From virtual microscopy to systems pathology

Virtual microscopy encompasses the high-resolution scanning of tissue slides and cell preparation and derived technologies including automatic digitalization and computational processing of whole microscopic slides, cytological preparations and tissue arrays, and web-based easy accessibility and analyses. For the first time, it enables highthroughput imaging and quantitative measurements of tissue structures. By integrating mass tissue data and derived analyses, virtual microscopy creates novel synergies between technological disciplines such as pathology/ histology, bioinformatics, medical informatics, image analysis, as well as cell and molecular biology. These technical synergies may pave the way for new structures in research, clinical diagnostics, education, and training and fundamentally support newly arising disciplines like medical systems biology. The 1st European Workshop on Tissue Imaging and Analysis, held in Heidelberg on 13th and 14th February 2009 intended to provide a discussion forum for multiple disciplines related to virtual microscopy, like pathology, systems biology and pathology, computer-assisted highthroughput diagnostics, cell-based cancer diagnostics, bioinformatics and image processing, and the scientific exchange of key players in the field. Over 140 participants from 10 European countries as well as USA and Japan took part in the meeting.

[1]  U-D Braumann,et al.  Large histological serial sections for computational tissue volume reconstruction. , 2007, Methods of information in medicine.

[2]  [Cytology in the internet]. , 2007, Der Pathologe.

[3]  Hartmut Dickhaus,et al.  Reconstructing protein networks of epithelial differentiation from histological sections , 2007, Bioinform..

[4]  D. Glatz,et al.  Zytologie im Internet , 2007, Der Pathologe.

[5]  N. Grabe,et al.  Virtuelle Mikroskopie in der Systempathologie , 2008, Der Pathologe.

[6]  [Virtual microscopy in pathology teaching and postgraduate training (continuing education)]. , 2008, Der Pathologe.

[7]  Skin stem cells: rising to the surface , 2008 .

[8]  P Hufnagl,et al.  [Virtual microscopy and routine diagnostics. A discussion paper]. , 2008, Der Pathologe.

[9]  Virtuelle Mikroskopie in Lehre und Ausbildung in der Pathologie , 2008, Der Pathologe.

[10]  P. Hufnagl,et al.  Virtuelle Mikroskopie und Routinediagnostik , 2008, Der Pathologe.

[11]  N. Grabe [Virtual microscopy in systems pathology]. , 2008 .

[12]  Elaine Kay,et al.  Virtual microscopy as an enabler of automated/quantitative assessment of protein expression in TMAs , 2008, Histochemistry and Cell Biology.

[13]  Peter Hufnagl,et al.  Integration and acceleration of virtual microscopy as the key to successful implementation into the routine diagnostic process , 2009, Diagnostic pathology.

[14]  M. Kloor,et al.  The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy. , 2009, Cancer immunity.

[15]  Anthony G Gallagher,et al.  Do we see what we think we see? The complexities of morphological assessment , 2009, The Journal of pathology.

[16]  C. Patel A discussion paper , 2010 .