Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways

[1]  N. Zisapel,et al.  Prolonged‐release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects , 2007, Journal of sleep research.

[2]  N. Zisapel,et al.  Nap and melatonin‐induced changes in hippocampal activation and their role in verbal memory consolidation , 2007, Journal of pineal research.

[3]  L. Brusco,et al.  Possible therapeutic value of melatonin in mild cognitive impairment: a retrospective study , 2007, Journal of pineal research.

[4]  D. Cardinali,et al.  Prevention by melatonin of hepatocarcinogenesis in rats injected with N‐nitrosodiethylamine , 2007, Journal of pineal research.

[5]  N. Zisapel,et al.  Efficacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next-day alertness outcomes , 2007, Current medical research and opinion.

[6]  D. Swaab,et al.  Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer's disease. , 2007, Sleep medicine.

[7]  N. Zisapel,et al.  Melatonin and the human hippocampus, a time dependant interplay , 2007, Journal of pineal research.

[8]  D. Swaab,et al.  Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease , 2007, Neurobiology of Aging.

[9]  H. Piggins,et al.  Electrophysiology of the suprachiasmatic circadian clock , 2007, Progress in Neurobiology.

[10]  W. Strober,et al.  Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β , 2007, The Journal of Immunology.

[11]  D. Cardinali,et al.  Melatonin in the eye: implications for glaucoma. , 2007, Experimental eye research.

[12]  J. Stehle,et al.  The mammalian pineal gland: known facts, unknown facets , 2007, Trends in Endocrinology & Metabolism.

[13]  D. Cardinali,et al.  Drug Insight: the use of melatonergic agonists for the treatment of insomnia—focus on ramelteon , 2007, Nature Clinical Practice Neurology.

[14]  N. Zisapel,et al.  Sleep and sleep disturbances: biological basis and clinical implications , 2007, Cellular and Molecular Life Sciences.

[15]  R. Reiter,et al.  Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions. , 2007, Acta biochimica Polonica.

[16]  R. Jockers,et al.  The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease. , 2007, Current Alzheimer research.

[17]  R. Reiter,et al.  One molecule, many derivatives: A never‐ending interaction of melatonin with reactive oxygen and nitrogen species? , 2007, Journal of pineal research.

[18]  D. Blask,et al.  Putting cancer to sleep at night , 2005, Endocrine.

[19]  M. Dubocovich,et al.  Functional MT1 and MT2 melatonin receptors in mammals , 2005, Endocrine.

[20]  D. Tobin,et al.  On the role of melatonin in skin physiology and pathology , 2005, Endocrine.

[21]  D. Cardinali,et al.  Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure , 2003, Endocrine.

[22]  N. Zisapel,et al.  Gi and RGS proteins provide biochemical control of androgen receptor nuclear exclusion , 2007, Journal of Molecular Neuroscience.

[23]  E. Feuer,et al.  Projecting the number of patients with colorectal carcinoma by phases of care in the US: 2000–2020 , 2006, Cancer Causes & Control.

[24]  V. Srinivasan,et al.  Could agomelatine be the ideal antidepressant? , 2006, Expert review of neurotherapeutics.

[25]  D. Cardinali,et al.  Role of melatonin in the eye and ocular dysfunctions , 2006, Visual Neuroscience.

[26]  R. Jockers,et al.  Modulation of melatonin receptors and G‐protein function by microtubules , 2006, Journal of pineal research.

[27]  Y. Sharabi,et al.  Melatonin reduces night blood pressure in patients with nocturnal hypertension. , 2006, The American journal of medicine.

[28]  R. Ravid,et al.  Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer's disease. , 2006, European journal of histochemistry : EJH.

[29]  J. Pácha,et al.  Heterogeneous expression of melatonin receptor MT1 mRNA in the rat intestine under control and fasting conditions , 2006, Journal of pineal research.

[30]  Philippe Delagrange,et al.  The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization , 2006, The EMBO journal.

[31]  D. Cardinali,et al.  Melatonin: Nature's most versatile biological signal? , 2006, The FEBS journal.

[32]  M. Dubocovich.  Agomelatine targets a range of major depressive disorder symptoms. , 2006, Current opinion in investigational drugs.

[33]  N. Zisapel,et al.  Role of protein kinase Cα in melatonin signal transduction , 2006, Molecular and Cellular Endocrinology.

[34]  T. Roth,et al.  Effects of ramelteon on patient-reported sleep latency in older adults with chronic insomnia. , 2006, Sleep medicine.

[35]  Yaniv Assaf,et al.  Sleep-anticipating effects of melatonin in the human brain , 2006, NeuroImage.

[36]  V. Srinivasan,et al.  Melatonin in Alzheimer's disease and other neurodegenerative disorders , 2006, Behavioral and Brain Functions.

[37]  R. Reiter,et al.  The modulatory role of melatonin on immune responsiveness. , 2006, Current opinion in investigational drugs.

[38]  S. V. Anisimov,et al.  Melatonin as antioxidant, geroprotector and anticarcinogen. , 2006, Biochimica et biophysica acta.

[39]  D. Cardinali,et al.  The role of melatonin in immuno‐enhancement: potential application in cancer , 2006, International journal of experimental pathology.

[40]  M. Dowsett,et al.  Urinary 6‐sulfatoxymelatonin levels and their correlations with lifestyle factors and steroid hormone levels , 2006, Journal of pineal research.

[41]  N. Zisapel,et al.  Differential effects of melatonin and its downstream effector PKCα on subcellular localization of RGS proteins , 2006, Journal of pineal research.

[42]  R. Nelson,et al.  Melatonin receptor (MT1) knockout mice display depression-like behaviors and deficits in sensorimotor gating , 2006, Brain Research Bulletin.

[43]  Jiahuai Han,et al.  Nod1-dependent control of tumor growth. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[44]  J. Larson,et al.  Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice , 2006, Neuroscience Letters.

[45]  G. Lincoln.  Melatonin Entrainment of Circannual Rhythms , 2006, Chronobiology international.

[46]  Angela Jackman,et al.  Circadian Uses of Melatonin in Humans , 2006, Chronobiology international.

[47]  G. Benítez-King.  Melatonin as a cytoskeletal modulator: implications for cell physiology and disease , 2006, Journal of pineal research.

[48]  D. Cardinali,et al.  Melatonin in mood disorders , 2006, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[49]  J. Boutin,et al.  Therapeutic Potential of Melatonin Ligands , 2006, Chronobiology international.

[50]  Josephine Arendt,et al.  Melatonin and Human Rhythms , 2006, Chronobiology international.

[51]  A. Ortega,et al.  Effect of melatonin on β-tubulin and MAP2 expression in NIE-115 cells , 1996, Neurochemical Research.

[52]  D. Cardinali,et al.  Melatonin in Circadian Rhythm Sleep Disorders , 2006 .

[53]  H. Manev,et al.  Drug- and region-specific effects of protracted antidepressant and cocaine treatment on the content of melatonin MT(1) and MT(2) receptor mRNA in the mouse brain. , 2006, International journal of neuroprotection and neuroregeneration.

