Recent Advances in Nanotechnology Applied to Biosensors

In recent years there has been great progress the application of nanomaterials in biosensors. The importance of these to the fundamental development of biosensors has been recognized. In particular, nanomaterials such as gold nanoparticles, carbon nanotubes, magnetic nanoparticles and quantum dots have been being actively investigated for their applications in biosensors, which have become a new interdisciplinary frontier between biological detection and material science. Here we review some of the main advances in this field over the past few years, explore the application prospects, and discuss the issues, approaches, and challenges, with the aim of stimulating a broader interest in developing nanomaterial-based biosensors and improving their applications in disease diagnosis and food safety examination.

[1]  Haili Zhang,et al.  A novel hydrogen peroxide biosensor based on hemoglobin immobilized on magnetic chitosan microspheres modified electrode , 2008 .

[2]  J. Cheon,et al.  Nanoscaling laws of magnetic nanoparticles and their applicabilities in biomedical sciences. , 2008, Accounts of chemical research.

[3]  Wei Lu,et al.  Real-time detection of electron tunnelling in a quantum dot , 2003, Nature.

[4]  P. Joshi,et al.  Amperometric biosensors based on redox polymer-carbon nanotube-enzyme composites. , 2005, Analytical chemistry.

[5]  Mónica Revenga-Parra,et al.  Architectures based on the use of gold nanoparticles and ruthenium complexes as a new route to improve genosensor sensitivity. , 2008, Biosensors & bioelectronics.

[6]  Shaojun Dong,et al.  A sensitive NADH and glucose biosensor tuned by visible light based on thionine bridged carbon nanotubes and gold nanoparticles multilayer. , 2008, Biosensors & bioelectronics.

[7]  Aihua Liu Towards development of chemosensors and biosensors with metal-oxide-based nanowires or nanotubes. , 2008, Biosensors & bioelectronics.

[8]  Daxiang Cui,et al.  Study on interaction between gold nanorod and bovine serum albumin , 2007 .

[9]  Dong Wang,et al.  Controllable biotinylated poly(ethylene-co-glycidyl methacrylate) (PE-co-GMA) nanofibers to bind streptavidin-horseradish peroxidase (HRP) for potential biosensor applications , 2008 .

[10]  N. Chaniotakis,et al.  Pesticide detection with a liposome-based nano-biosensor. , 2007, Biosensors & bioelectronics.

[11]  Ruo Yuan,et al.  Amperometric immunosensors based on layer-by-layer assembly of gold nanoparticles and methylene blue on thiourea modified glassy carbon electrode for determination of human chorionic gonadotrophin. , 2008, Talanta.

[12]  Vinu Venkatraman,et al.  Fabrication of Submicron IrO2 Nanowire Array Biosensor Platform by Conventional Complementary Metal–Oxide–Semiconductor Process , 2008 .

[13]  Hidetaka Uno,et al.  Fabrication of Si-based planar type patch clamp biosensor using silicon on insulator substrate , 2008 .

[14]  P. Solanki,et al.  Sol–gel derived nanoporous cerium oxide film for application to cholesterol biosensor , 2008 .

[15]  Tao Yang,et al.  Sensitive PAT gene sequence detection by nano-SiO2/p-aminothiophenol self-assembled films DNA electrochemical biosensor based on impedance measurement , 2008 .

[16]  F. Gao,et al.  Effects of antisense-myc-conjugated single-walled carbon nanotubes on HL-60 cells. , 2007, Journal of nanoscience and nanotechnology.

[17]  Yingfu Li,et al.  Simple and rapid colorimetric enzyme sensing assays using non-crosslinking gold nanoparticle aggregation. , 2007, Chemical communications.

[18]  Cengiz S. Ozkan,et al.  Effects of Carbon Nanotubes on Photoluminescence Properties of Quantum Dots , 2008 .

[19]  M. Melloch,et al.  The Kondo Effect in an Artificial Quantum Dot Molecule , 2001, Science.

[20]  Doina Bica,et al.  Antitumor effect of magnetite nanoparticles in cat mammary adenocarcinoma , 2005 .

[21]  S Arana,et al.  Magnetoresistive immunosensor for the detection of Escherichia coli O157:H7 including a microfluidic network. , 2009, Biosensors & bioelectronics.

[22]  Ruo Yuan,et al.  A sensitive amperometric immunosensor for carcinoembryonic antigen detection with porous nanogold film and nano-Au/chitosan composite as immobilization matrix. , 2008, Journal of biochemical and biophysical methods.

[23]  Hyun Tae Kim,et al.  A novel glucose biosensor based on immobilization of glucose oxidase into multiwall carbon nanotubes-polyelectrolyte-loaded electrospun nanofibrous membrane. , 2008, Biosensors & bioelectronics.

