Unusual bone localization of sarcoidosis mimicking metastatic lesions: case report and review of literature

Sarcoidosis is a multisystem disease of unknown origin. Diagnosis remains challenging, based on organ site involvement, histological confirmation of non-caseating granuloma and an appropriate clinical syndrome. Granulomatous bone involvement is rare and may be ignored because it is usually asymptomatic. Vertebrae, ribs and skull localizations are rarely reported. We described an interesting case of a woman with chronic and multiorgan sarcoidosis with unusual bone localizations.

[1]  J. Bernaudin,et al.  How to Tackle the Diagnosis and Treatment in the Diverse Scenarios of Extrapulmonary Sarcoidosis , 2021, Advances in Therapy.

[2]  Alexander G. Mathioudakis,et al.  ERS clinical practice guidelines on treatment of sarcoidosis , 2021, European Respiratory Journal.

[3]  S. Birring,et al.  A review of the musculoskeletal manifestations of sarcoidosis , 2018, Rheumatology.

[4]  R. Baughman,et al.  Clinical characteristics of patients with bone sarcoidosis. , 2017, Seminars in arthritis and rheumatism.

[5]  É. Turcotte,et al.  The great mimicker: an extensive bone sarcoidosis , 2015, European Journal of Nuclear Medicine and Molecular Imaging.

[6]  J. Malghem,et al.  Vertebral sarcoidosis: long-term follow-up with MRI , 2014, Skeletal Radiology.

[7]  A. Anastasilakis,et al.  Central skeletal sarcoidosis: a case report with sustained remission only on methotrexate, and a literature review on the imaging approach, treatment, and assessment of disease activity , 2013, Modern rheumatology.

[8]  J. Laredo,et al.  [Vertebral sarcoidosis. Spontaneous favorable outcome: A case report and literature review]. , 2013, La Revue de medecine interne.

[9]  J. Babb,et al.  Can sarcoidosis and metastatic bone lesions be reliably differentiated on routine MRI? , 2012, AJR. American journal of roentgenology.

[10]  O. Hilberg,et al.  An unusual presentation of sarcoidosis with tetraplegia and severe osteolytic bone lesions , 2011, European Respiratory Journal.

[11]  E. Bargagli,et al.  Rare localizations of bone sarcoidosis: two case reports and review of the literature , 2011, Rheumatology International.

[12]  M. P. Valencia,et al.  Sarcoidosis of the thoracic and lumbar vertebrae, mimicking metastasis or multifocal osteomyelitis by MRI: case report. , 2009, Clinical imaging.

[13]  B. Maldague,et al.  [Principles of analysis for sacroiliac joints imaging]. , 2007, JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie.

[14]  C. Golimbu,et al.  MRI of sarcoidosis patients with musculoskeletal symptoms. , 2005, AJR. American journal of roentgenology.

[15]  E. Neville,et al.  BONE SARCOIDOSIS * , 1976, Annals of the New York Academy of Sciences.