[54]  C. Guilleminault,et al.  Agomelatine , 2006, CNS drugs.

[55]  J. Rada,et al.  Melatonin receptors in chick ocular tissues: implications for a role of melatonin in ocular growth regulation. , 2006, Investigative ophthalmology & visual science.

[56]  H. Bartsch,et al.  The Anti-tumor Activity of Pineal Melatonin and Cancer Enhancing Life Styles in Industrialized Societies , 2006, Cancer Causes & Control.

[57]  D. Cardinali,et al.  The Use of Chronobiotics in the Resynchronization of the Sleep–wake Cycle , 2006, Cancer Causes & Control.

[58]  R. Stevens.  Environmental Health Sciences , 2021 .

[59]  D. Cardinali,et al.  Melatonin and sleep in aging population , 2005, Experimental Gerontology.

[60]  H. Korf,et al.  Mechanisms Regulating Melatonin Synthesis in the Mammalian Pineal Organ , 2005, Annals of the New York Academy of Sciences.

[61]  M. Dubocovich,et al.  Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats. , 2005, Cancer research.

[62]  V. Srinivasan,et al.  Melatonin, immune function and aging , 2005, Immunity & Ageing.

[63]  C. Colwell,et al.  Melatonin inhibits hippocampal long‐term potentiation , 2005, The European journal of neuroscience.

[64]  M. Millan,et al.  Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. , 2005, Therapie.

[65]  E. van Cauter,et al.  Phase‐shifts of 24‐h rhythms of hormonal release and body temperature following early evening administration of the melatonin agonist agomelatine in healthy older men , 2005, Clinical endocrinology.

[66]  Glenna A Dowling,et al.  Melatonin for sleep disturbances in Parkinson's disease. , 2005, Sleep medicine.

[67]  H. Daniel,et al.  Melatonin potentiates flavone‐induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products , 2005, International journal of cancer.

[68]  G. Ferry,et al.  Molecular tools to study melatonin pathways and actions. , 2005, Trends in pharmacological sciences.

[69]  Derk-Jan Dijk,et al.  Timing and Consolidation of Human Sleep, Wakefulness, and Performance by a Symphony of Oscillators , 2005, Journal of biological rhythms.

[70]  R. Hardeland.  Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance. , 2005, Endocrine.

[71]  F. Kwiatkowski,et al.  Potentiel thérapeutique de la mélatonine dans la prise en charge de la pathologie cancéreuse , 2005 .

[72]  Yogesh K. Dwivedi,et al.  The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system. , 2005, Brain research. Molecular brain research.

[73]  N. Wray,et al.  Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor , 2005, Molecular Psychiatry.

[74]  P. Morgan,et al.  The Human MT1 Melatonin Receptor Stimulates cAMP Production in the Human Neuroblastoma Cell Line SH‐SY5Y Cells Via a Calcium‐Calmodulin Signal Transduction Pathway , 2005, Journal of neuroendocrinology.

[75]  O. Pignataro,et al.  Direct effect of melatonin on Syrian hamster testes: melatonin subtype 1a receptors, inhibition of androgen production, and interaction with the local corticotropin-releasing hormone system. , 2005, Endocrinology.

[76]  T. Roth,et al.  Ramelteon (TAK-375), a selective MT1/MT2-receptor agonist, reduces latency to persistent sleep in a model of transient insomnia related to a novel sleep environment. , 2005, Sleep.

[77]  Josephine Arendt,et al.  Melatonin as a chronobiotic. , 2005, Sleep medicine reviews.

[78]  Bruno Claustrat,et al.  The basic physiology and pathophysiology of melatonin. , 2005, Sleep medicine reviews.

[79]  A. Carrillo-Vico,et al.  0021-972X/05/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 90(2):992–1000 Printed in U.S.A. Copyright © 2005 by The Endocrine Society doi: 10.1210/jc.2004-1429 Human Lymphocyte-Synthesized Melatonin Is Involved in the Regulation of the Inter , 2004 .

[80]  D. Klein,et al.  Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[81]  R. Ravid,et al.  Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease , 2005, Journal of pineal research.

[82]  G. Benítez-King,et al.  Calmodulin mediates melatonin cytoskeletal effects , 1993, Experientia.

[83]  D. Cardinali,et al.  Neuroendocrine Correlates of Sleep/Wakefulness , 2005 .

[84]  D. Cardinali,et al.  Time-dependency for the bimodal effect of melatonin on calcium uptake in rat hypothalamus , 2005, Journal of Neural Transmission / General Section JNT.

[85]  L. Wetterberg,et al.  Urinary melatonin levels in human breast cancer patients , 2005, Journal of Neural Transmission.

[86]  Gregory Belenky,et al.  Daytime sleep and performance following a zolpidem and melatonin cocktail. , 2005, Sleep.

[87]  E. Kılıç,et al.  Prophylactic use of melatonin protects against focal cerebral ischemia in mice: role of endothelin converting enzyme‐1 , 2004, Journal of pineal research.

[88]  M. Karásek.  Melatonin, human aging, and age-related diseases , 2004, Experimental Gerontology.

[89]  M. Dubocovich,et al.  Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[90]  A. Slominski,et al.  Expression of genes coding melatonin and serotonin receptors in rodent skin. , 2004, Biochimica et biophysica acta.

[91]  M. J. Jarzynka,et al.  Knock-down of RGS4 and beta tubulin in CHO cells expressing the human MT1 melatonin receptor prevents melatonin-induced receptor desensitization. , 2004, Life sciences.

[92]  S. Udin,et al.  Localization of Mel1b melatonin receptor-like immunoreactivity in ocular tissues of Xenopus laevis. , 2004, Experimental eye research.

[93]  T. Malek,et al.  Tolerance, not immunity, crucially depends on IL-2 , 2004, Nature Reviews Immunology.

[94]  Josep M. Guerrero,et al.  mRNA expression of nuclear receptor RZR/RORα, melatonin membrane receptor MT1, and hydroxindole‐O‐methyltransferase in different populations of human immune cells , 2004, Journal of pineal research.

[95]  I. Sumaya,et al.  Circadian-dependent effect of melatonin on dopaminergic D2 antagonist-induced hypokinesia and agonist-induced stereotypies in rats , 2004, Pharmacology Biochemistry and Behavior.

[96]  M. Dubocovich,et al.  Melatonin-mediated regulation of human MT(1) melatonin receptors expressed in mammalian cells. , 2004, Biochemical pharmacology.

[97]  M. Rollag,et al.  MT‐1 melatonin receptor expression increases the antiproliferative effect of melatonin on S‐91 murine melanoma cells , 2004, Journal of pineal research.

[98]  A. Carrillo-Vico,et al.  Expression of membrane and nuclear melatonin receptors in mouse peripheral organs. , 2004, Life sciences.