[24]  Liwei Lin,et al.  MEMS sensor material based on polypyrrole–carbon nanotube nanocomposite: film deposition and characterization , 2005 .

[25]  Mosong Cheng,et al.  Patterning a nanowell sensor biochip for specific and rapid detection of bacteria , 2008 .

[26]  Seung-Hyeon Moon,et al.  Substrate-bound tyrosinase electrode using gold nanoparticles anchored to pyrroloquinoline quinone for a pesticide biosensor , 2008 .

[27]  M. Prins,et al.  Controlled torque on superparamagnetic beads for functional biosensors. , 2009, Biosensors & bioelectronics.

[28]  Huangxian Ju,et al.  Biofunctional nanocomposite of carbon nanofiber with water-soluble porphyrin for highly sensitive ethanol biosensing. , 2008, Biosensors & bioelectronics.

[29]  Feng Gao,et al.  Self-assembly of quantum dots and carbon nanotubes for ultrasensitive DNA and antigen detection. , 2008, Analytical chemistry.

[30]  D. Cui,et al.  Advances and prospects of gold nanorods. , 2008, Chemistry, an Asian journal.

[31]  Igor L. Medintz,et al.  Quantum dot bioconjugates for imaging, labelling and sensing , 2005, Nature materials.

[32]  Hai-Li Zhang,et al.  An amperometric hydrogen peroxide biosensor based on immobilization of horseradish peroxidase on an electrode modified with magnetic dextran microspheres , 2008, Analytical and bioanalytical chemistry.

[33]  Xi Chen,et al.  Development of acetylcholinesterase biosensor based on CdTe quantum dots/gold nanoparticles modified chitosan microspheres interface. , 2008, Biosensors & bioelectronics.

[34]  G. S. Wilson,et al.  Biosensors : fundamentals and applications , 1987 .

[35]  Qing Zhang,et al.  Porous nanosheet-based ZnO microspheres for the construction of direct electrochemical biosensors. , 2008, Biosensors & bioelectronics.

[36]  E. Wang,et al.  Simple and sensitive aptamer-based colorimetric sensing of protein using unmodified gold nanoparticle probes. , 2007, Chemical communications.

[37]  You Wang,et al.  A pyrrole quinoline quinone glucose dehydrogenase biosensor based on screen-printed carbon paste electrodes modified by carbon nanotubes , 2008 .

[38]  J. C. Rifea,et al.  Design and performance of GMR sensors for the detection of magnetic microbeads in biosensors , 2003 .

[39]  Serge Cosnier,et al.  Calcium carbonate nanoparticles: a host matrix for the construction of highly sensitive amperometric phenol biosensor. , 2007, Biosensors & bioelectronics.

[40]  Huifeng Qian,et al.  A resonance energy transfer between chemiluminescent donors and luminescent quantum-dots as acceptors (CRET). , 2006, Angewandte Chemie.

[41]  D. Cui Advances and prospects on biomolecules functionalized carbon nanotubes. , 2007, Journal of nanoscience and nanotechnology.

[42]  Fen Xu,et al.  Glucose biosensor based on electrodeposition of platinum nanoparticles onto carbon nanotubes and immobilizing enzyme with chitosan-SiO(2) sol-gel. , 2008, Biosensors & bioelectronics.

[43]  Joshua E. Smith,et al.  Gold nanoparticle-based colorimetric assay for the direct detection of cancerous cells. , 2008, Analytical chemistry.

[44]  H. S. Wolff,et al.  iRun: Horizontal and Vertical Shape of a Region-Based Graph Compression , 2022, Sensors.

[45]  Junwei Di,et al.  The promotion effect of titania nanoparticles on the direct electrochemistry of lactate dehydrogenase sol-gel modified gold electrode. , 2008, Talanta.

[46]  Hanna Radecka,et al.  Comparison of electrochemical immunosensors based on gold nano materials and immunoblot techniques for detection of histidine-tagged proteins in culture medium. , 2008, Biosensors & bioelectronics.

[47]  Kyungsoon Park,et al.  Characterization and electrocatalytic properties of Prussian blue electrochemically deposited on nano-Au/PAMAM dendrimer-modified gold electrode. , 2008, Biosensors & bioelectronics.

[48]  Mitsuru Izumi,et al.  Preparation of an enzymatic glucose sensor based on hybrid organic-inorganic Langmuir-Blodgett films : Adsorption of glucose oxidase into positively charged molecular layers , 2008 .

[49]  W. Mu,et al.  Biomolecules/gold nanowires-doped sol-gel film for label-free electrochemical immunoassay of testosterone. , 2008, Journal of biochemical and biophysical methods.

[50]  M. Shim,et al.  Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[51]  Hiroyuki Honda,et al.  The effect of RGD peptide-conjugated magnetite cationic liposomes on cell growth and cell sheet harvesting. , 2005, Biomaterials.

