Human plasma-mediated hypoxic activation of indolequinone-based naloxone pro-drugs.
暂无分享,去创建一个
Thommey P. Thomas | J. Baker | Baohua Huang | A. Desai | Xue-min Cheng | Shengzhuang Tang | A. van der Spek | Alina E. Kotlyar
[1] D. Bloodworth. Opioids in the treatment of chronic pain: legal framework and therapeutic indications and limitations. , 2006, Physical medicine and rehabilitation clinics of North America.
[2] J. Conklin,et al. Intestinal Motility During Hypoxia and Reoxygenation in Vitro , 1997, Digestive Diseases and Sciences.
[3] D. Naughton,et al. 1H NMR studies on the reductively triggered release of heterocyclic and steroid drugs from 4,7-dioxoindole-3-methyl prodrugs , 2003 .
[4] R. Borch,et al. Studies on the mechanisms of activation of indolequinone phosphoramidate prodrugs. , 2003, Journal of medicinal chemistry.
[5] R. Borch,et al. Design, synthesis, and biological evaluation of indolequinone phosphoramidate prodrugs targeted to DT-diaphorase. , 2002, Journal of medicinal chemistry.
[6] B. Vojnovic,et al. Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: a key factor in controlling hypoxia-selective drug release. , 2002, Biochemical pharmacology.
[7] C. Moody,et al. Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2. , 2001, Journal of medicinal chemistry.
[8] D Zuder,et al. Current therapies for wound healing: electrical stimulation, biological therapeutics, and the potential for gene therapy , 1999, International journal of dermatology.
[9] I. Stratford,et al. Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships. , 1999, Journal of medicinal chemistry.
[10] C. Stevens,et al. Influence of hypoxia in inflammatory synovitis , 1998, Annals of the rheumatic diseases.
[11] P. Workman,et al. Bioreductive drugs into the next millennium. , 1998, Anti-cancer drug design.
[12] G. Adams,et al. Indolequinone antitumor agents: reductive activation and elimination from (5-methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl derivatives and hypoxia-selective cytotoxicity in vitro. , 1998, Journal of medicinal chemistry.
[13] D. Ross,et al. Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1. , 1998, Bioorganic & medicinal chemistry letters.
[14] J. Schmedtje,et al. Hypoxia and molecular cardiovascular medicine. , 1998, Trends in cardiovascular medicine.
[15] G. Adams,et al. 2-Cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: structure-activity in vitro and efficacy in vivo. , 1997, Journal of medicinal chemistry.
[16] C. Ikonomidou,et al. Excitotoxicity and neurodegenerative diseases. , 1995, Current opinion in neurology.
[17] J. Fishman,et al. Narcotic antagonists. 1. Isomeric sulfate and acetate esters of naloxone (N-allylnoroxymorphone). , 1973, Journal of medicinal chemistry.
[18] Lars Ernster. [56] DT diaphorase , 1967 .