[99]  Josep M. Guerrero,et al.  Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[100]  S. Daniels,et al.  Blood pressure response to melatonin in type 1 diabetes , 2004, Pediatric diabetes.

[101]  G. Tosini,et al.  Localization of Aa-nat mRNA in the rat retina by fluorescence in situ hybridization and laser capture microdissection , 2004, Cell and Tissue Research.

[102]  F. Scheer,et al.  Daily Nighttime Melatonin Reduces Blood Pressure in Male Patients With Essential Hypertension , 2004, Hypertension.

[103]  N. Zisapel,et al.  Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy. , 2004, The American journal of medicine.

[104]  T. Thalhammer,et al.  The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia , 2004, Journal of pineal research.

[105]  G. Bubenik.  REVIEW: Gastrointestinal Melatonin: Localization, Function, and Clinical Relevance , 2002, Digestive Diseases and Sciences.

[106]  Nava Zisapel,et al.  Melatonin–Dopamine Interactions: From Basic Neurochemistry to a Clinical Setting , 2001, Cellular and Molecular Neurobiology.

[107]  L. Niles,et al.  Picomolar-affinity binding and inhibition of adenylate cyclase activity by melatonin in syrian hamster hypothalamus , 1990, Cellular and Molecular Neurobiology.

[108]  B. Malpaux,et al.  Origin of cerebrospinal fluid melatonin and possible function in the integration of photoperiod. , 2019, Reproduction (Cambridge, England) Supplement.

[109]  H. Kıratlı,et al.  Serum melatonin levels following enucleation and transpupillary thermotherapy in patients with choroidal melanoma , 2003, Clinical & experimental ophthalmology.

[110]  S. Shiu,et al.  Melatonin slowed the early biochemical progression of hormone‐refractory prostate cancer in a patient whose prostate tumor tissue expressed MT1 receptor subtype , 2003, Journal of pineal research.

[111]  A. Carrillo-Vico,et al.  Expression of membrane and nuclear melatonin receptor mRNA and protein in the mouse immune system , 2003, Cellular and Molecular Life Sciences CMLS.

[112]  W. Kamphorst,et al.  Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels , 2003, Journal of pineal research.

[113]  Gregory M. Brown,et al.  AII amacrine cells express the MT1 melatonin receptor in human and macaque retina. , 2003, Experimental eye research.

[114]  S. Endo,et al.  Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. , 2003, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.

[115]  J. Rada,et al.  Melatonin receptor expression in the cornea and sclera. , 2003, Experimental eye research.

[116]  T. Thalhammer,et al.  The melatonin receptor subtype MT2 is present in the human cardiovascular system , 2003, Journal of pineal research.

[117]  M. Dubocovich,et al.  Regulation of basal rhythmicity in protein kinase C activity by melatonin in immortalized rat suprachiasmatic nucleus cells , 2003, Neuroscience Letters.

[118]  D. Tobin,et al.  Functional activity of serotoninergic and melatoninergic systems expressed in the skin , 2003, Journal of cellular physiology.

[119]  D. Vesole,et al.  IL-2-based immunotherapy after autologous transplantation for lymphoma and breast cancer induces immune activation and cytokine release: a phase I/II trial , 2003, Bone Marrow Transplantation.

[120]  Francine Laden,et al.  Night-shift work and risk of colorectal cancer in the nurses' health study. , 2003, Journal of the National Cancer Institute.

[121]  M. Sjöblom,et al.  Melatonin-induced calcium signaling in clusters of human and rat duodenal enterocytes. , 2003, American journal of physiology. Gastrointestinal and liver physiology.

[122]  J. Lönnqvist,et al.  Effect of controlled-release melatonin on sleep quality, mood, and quality of life in subjects with seasonal or weather-associated changes in mood and behaviour , 2003, European Neuropsychopharmacology.

[123]  M. Aktoz,et al.  Decreased nocturnal synthesis of melatonin in patients with coronary artery disease. , 2003, International journal of cardiology.

[124]  Valter Tucci,et al.  Melatonin, circadian rhythms, and sleep , 2003, Current treatment options in neurology.

[125]  M. J. Jarzynka,et al.  Melatonin receptors and their regulation: biochemical and structural mechanisms. , 2003, Life sciences.

[126]  L. K. Yerneni.  Pharmacological action of high doses of melatonin on B16 murine melanoma cells depends on cell number at time of exposure , 2003, Melanoma research.

[127]  M. Visconti,et al.  Melatonin biological activity and binding sites in human melanoma cells , 2003, Journal of pineal research.

[128]  M. Sjöblom,et al.  Melatonin in the duodenal lumen is a potent stimulant of mucosal bicarbonate secretion , 2003, Journal of pineal research.

[129]  M. Vaghi,et al.  Biomodulation of cancer chemotherapy for metastatic colorectal cancer: a randomized study of weekly low-dose irinotecan alone versus irinotecan plus the oncostatic pineal hormone melatonin in metastatic colorectal cancer patients progressing on 5-fluorouracil-containing combinations. , 2003, Anticancer research.

[130]  M. Dubocovich,et al.  Short-Term Exposure to Melatonin Differentially Affects the Functional Sensitivity and Trafficking of the hMT1 and hMT2 Melatonin Receptors , 2003, Journal of Pharmacology and Experimental Therapeutics.

[131]  J. Pintor,et al.  Ocular hypotensive effects of melatonin receptor agonists in the rabbit: further evidence for an MT3 receptor , 2003, British journal of pharmacology.

[132]  D. Acuña-Castroviejo,et al.  Calreticulin-melatonin. An unexpected relationship. , 2003, European journal of biochemistry.

[133]  V. Gribkoff,et al.  Targeted Disruption of the Mouse Mel1b Melatonin Receptor , 2003, Molecular and Cellular Biology.

[134]  N. Zisapel,et al.  Impaired nocturnal melatonin secretion in non-dipper hypertensive patients. , 2003, Blood pressure.

[135]  J. Stachura,et al.  Role of endogenous melatonin and its MT2 receptor in the modulation of caerulein-induced pancreatitis in the rat. , 2002, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[136]  I. Zhdanova,et al.  Melatonin alters behavior and cAMP levels in nucleus accumbens induced by cocaine treatment , 2002, Brain Research.

[137]  K. Sharkey,et al.  Bright light, dark and melatonin can promote circadian adaptation in night shift workers. , 2002, Sleep medicine reviews.

[138]  W. Young,et al.  Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87). , 2002, The Journal of clinical endocrinology and metabolism.

[139]  H. Lôo,et al.  Determination of the dose of agomelatine, a melatoninergic agonist and selective 5-HT2C antagonist, in the treatment of major depressive disorder: a placebo-controlled dose range study , 2002, International clinical psychopharmacology.

[140]  M. Dubocovich,et al.  MT(2) melatonin receptors are present and functional in rat caudal artery. , 2002, The Journal of pharmacology and experimental therapeutics.

[141]  M. Dubocovich,et al.  MT1 melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells , 2002, Molecular and Cellular Endocrinology.

