Metallo-toeholds: controlling DNA strand displacement driven by Hg(II) ions.

Toehold-mediated strand displacement is a powerful tool that permits programmable control over DNA hybridization. Here, we developed a mechanism for strand displacement driven by Hg(2+) ions, in which the insertion of thymine-thymine mismatched base pairs on the toeholds provides additional control through variation of the concentration of Hg(2+) ions.

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