Content based image retrieval (CBIR) has become an important factor in medical imaging research and is obtaining a great success. More applications still need to be developed to get more powerful systems for better image similarity matching, and as a result getting better image retrieval systems. This research focuses on implementing low-level descriptors to maximize the quality of the retrieval of medical images. Such a research is supposed to set a better result in terms of image similarity matching. In this research a system that uses low-level descriptors is introduced. Three descriptors have been developed and applied in an attempt to increase the accuracy of image matching. The final results showed a qualified system in medical images retrieval specially that the low-level image descriptors have not been used yet in the image similarity matching in the medical field.