[142]  G. Maestroni,et al.  Melatonin in Rheumatoid Arthritis , 2002 .

[143]  B. Kos-Kudła,et al.  Circadian rhythm of melatonin in patients with colorectal carcinoma. , 2002, Neuro endocrinology letters.

[144]  D. Tobin,et al.  Serotoninergic and melatoninergic systems are fully expressed in human skin , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[145]  Prahlad T. Ram,et al.  Involvement of the mt1 melatonin receptor in human breast cancer. , 2002, Cancer letters.

[146]  D. Weaver,et al.  Mammalian melatonin receptors: molecular biology and signal transduction , 2002, Cell and Tissue Research.

[147]  Vijayalaxmi,et al.  Melatonin: from basic research to cancer treatment clinics. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[148]  Meng‐chao Wu,et al.  Patients with advanced primary hepatocellular carcinoma treated by melatonin and transcatheter arterial chemoembolization: a prospective study. , 2002, Hepatobiliary & pancreatic diseases international : HBPD INT.

[149]  N. Zisapel,et al.  Nuclear exclusion of the androgen receptor by melatonin , 2002, The Journal of Steroid Biochemistry and Molecular Biology.

[150]  N. Zisapel,et al.  Differential regulation by melatonin of cell growth and androgen receptor binding to the androgen response element in prostate cancer cells. , 2002, Neuro endocrinology letters.

[151]  G. Tarzia,et al.  Effects of melatonin and melatonin receptors ligand N-[(4-methoxy-1H-indol-2-yl)methyl]propanamide on murine Colon 38 cancer growth in vitro and in vivo. , 2002, Neuro endocrinology letters.

[152]  A. Wirz-Justice,et al.  Distribution of Melatonin MT1 Receptor Immunoreactivity in Human Retina , 2002, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[153]  M. Dubocovich,et al.  Constitutively active melatonin MT(1) receptors in male rat caudal arteries. , 2002, European journal of pharmacology.

[154]  T. Voyno-Yasenetskaya,et al.  Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins. , 2002, Cellular signalling.

[155]  Gregory M. Brown,et al.  MT(1) melatonin receptor in the human retina: expression and localization. , 2002, Investigative ophthalmology & visual science.

[156]  Deepshikha K Passey,et al.  Dual coupling of MT(1) and MT(2) melatonin receptors to cyclic AMP and phosphoinositide signal transduction cascades and their regulation following melatonin exposure. , 2002, Biochemical pharmacology.

[157]  D. Berson,et al.  Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock , 2002, Science.

[158]  R. Haque,et al.  Retinal melatonin production: role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase. , 2002, Investigative ophthalmology & visual science.

[159]  D. Blask,et al.  Melatonin as a chronobiotic/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy. , 2002, Current topics in medicinal chemistry.

[160]  R. Ravid,et al.  Increased melatonin 1a‐receptor immunoreactivity in the hippocampus of Alzheimer's disease patients , 2002, Journal of pineal research.

[161]  E. Speckmann,et al.  Melatonin receptors in rat hippocampus: molecular and functional investigations , 2002, Hippocampus.

[162]  N. Zisapel,et al.  Evaluation of signal transduction pathways mediating the nuclear exclusion of the androgen receptor by melatonin , 2001, Cellular and Molecular Life Sciences CMLS.

[163]  M. Dubocovich,et al.  Melatonin Receptor Signaling: Finding the Path Through the Dark , 2001, Science's STKE.

[164]  D. Lewis,et al.  Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices , 2001, Journal of pineal research.

[165]  G. Brown,et al.  Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin. , 2001, Endocrinology.

[166]  Anna Wirz-Justice,et al.  Circadian Clues to Sleep Onset Mechanisms , 2001, Neuropsychopharmacology.

[167]  M. Singh,et al.  Evaluation of skin sensitization potential of melatonin and nimesulide by murine local lymph node assay. , 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[168]  H. Klocker,et al.  Melatonin elicits nuclear exclusion of the human androgen receptor and attenuates its activity , 2001, The Prostate.

[169]  Josephine Arendt,et al.  Health in a 24-h society , 2001, The Lancet.

[170]  Y. Saito,et al.  Effects of melatonin on the proliferation and cis-diamminedichloroplatinum (CDDP) sensitivity of cultured human ovarian cancer cells. , 2001, Gynecologic oncology.

[171]  R. Nelson,et al.  Melatonin Receptor Subtype MT2 (Mel 1b) and Not mt1 (Mel 1a) Is Associated with Melatonin-Induced Enhancement of Cell-Mediated and Humoral Immunity , 2001, Neuroendocrinology.

[172]  K. Neve,et al.  Regulation of melatonin 1a receptor signaling and trafficking by asparagine-124. , 2001, Molecular endocrinology.

[173]  F. Mailliet,et al.  Comparative effects of melatonin, zolpidem and diazepam on sleep, body temperature, blood pressure and heart rate measured by radiotelemetry in Wistar rats , 2001, Psychopharmacology.

[174]  P. Pévet,et al.  The Circadian Clock, Light/Dark Cycle and Melatonin Are Differentially Involved in the Expression of Daily and Photoperiodic Variations in mt1 Melatonin Receptors in the Siberian and Syrian Hamsters , 2001, Neuroendocrinology.

[175]  B. C. Kim,et al.  Melatonin reduces X-ray irradiation-induced oxidative damages in cultured human skin fibroblasts. , 2001, Journal of dermatological science.

[176]  V. Motilva,et al.  New issues about melatonin and its effects on the digestive system. , 2001, Current pharmaceutical design.

[177]  G. Ramadori,et al.  Presence of melatonin in the human hepatobiliary-gastrointestinal tract. , 2001, Life sciences.

[178]  O. Nosjean,et al.  Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2 . , 2001, Biochemical pharmacology.

[179]  T. Hünig,et al.  Control of T cell hyperactivation in IL‐2‐deficient mice by CD4+CD25– and CD4+CD25+ T cells: evidence for two distinct regulatory mechanisms , 2001, European journal of immunology.

[180]  R. Armitage,et al.  Sleep EEG, depression and gender. , 2001, Sleep medicine reviews.

[181]  M. J. Jarzynka,et al.  Down-regulation of mt1 melatonin receptors in rat ovary following estrogen exposure. , 2001, Life sciences.

[182]  D. Blask,et al.  Melatonin inhibits fatty acid transport in inguinal fat pads of hepatoma 7288CTC-bearing and normal Buffalo rats via receptor-mediated signal transduction. , 2001, Life sciences.

[183]  R. Nelson,et al.  Melatonin enhancement of splenocyte proliferation is attenuated by luzindole, a melatonin receptor antagonist. , 2001, American journal of physiology. Regulatory, integrative and comparative physiology.

[184]  Y. Wong,et al.  Gα14 links a variety of Gi‐ and Gs‐coupled receptors to the stimulation of phospholipase C , 2001 .