[52]  Syed K. Islam,et al.  A reagentless enzymatic amperometric biosensor using vertically aligned carbon nanofibers (VACNF) , 2008 .

[53]  Huajian Gao,et al.  Effects of single-walled carbon nanotubes on the polymerase chain reaction , 2003 .

[54]  Xiangqin Lin,et al.  Simultaneous determination of dopamine and serotonin on gold nanocluster/overoxidized-polypyrrole composite modified glassy carbon electrode , 2007 .

[55]  H. Muguruma,et al.  An amperometric biosensor based on a composite of single-walled carbon nanotubes, plasma-polymerized thin film, and an enzyme. , 2008, Biosensors & bioelectronics.

[56]  Ning Wang,et al.  Synthesis and characterization of waxberry-like microstructures ZnO for biosensors , 2008 .

[57]  S. Rastogi,et al.  Nanowire-transistor based ultra-sensitive DNA methylation detection. , 2008, Biosensors & bioelectronics.

[58]  Fusheng Xiong,et al.  Single-molecule detection of DNA via sequence-specific links between F1-ATPase motors and gold nanorod sensors. , 2008, Lab on a chip.

[59]  Adam Wax,et al.  Label-free plasmonic detection of biomolecular binding by a single gold nanorod. , 2008, Analytical chemistry.

[60]  Kyoung-Nam Kim,et al.  Cytotoxicity of ferrite particles by MTT and agar diffusion methods for hyperthermic application , 2005 .

[61]  Gengfeng Zheng,et al.  Nanowire-Based Nanoelectronic Devices in the Life Sciences , 2007 .

[62]  M. Wang,et al.  Nano-composite ZrO2/Au film electrode for voltammetric detection of parathion , 2008 .

[63]  Wei Zhang,et al.  Synergistic effects of nano-ZnO/multi-walled carbon nanotubes/chitosan nanocomposite membrane for the sensitive detection of sequence-specific of PAT gene and PCR amplification of NOS gene , 2008 .

[64]  Qian Wang,et al.  Toward Large Arrays of Multiplex Functionalized Carbon Nanotube Sensors for Highly Sensitive and Selective Molecular Detection. , 2003, Nano letters.

[65]  Yu Zhang,et al.  Zeta potential: a surface electrical characteristic to probe the interaction of nanoparticles with normal and cancer human breast epithelial cells , 2008, Biomedical microdevices.

[66]  Shyamsunder Erramilli,et al.  Surface-modified silicon nano-channel for urea sensing , 2008 .

[67]  B. Jena,et al.  Optical sensing of biomedically important polyionic drugs using nano-sized gold particles. , 2008, Biosensors & bioelectronics.

[68]  Kh Ghanbari,et al.  Electrochemically fabricated polypyrrole nanofiber-modified electrode as a new electrochemical DNA biosensor. , 2008, Biosensors & bioelectronics.

[69]  Javier Aizpurua,et al.  Mapping the plasmon resonances of metallic nanoantennas. , 2008, Nano letters.

[70]  Paulo C. Morais,et al.  Effects of AC magnetic field and carboxymethyldextran-coated magnetite nanoparticles on mice peritoneal cells , 2005 .

[71]  Bingling Li,et al.  Reusable, label-free electrochemical aptasensor for sensitive detection of small molecules. , 2007, Chemical communications.

[72]  Shouzhuo Yao,et al.  Amperometric glucose biosensor based on boron-doped carbon nanotubes modified electrode. , 2008, Talanta.

[73]  T. Hirano,et al.  Mortalin imaging in normal and cancer cells with quantum dot immuno-conjugates , 2003, Cell Research.

[74]  K. Fujioka,et al.  Simultaneous Multicolor Detection System of the Single‐Molecular Microbial Antigen with Total Internal Reflection Fluorescence Microscopy , 2005, Microbiology and immunology.

[75]  Ying Wang,et al.  A simple method to fabricate a Prussian Blue nanoparticles/carbon nanotubes/poly(1,2-diaminobenzene) based glucose biosensor , 2008 .

[76]  G. Shen,et al.  Amperometric H2O2 biosensor based on poly-thionine nanowire/HRP/nano-Au-modified glassy carbon electrode , 2008 .

[77]  G. A. Rechnitz,et al.  Intact chemoreceptor-based biosensors: responses and analytical limits , 1989 .

[78]  Young Jin Kim,et al.  Optical detection of DNA hybridization using absorption spectra of single-walled carbon nanotubes , 2008 .

[79]  Ahmad Musa,et al.  Use of Fe3O4 Nanoparticles for Enhancement of Biosensor Response to the Herbicide 2,4-Dichlorophenoxyacetic Acid , 2008, Sensors.

[80]  D. Gammon,et al.  An All-Optical Quantum Gate in a Semiconductor Quantum Dot , 2003, Science.

