐1 and PAR‐2 participate in the cell growth of alveolar capillary endothelium in primary lung adenocarcinomas , 2003, Cancer.

[29]  K. Dabbagh,et al.  Protease-Activated Receptor 2 Mediates Eosinophil Infiltration and Hyperreactivity in Allergic Inflammation of the Airway1 , 2002, The Journal of Immunology.

[30]  D. Ferriero,et al.  Delayed cell death in neonatal mouse hippocampus from hypoxia-ischemia is neither apoptotic nor necrotic , 2001, Neuroscience Letters.

[31]  R. Vannucci,et al.  A model of Perinatal Hypoxic‐Ischemic Brain Damage a , 1997, Annals of the New York Academy of Sciences.

[32]  C. Turck,et al.  Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface , 1994, Nature.

[33]  V. Wheaton,et al.  Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation , 1991, Cell.

[34]  J. Rice,et al.  The influence of immaturity on hypoxic‐ischemic brain damage in the rat , 1981, Annals of neurology.

[35]  M. Hollenberg,et al.  during HIV Infection Death Neuroinflammation Prevents Neuronal Proteinase-Activated Receptor-2 Induction by , 2013 .

[36]  R. Hohlfeld,et al.  Neuro-immune crosstalk in CNS diseases. , 2010, Results and problems in cell differentiation.

[37]  G. D. Hunter,et al.  Essential role for proteinase-activated receptor-2 in arthritis. , 2003, The Journal of clinical investigation.