[185]  J. Pintor,et al.  Involvement of melatonin MT(3) receptors in the regulation of intraocular pressure in rabbits. , 2001, European journal of pharmacology.

[186]  G. Maestroni.  The immunotherapeutic potential of melatonin , 2001, Expert opinion on investigational drugs.

[187]  F. Facchinetti,et al.  Effect of exogenous melatonin on vascular reactivity and nitric oxide in postmenopausal women: role of hormone replacement therapy , 2001, Clinical endocrinology.

[188]  D. Cardinali,et al.  Lack of changes in serum prolactin, FSH, TSH, and estradiol after melatonin treatment in doses that improve sleep and reduce benzodiazepine consumption in sleep‐disturbed, middle‐aged, and elderly patients , 2001, Journal of pineal research.

[189]  T. Thalhammer,et al.  24h VARIATION IN THE EXPRESSION OF THE mt1 MELATONIN RECEPTOR SUBTYPE IN CORONARY ARTERIES DERIVED FROM PATIENTS WITH CORONARY HEART DISEASE , 2001, Chronobiology international.

[190]  Y. Mei,et al.  Melatonin and its analogs potentiate the nifedipine‐sensitive high‐voltage‐activated calcium current in the chick embryonic heart cells , 2001, Journal of pineal research.

[191]  S. Shiu,et al.  Inhibition of androgen‐sensitive LNCaP prostate cancer growth in vivo by melatonin: Association of antiproliferative action of the pineal hormone with mt1 receptor protein expression , 2001, The Prostate.

[192]  T. Thalhammer,et al.  EXPRESSION OF THE MT1 MELATONIN RECEPTOR SUBTYPE IN HUMAN CORONARY ARTERIES , 2001, Journal of receptor and signal transduction research.

[193]  D. Mecke,et al.  Analysis of Melatonin in Patients with Cancer of the Reproductive System , 2001 .

[194]  N. Zisapel,et al.  Circadian Rhythm Sleep Disorders , 2001, CNS drugs.

[195]  Christian Bartsch,et al.  The Pineal Gland and Cancer , 2001, Springer Berlin Heidelberg.

[196]  M. Dubocovich,et al.  Activation of MT(2) melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock. , 2001, American journal of physiology. Cell physiology.

[197]  D. Mecke,et al.  Effect of melatonin and pineal extracts on human ovarian and mammary tumor cells in a chemosensitivity assay. , 2000, Life sciences.

[198]  A. Lewy,et al.  Entrainment of free-running circadian rhythms by melatonin in blind people. , 2000, The New England journal of medicine.

[199]  O. Nosjean,et al.  Identification of the Melatonin-binding SiteMT 3 as the Quinone Reductase 2* , 2000, The Journal of Biological Chemistry.

[200]  D. Cardinali,et al.  Low urinary 6‐sulphatoxymelatonin levels in patients with coronary artery disease , 2000, Journal of pineal research.

[201]  Josep M. Guerrero,et al.  Correlation between nuclear melatonin receptor expression and enhanced cytokine production in human lymphocytic and monocytic cell lines , 2000, Journal of pineal research.

[202]  D. Olive,et al.  Pilot study of immunotherapy with interleukin-2 after autologous stem cell transplantation in advanced breast cancers. , 2000, Anticancer research.

[203]  F. Gauer,et al.  Photic Regulation of mt1 Melatonin Receptors and 2-Iodomelatonin Binding in the Rat and Siberian Hamster , 2000, Neurosignals.

[204]  G. Tosini,et al.  Dopamine inhibits melatonin release in the mammalian retina: in vitro evidence , 2000, Neuroscience Letters.

[205]  G. Cornelissen,et al.  Nocturnal melatonin patterns in children. , 2000, The Journal of clinical endocrinology and metabolism.

[206]  G. Maestroni,et al.  Evidence for melatonin synthesis in mouse and human bone marrow cells , 2000, Journal of pineal research.

[207]  M. Melan,et al.  Melatonin decreases cell proliferation and transformation in a melatonin receptor-dependent manner. , 2000, Cancer letters.

[208]  M. Dubocovich,et al.  Circadian rhythm of mt1 melatonin receptor expression in the suprachiasmatic nucleus of the C3H/HeN mouse 1 , 2000, Journal of pineal research.

[209]  D. Hu,et al.  Melatonin receptors in human uveal melanocytes and melanoma cells , 2000, Journal of pineal research.

[210]  R. Rosenstein,et al.  Dopamine decreases melatonin content in golden hamster retina. , 2000, The Journal of pharmacology and experimental therapeutics.

[211]  Schuster,et al.  Photic Regulation of mt1 Melatonin Receptors in the Siberian Hamster Pars Tuberalis and Suprachiasmatic Nuclei: Involvement of the Circadian Clock and Intergeniculate Leaflet , 2000, Journal of neuroendocrinology.

[212]  R. Sircar.  Effect of melatonin on cocaine-induced behavioral sensitization , 2000, Brain Research.

[213]  G. Brown,et al.  Dopaminergic and GABAergic amacrine cells are direct targets of melatonin: Immunocytochemical study of mt1 melatonin receptor in guinea pig retina , 2000, Visual Neuroscience.

[214]  A. Coenen,et al.  Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome. , 2000, Journal of psychosomatic research.

[215]  M. Karásek,et al.  Serum melatonin circadian profile in women suffering from the genital tract cancers. , 2000, Neuro endocrinology letters.

[216]  D. Cardinali,et al.  Melatonin treatment stabilizes chronobiologic and cognitive symptoms in Alzheimer's disease. , 2000, Neuro endocrinology letters.

[217]  M. Farriol,et al.  In vitro effects of melatonin on cell proliferation in a colon adenocarcinoma line , 2000, Journal of applied toxicology : JAT.

[218]  A. Strosberg,et al.  Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins. , 1999, Molecular endocrinology.

[219]  N. Zisapel,et al.  Facilitation of benzodiazepine discontinuation by melatonin: a new clinical approach. , 1999, Archives of internal medicine.

[220]  A. Strosberg,et al.  Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity. , 1999, Molecular pharmacology.

[221]  R. Reiter,et al.  High physiological levels of melatonin in the bile of mammals. , 1999, Life sciences.

[222]  L. Niles,et al.  Melatonin receptor mRNA expression in human granulosa cells , 1999, Molecular and Cellular Endocrinology.

[223]  D. Blask,et al.  Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events. , 1999, Cancer research.

[224]  G. Brown,et al.  Expression of mt1 melatonin receptor in rat retina: evidence for multiple cell targets for melatonin , 1999, Neuroscience.

[225]  S. Cos,et al.  Melatonin increases p53 and p21WAF1 expression in MCF-7 human breast cancer cells in vitro. , 1999, Life sciences.

[226]  N. Zisapel,et al.  Melatonin receptors in PC3 human prostate tumor cells , 1999, Journal of pineal research.

[227]  A. Cagnacci,et al.  Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men. , 1999, The American journal of cardiology.