[81]  Qingjiang Wang,et al.  Amperometric method for rapid detection of Escherichia coli by flow injection analysis using a bismuth nano-film modified glassy carbon electrode , 2007 .

[82]  Yunhui Yang,et al.  Hydrogen peroxide biosensor based on electrodeposition of zinc oxide nanoflowers onto carbon nanotubes film electrode , 2008 .

[83]  Kazuhiko Matsumoto,et al.  Calibration method for a carbon nanotube field-effect transistor biosensor , 2008, Nanotechnology.

[84]  T. Jovin,et al.  FRET imaging , 2003, Nature Biotechnology.

[85]  Yunqing Kang,et al.  Preparation and characterization of the biomineralized zinc oxide particles in spider silk peptides. , 2008, Journal of colloid and interface science.

[86]  Wei Zhang,et al.  Electrochemical sensing of DNA immobilization and hybridization based on carbon nanotubes/nano zinc oxide/chitosan composite film , 2008 .

[87]  Zhengtao Deng,et al.  Green and orange CdTe quantum dots as effective pH-sensitive fluorescent probes for dual simultaneous and independent detection of viruses. , 2007, The journal of physical chemistry. B.

[88]  Y. Chai,et al.  Direct electrocatalytic reduction of hydrogen peroxide based on Nafion and copper oxide nanoparticles modified Pt electrode , 2008 .

[89]  L. Whitman,et al.  Magnetic labeling, detection, and system integration. , 2008, Biosensors & bioelectronics.

[90]  Wen‐Chang Chen,et al.  A disposable glucose biosensor based on drop-coating of screen-printed carbon electrodes with magnetic nanoparticles , 2006 .

[91]  Ruo Yuan,et al.  Amperometric hydrogen peroxide biosensor based on the immobilization of HRP on nano-Au/Thi/poly (p-aminobenzene sulfonic acid)-modified glassy carbon electrode. , 2007, Journal of biochemical and biophysical methods.

[92]  F. Gao,et al.  Covalent attachment of quantum dot on carbon nanotubes , 2006 .

[93]  Jan Labuda,et al.  Disposable Electrochemical Biosensor with Multiwalled Carbon Nanotubes-Chitosan Composite Layer for the Detection of Deep DNA Damage , 2008, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[94]  Y. Kaneda,et al.  Magnetic nanoparticles with surface modification enhanced gene delivery of HVJ-E vector. , 2005, Biochemical and biophysical research communications.

[95]  Masato Saito,et al.  Nanomaterial-based electrochemical biosensors for medical applications , 2008 .

[96]  Jun-Jie Zhu,et al.  Horseradish peroxidase-functionalized gold nanoparticle label for amplified immunoanalysis based on gold nanoparticles/carbon nanotubes hybrids modified biosensor. , 2008, Biosensors & bioelectronics.

[97]  Do Kyung Kim,et al.  Antibiofouling polymer-coated superparamagnetic iron oxide nanoparticles as potential magnetic resonance contrast agents for in vivo cancer imaging. , 2006, Journal of the American Chemical Society.

[98]  Larry J. Kricka,et al.  Molecular and ionic recognition by biological systems , 1988 .

[99]  Do-Guwn Hwang,et al.  Detection of Magnetic Nanoparticles and Fe-hemoglobin inside Red Blood Cells by Using a Highly Sensitive Spin Valve Device , 2008 .

[100]  Tarl W. Prow,et al.  Nanoparticle-delivered biosensor for reactive oxygen species in diabetes , 2008, Vision Research.

[101]  S. Nie,et al.  Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules , 2001, Nature Biotechnology.

[102]  Duncan Graham,et al.  Sequence-specific DNA detection using high-affinity LNA-functionalized gold nanoparticles. , 2007, Small.

[103]  C. Ozkan,et al.  Dendrimer-modified magnetic nanoparticles enhance efficiency of gene delivery system. , 2007, Cancer research.

[104]  Keiichi Kaneto,et al.  Polypyrrole nanotube array sensor for enhanced adsorption of glucose oxidase in glucose biosensors. , 2007, Biosensors & bioelectronics.

[105]  Feng Gao,et al.  Hydrophilic high-luminescent magnetic nanocomposites , 2007, Nanotechnology.

[106]  B. Zeng,et al.  Development of amperometric glucose biosensor through immobilizing enzyme in a Pt nanoparticles/mesoporous carbon matrix. , 2008, Talanta.

[107]  Zhiwei Zhu,et al.  Structural and characteristic analysis of carbon nanotubes-ionic liquid gel biosensor , 2007 .

[108]  Jian Shen,et al.  A novel nitrite biosensor based on the direct electron transfer of hemoglobin immobilized on CdS hollow nanospheres. , 2008, Biosensors & bioelectronics.