[228]  D. Klein,et al.  Melatonin synthesis pathway: circadian regulation of the genes encoding the key enzymes in the chicken pineal gland and retina. , 1999, Reproduction, nutrition, development.

[229]  P. S. Lazo,et al.  Melatonin blocks the activation of estrogen receptor for DNA binding , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[230]  J. Barrett,et al.  The oncostatic action of melatonin in an ovarian carcinoma cell line , 1999, Journal of pineal research.

[231]  A. Cesarani,et al.  Melatonin Influences Human Balance , 1999, Neurosignals.

[232]  D. Dawson,et al.  Thermoregulatory and soporific effects of very low dose melatonin injection. , 1999, American journal of physiology. Endocrinology and metabolism.

[233]  N. Zisapel,et al.  Hormonal interactions in human prostate tumor LNCaP cells , 1999, The Journal of Steroid Biochemistry and Molecular Biology.

[234]  M. Gillette,et al.  Suprachiasmatic nucleus: the brain's circadian clock. , 1999, Recent progress in hormone research.

[235]  H. Bartsch,et al.  Melatonin in cancer patients and in tumor-bearing animals. , 1999, Advances in experimental medicine and biology.

[236]  P. Lissoni.  The pineal gland as a central regulator of cytokine network. , 1999, Neuro endocrinology letters.

[237]  P. Pévet,et al.  Daily and circadian expression patterns of mt1 melatonin receptor mRNA in the rat pars tuberalis. , 1999, Advances in experimental medicine and biology.

[238]  N. Zisapel,et al.  Involvement of cGMP in cellular melatonin responses. , 1999, Biology of the cell.

[239]  M. Dubocovich,et al.  Melatonin receptor subtype expression in human cerebellum. , 1998, Neuroreport.

[240]  D. Cardinali,et al.  Monozygotic twins with Alzheimer's disease treated with melatonin: Case report , 1998, Journal of pineal research.

[241]  Josep M. Guerrero,et al.  Reactive Oxygen Intermediates, Molecular Damage, and Aging: Relation to Melatonin , 1998, Annals of the New York Academy of Sciences.

[242]  G. Tonini,et al.  Adjuvant treatment of breast cancer: A pilot immunochemotherapy study with CMF, interleukin-2 and interferon alpha , 1998, Cancer Immunology, Immunotherapy.

[243]  S. Cos,et al.  Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. , 1998, Cancer research.

[244]  D. Cardinali,et al.  Basic aspects of melatonin action. , 1998, Sleep medicine reviews.

[245]  L. Grunhaus,et al.  Melatonin for the treatment of sleep disturbances in major depressive disorder. , 1998, The American journal of psychiatry.

[246]  R. Huber,et al.  Effect of melatonin on sleep and brain temperature in the Djungarian hamster and the rat , 1998, Physiology & Behavior.

[247]  N. Ishida,et al.  The localization of the site of arylalkylamine N-acetyltransferase circadian expression in the photoreceptor cells of mammalian retina. , 1998, Biochemical and biophysical research communications.

[248]  S. Mccormick,et al.  Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells , 1998, Melanoma research.

[249]  A. M. Poon,et al.  Effect of melatonin on chloride secretion by human colonic T84 cells. , 1998, Life sciences.

[250]  M. Menaker,et al.  The clock in the mouse retina: melatonin synthesis and photoreceptor degeneration , 1998, Brain Research.

[251]  N. Zisapel,et al.  Melatonin receptors in benign prostate epithelial cells: Evidence for the involvement of cholera and pertussis toxins–sensitive G proteins in their signal transduction pathways , 1998, The Prostate.

[252]  D. Krause,et al.  Effect of melatonin in the rat tail artery: role of K+ channels and endothelial factors , 1998, British journal of pharmacology.

[253]  N. Zisapel,et al.  Evidence for a local action of melatonin on the rat prostate. , 1998, The Journal of urology.

[254]  D. Klein,et al.  Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation. , 1998, Science.

[255]  N. Zisapel,et al.  A role for NAD+ and cADP-ribose in melatonin signal transduction , 1998, Molecular and Cellular Endocrinology.

[256]  J. Cipolla-Neto,et al.  The effect of melatonin chronic treatment upon macrophage and lymphocyte metabolism and function in Walker-256 tumour-bearing rats , 1998, Journal of Neuroimmunology.

[257]  O. Puciłowski,et al.  Effects of melatonin receptor ligands on swim test immobility , 1998, Neuroreport.

[258]  S. Ying,et al.  Chronic exposure to melatonin receptor agonists does not alter their effects on suprachiasmatic nucleus neurons. , 1998, European journal of pharmacology.

[259]  A. Lewy,et al.  Melatonin treatment of winter depression: a pilot study , 1998, Psychiatry Research.

[260]  A. Kalsbeek,et al.  The suprachiasmatic nucleus-paraventricular nucleus interactions: a bridge to the neuroendocrine and autonomic nervous system. , 1998, Progress in brain research.

[261]  D. Dijk,et al.  Melatonin and the Circadian Regulation of Sleep Initiation, Consolidation, Structure, and the Sleep EEG , 1997, Journal of biological rhythms.

[262]  D. Cardinali,et al.  Effects of melatonin in elderly patients with sleep disturbance: a pilot study , 1997 .

[263]  B. Middleton,et al.  Complex Effects of Melatonin on Human Circadian Rhythms in Constant Dim Light , 1997, Journal of biological rhythms.

[264]  N. Zisapel,et al.  Inactivation of melatonin receptors by protein kinase C in human prostate epithelial cells. , 1997, Endocrinology.

[265]  D. Krause,et al.  Melatonin directly constricts rat cerebral arteries through modulation of potassium channels. , 1997, The American journal of physiology.

[266]  N. Zisapel,et al.  Interplay between sex steroids and melatonin in regulation of human benign prostate epithelial cell growth. , 1997, The Journal of clinical endocrinology and metabolism.

[267]  P. Lavie,et al.  Nocturnal melatonin onset is phase locked to the primary sleep gate. , 1997, The American journal of physiology.

[268]  A. Wirz-Justice,et al.  A relationship between heat loss and sleepiness: effects of postural change and melatonin administration. , 1997, Journal of applied physiology.

[269]  V. Gribkoff,et al.  Molecular Dissection of Two Distinct Actions of Melatonin on the Suprachiasmatic Circadian Clock , 1997, Neuron.

[270]  J. Saurat,et al.  Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily. , 1997, The Journal of Biological Chemistry.

[271]  C. Verfaillie,et al.  Low dose subcutaneous interleukin-2 after autologous transplantation generates sustained in vivo natural killer cell activity. , 1997, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[272]  N. Zisapel,et al.  Improvement of sleep quality by controlled-release melatonin in benzodiazepine-treated elderly insomniacs. , 1997, Archives of gerontology and geriatrics.

[273]  M. Gillette,et al.  Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: activation of protein kinase C at dusk and dawn. , 1997, Endocrinology.

[274]  R. Willig,et al.  Melatonin and 6-hydroxymelatonin sulfate excretion is inversely correlated with gonadal development in children. , 1997, Hormone research.

[275]  S. Barni,et al.  Reversal of clinical resistance to LHRH analogue in metastatic prostate cancer by the pineal hormone melatonin: efficacy of LHRH analogue plus melatonin in patients progressing on LHRH analogue alone. , 1997, European urology.

[276]  S. Reppert,et al.  The Mel1a Melatonin Receptor Is Coupled to Parallel Signal Transduction Pathways 1. , 1997, Endocrinology.

[277]  S. Reppert,et al.  The Mel1a melatonin receptor gene is expressed in human suprachiasmatic nuclei , 1996, Neuroreport.

[278]  R H Masland,et al.  The number of unidentified amacrine cells in the mammalian retina. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[279]  J. Trouvin,et al.  Dopamine Inhibits Melatonin Synthesis in Photoreceptor Cells Through a D2‐Like Receptor Subtype in the Rat Retina: Biochemical and Histochemical Evidence , 1996, Journal of neurochemistry.

[280]  P. Pévet,et al.  Daily and Photoperiodic Melatonin Binding Changes in the Suprachiasmatic Nuclei, Paraventricular Thalamic Nuclei, and Pars Tuberalis of the Female Siberian Hamster (Phodopus sungorus) , 1996, Journal of biological rhythms.

[281]  R. Nonno,et al.  The melatonin receptor in the human brain: cloning experiments and distribution studies. , 1996, Brain research. Molecular brain research.

[282]  N. Zisapel,et al.  Putative melatonin receptors in benign human prostate tissue. , 1996, The Journal of clinical endocrinology and metabolism.

[283]  N. Zisapel,et al.  Functional melatonin receptors in human prostate epithelial cells. , 1996, Endocrinology.

[284]  L. Bianchi,et al.  Circadian photic regulation of melatonin receptor density in rat suprachiasmatic nuclei: Comparison with light induction of fos‐related protein , 1996, Journal of neuroscience research.

[285]  C. Allen,et al.  Melatonin receptors activate heteromeric G‐protein coupled Kir3 channels , 1996, Neuroreport.

[286]  P. Renard,et al.  Melatonin analogues as agonists and antagonists in the circadian system and other brain areas. , 1996, European journal of pharmacology.

[287]  A. Poon,et al.  Melatonin and 2[125I]iodomelatonin binding sites in the human colon. , 1996, Endocrine research.

[288]  A. Bird,et al.  Day-time naps and melatonin in blind people , 1995, The Lancet.

[289]  F. Mora,et al.  The modulatory effect of melatonin on the dopamine-glutamate interaction in the anterior hypothalamus during ageing. , 1995, Neuroreport.

[290]  D. Klein,et al.  Human hydroxyindole-O-methyltransferase in pineal gland, retina and Y79 retinoblastoma cells , 1995, Brain Research.

[291]  L. Ferini-Strambi,et al.  Triazolam and melatonin effects on cardiac autonomic function during sleep. , 1995, Clinical neuropharmacology.

[292]  J. Gusella,et al.  Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[293]  P. Lavie,et al.  Melatonin replacement therapy of elderly insomniacs. , 1995, Sleep.

[294]  N. Zisapel,et al.  Improvement of sleep quality in elderly people by controlled-release melatonin , 1995, The Lancet.

[295]  C. Allen,et al.  Melatonin activates an outward current and inhibits I h in rat suprachiasmatic nucleus neurons , 1995, Brain Research.

[296]  S. Shiu,et al.  Regional and diurnal studies of melatonin and melatonin binding sites in the duck gastro-intestinal tract. , 1995, Biological signals.

[297]  H. Griesser,et al.  Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. , 1995, Science.

[298]  M. Herold,et al.  Impaired nocturnal secretion of melatonin in coronary heart disease , 1995, The Lancet.

[299]  N. Zisapel,et al.  Effects of long-term administration of melatonin and a putative antagonist on the ageing rat. , 1995, Neuroreport.

[300]  R. Hagan,et al.  Melatonin comes of age? , 1995, Trends in pharmacological sciences.

[301]  J. Gan,et al.  Functional interaction of melatonin receptors and D1 dopamine receptors in cultured chick retinal neurons , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[302]  I. Rodriguez,et al.  Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters. , 1994, The Journal of biological chemistry.

[303]  S. Hill,et al.  Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells. , 1994, Molecular endocrinology.

[304]  S. Reppert,et al.  Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses , 1994, Neuron.

[305]  M. Hastings,et al.  Melatonin Regulates the Phosphorylation of CREB in Ovine Pars Tuberalis * , 1994, Journal of neuroendocrinology.

[306]  P. Lavie,et al.  Sleep disorders and melatonin rhythms in elderly people , 1994, BMJ.

[307]  N. Osborne,et al.  The presence of functional melatonin receptors in the iris-ciliary processes of the rabbit eye. , 1994, Experimental eye research.

[308]  R. Wurtman,et al.  Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[309]  P. Morgan,et al.  Melatonin receptors: Localization, molecular pharmacology and physiological significance , 1994, Neurochemistry International.

[310]  L. Niles,et al.  Physiological regulation of melatonin receptors in rat suprachiasmatic nuclei: diurnal rhythmicity and effects of stress , 1993, Molecular and Cellular Endocrinology.

[311]  S. Barni,et al.  Subcutaneous Therapy with Low-Dose Interleukin-2 plus the Neurohormone Melatonin in Metastatic Gastric Cancer Patients with Low Performance Status , 1993, Tumori.

[312]  M. Bernard,et al.  Characterization of melatonin binding sites in chicken and human intestines. , 1993, European journal of pharmacology.

[313]  R. Reiter,et al.  The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances , 1993, Neuroscience & Biobehavioral Reviews.

[314]  M. Becker‐André,et al.  Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences. , 1993, Biochemical and biophysical research communications.

[315]  S. Pang,et al.  Melatonin and its receptors in the gastrointestinal tract. , 1993, Biological signals.

[316]  S. Barni,et al.  Immunotherapy with subcutaneous low-dose interleukin-2 and the pineal indole melatonin as a new effective therapy in advanced cancers of the digestive tract. , 1993, British Journal of Cancer.

[317]  G. Maestroni.  The immunoneuroendocrine role of melatonin , 1993, Journal of pineal research.

[318]  S. Folkard,et al.  Can melatonin improve shift workers' tolerance of the night shift? Some preliminary findings. , 1993, Chronobiology international.

[319]  M. Hastings,et al.  Prolonged exposure to melatonin leads to time-dependent sensitization of adenylate cyclase and down-regulates melatonin receptors in pars tuberalis cells from ovine pituitary. , 1993, Endocrinology.

[320]  D. Skene,et al.  Daily rhythms of melatonin binding sites in the rat pars tuberalis and suprachiasmatic nuclei; evidence for a regulation of melatonin receptors by melatonin itself. , 1993, Neuroendocrinology.

[321]  S. Hill,et al.  Melatonin decreases estrogen receptor expression in the medial preoptic area of inbred (LSH/SsLak) golden hamsters. , 1992, Biology of reproduction.

[322]  R. Weiler,et al.  Dopaminergic modulation of gap junction permeability between amacrine cells in mammalian retina , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[323]  F. Gauer,et al.  Pinealectomy and constant illumination increase the density of melatonin binding sites in the pars tuberalis of rodents , 1992, Brain Research.

[324]  A. Cavallo.  Melatonin secretion during adrenarche in normal human puberty and in pubertal disorders , 1992, Journal of pineal research.

[325]  A. Lewy,et al.  Melatonin shifts human circadian rhythms according to a phase-response curve. , 1992, Chronobiology international.

[326]  J. Parkes,et al.  Delayed sleep phase syndrome response to melatonin , 1991, The Lancet.

[327]  S. Cos,et al.  Effects of melatonin on the cell cycle kinetics and “estrogen‐rescue” of MCF‐7 human breast cancer cells in culture , 1991, Journal of pineal research.

[328]  R. Silman.  Melatonin and the human gonadotrophin-releasing hormone pulse generator. , 1991, The Journal of endocrinology.

[329]  M. Dubocovich,et al.  Regulatory sites in the melatonin system of mammals , 1990, Trends in Neurosciences.

[330]  J. Vanecek,et al.  Daily changes in melatonin binding sites and the effect of castration , 1990, Molecular and Cellular Endocrinology.

[331]  O. Vakkuri,et al.  Circadian and seasonal variation in human preovulatory follicular fluid melatonin concentration. , 1990, The Journal of clinical endocrinology and metabolism.

[332]  J. Laitinen,et al.  Expression of melatonin receptors in arteries involved in thermoregulation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[333]  N. Kerenyi,et al.  Oncostatic effects of the pineal gland. , 1990, Drug metabolism and drug interactions.

[334]  N. Zisapel,et al.  Diurnal variations in melatonin binding sites in the hamster brain: impact of melatonin , 1989, Molecular and Cellular Endocrinology.

[335]  S. Hill,et al.  Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. , 1988, Cancer research.

[336]  N. Zisapel,et al.  Melatonin receptors in discrete brain areas of the male rat. Impact of aging on density and on circadian rhythmicity. , 1988, Neuroendocrinology.

[337]  M. Schemper,et al.  Alterations in nocturnal serum melatonin levels in humans with growth and aging. , 1988, The Journal of clinical endocrinology and metabolism.

[338]  N. Zisapel,et al.  Regulation of melatonin's activity in the female rat brain by estradiol: effects on neurotransmitter release and on iodomelatonin binding sites. , 1987, Neuroendocrinology.

[339]  D. Klein,et al.  Activation of alpha 1-adrenoceptors, protein kinase C, or treatment with intracellular free Ca2+ elevating agents increases pineal phospholipase A2 activity. Evidence that protein kinase C may participate in Ca2+-dependent alpha 1-adrenergic stimulation of pineal phospholipase A2 activity. , 1987, The Journal of biological chemistry.

[340]  N. Zisapel,et al.  Impact of circulating estradiol on melatonin binding sites in discrete areas of the female rat brain , 1987, Brain Research.

[341]  R. Wurtman,et al.  Melatonin in human preovulatory follicular fluid. , 1987, The Journal of clinical endocrinology and metabolism.

[342]  G. Maestroni,et al.  Role of the pineal gland in immunity Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone , 1986, Journal of Neuroimmunology.

[343]  N. Zisapel,et al.  Characterization of central melatonin receptors using 125I‐melatonin , 1986, FEBS letters.

[344]  M. Dubocovich.  N-Acetyltryptamine antagonizes the melatonin-induced inhibition of [3H]dopamine release from retina. , 1984, European journal of pharmacology.

[345]  D. Cardinali,et al.  Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes , 1984, Brain Research.

[346]  N. Zisapel,et al.  Inhibition by melatonin of dopamine release from rat hypothalamus: regulation of calcium entry , 1983, Brain Research.

[347]  J. Redman,et al.  Free-running activity rhythms in the rat: entrainment by melatonin. , 1983, Science.

[348]  M. Dubocovich.  Melatonin is a potent modulator of dopamine release in the retina , 1983, Nature.

[349]  M. Lippman,et al.  Decreased nocturnal plasma melatonin peak in patients with estrogen receptor positive breast cancer. , 1982, Science.

[350]  N. Zisapel,et al.  Dopamine release induced by electrical field stimulation of rat hypothalamus in vitro: inhibition by melatonin. , 1982, Biochemical and biophysical research communications.

[351]  D. Cardinali,et al.  Molecular Endocrinology of Melatonin: Receptor Sites in Brain and Peripheral Organs , 1981 .

[352]  D. Cardinali,et al.  Dihydroergocryptine binding sites in bovine and rat pineal glands. , 1980, Journal of the autonomic nervous system.

[353]  R. Reiter.  The pineal and its hormones in the control of reproduction in mammals. , 1980, Endocrine reviews.

[354]  D. Cardinali,et al.  Diurnal changes in melatonin binding sites of hamster and rat brains. Correlation with neuroendocrine responsiveness to melatonin , 1979, Neuroscience Letters.

[355]  D. Klein,et al.  Pineal N-acetyltransferase and hydroxyindole-O-methyl-transferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus , 1979, Brain Research.

[356]  F. Goodwin,et al.  Tricyclics modulate frequency of mood cycles. , 1979, Chronobiologia.

[357]  I. Karacan,et al.  Sleep Disorders: Diagnosis and Treatment , 1999 .

[358]  N. Raikhlin,et al.  Melatonin and enterochromaffine cells. , 1976, Acta histochemica.

[359]  D. Cardinali,et al.  Melatonin effects on brain. Interaction with microtubule protein, inhibition of fast axoplasmic flow and induction of crystaloid and tubular formations in the hypothalamus , 1975, Molecular and Cellular Endocrinology.

[360]  P. Hauri.  SLEEP IN DEPRESSION , 1974 .

[361]  F. Hirata,et al.  In vitro and in vivo formation of two new metabolites of melatonin. , 1974, The Journal of biological chemistry.

[362]  D. Klein,et al.  Melatonin metabolism: neural regulation of pineal serotonin: acetyl coenzyme A N-acetyltransferase activity. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[363]  D. Cardinali,et al.  Metabolism of serotonin by the rat retina in vitro , 1971, Journal of neurochemistry.

[364]  D. Cardinali,et al.  Retinal localization of the hydroxyindole-O-methyl transferase (HIOMT) in the rat. , 1971, Endocrinology.

[365]  R. Wurtman,et al.  Photic and neural control of indoleamine metabolism in the rat pineal gland. , 1968, Advances in pharmacology.

[366]  A. Lerner,et al.  ISOLATION OF MELATONIN, THE PINEAL GLAND FACTOR THAT LIGHTENS MELANOCYTES1 , 1958 .