Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis
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Jerrold M. Ward | Frank J. Gonzalez | J. Ward | F. Gonzalez | G. Hayhurst | Gilles Lambert | G. Lambert | Graham P. Hayhurst | Ying-Hue Lee | Ying-Hue Lee
[1] J. Björkegren,et al. A Deficiency of Microsomal Triglyceride Transfer Protein Reduces Apolipoprotein B Secretion* , 2000, The Journal of Biological Chemistry.
[2] B. Viollet,et al. Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4 , 1997, Molecular and cellular biology.
[3] J. Chiang,et al. Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors. , 1998, Journal of lipid research.
[4] D. Leroith,et al. Normal growth and development in the absence of hepatic insulin-like growth factor I. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[5] D. Kardassis,et al. Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3. , 1992, The Journal of biological chemistry.
[6] A. Fukamizu,et al. Functional association between CBP and HNF4 in trans-activation. , 1997, Biochemical and biophysical research communications.
[7] J. Auwerx,et al. Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids. , 1994, The Journal of biological chemistry.
[8] M. Weiss,et al. Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells , 1997, Molecular and cellular biology.
[9] N. Daigle,et al. Hepatocyte Nuclear Factor 3β (Foxa2) Is Dispensable for Maintaining the Differentiated State of the Adult Hepatocyte , 2000, Molecular and Cellular Biology.
[10] C. Kahn,et al. Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes , 1999, Cell.
[11] D. Granner,et al. SRC-1 and GRIP1 Coactivate Transcription with Hepatocyte Nuclear Factor 4* , 1998, The Journal of Biological Chemistry.
[12] J. Peters,et al. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. , 1998, The Journal of biological chemistry.
[13] I. Talianidis,et al. Transcriptional regulation of the apolipoprotein A-IV gene involves synergism between a proximal orphan receptor response element and a distant enhancer located in the upstream promoter region of the apolipoprotein C-III gene. , 1994, Nucleic acids research.
[14] Frances M. Sladek,et al. Hepatocyte Nuclear Factor 4α , 2001 .
[15] S. Duncan,et al. Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha. , 2000, Genes & development.
[16] J. Darnell,et al. The expression pattern of a Drosophila homolog to the mouse transcription factor HNF‐4 suggests a determinative role in gut formation. , 1993, The EMBO journal.
[17] J. Bar-Tana,et al. Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α , 1998, Nature.
[18] J. Breslow,et al. Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice. , 1997, Journal of lipid research.
[19] S. Malik,et al. Control of Apolipoprotein AI Gene Expression through Synergistic Interactions between Hepatocyte Nuclear Factors 3 and 4* , 1996, The Journal of Biological Chemistry.
[20] P. Meier,et al. The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver* , 1998, The Journal of Biological Chemistry.
[21] Carl Wu. [14] Analysis of hypersensitive sites in chromatin , 1989 .
[22] M. Stoffel,et al. Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1) , 1996, Nature.
[23] F. Sladek,et al. The DNA Binding Domain of Hepatocyte Nuclear Factor 4 Mediates Cooperative, Specific Binding to DNA and Heterodimerization with the Retinoid X Receptor α* , 1997, The Journal of Biological Chemistry.
[24] D. Kardassis,et al. Cooperative Binding of Upstream Stimulatory Factor and Hepatic Nuclear Factor 4 Drives the Transcription of the Human Apolipoprotein A-II Gene* , 1999, The Journal of Biological Chemistry.
[25] J. Björkegren,et al. Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. , 1999, The Journal of clinical investigation.
[26] D. Kardassis,et al. Transactivation of the Human Apolipoprotein CII Promoter by Orphan and Ligand-dependent Nuclear Receptors , 1998, The Journal of Biological Chemistry.
[27] C. Glueck,et al. Effects of fenofibrate on lipids, lipoproteins, and apolipoproteins in 33 subjects with primary hypercholesterolemia. , 1987, Atherosclerosis.
[28] S M Grundy,et al. Dietary influences on serum lipids and lipoproteins. , 1990, Journal of lipid research.
[29] F. Alt,et al. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[30] J. Auwerx,et al. Alterations in thyroid status modulate apolipoprotein, hepatic triglyceride lipase, and low density lipoprotein receptor in rats. , 1990, Endocrinology.
[31] D. Kardassis,et al. A Short Proximal Promoter and the Distal Hepatic Control Region-1 (HCR-1) Contribute to the Liver Specificity of the Human Apolipoprotein C-II Gene , 1998, The Journal of Biological Chemistry.
[32] J. Peters,et al. Expression of Putative Fatty Acid Transporter Genes Are Regulated by Peroxisome Proliferator-activated Receptor α and γ Activators in a Tissue- and Inducer-specific Manner* , 1998, The Journal of Biological Chemistry.
[33] D. Moore,et al. Hepatocyte nuclear factor-4 activates medium chain acyl-CoA dehydrogenase gene transcription by interacting with a complex regulatory element. , 1993, The Journal of biological chemistry.
[34] J. Breslow,et al. Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[35] C. Wu. Analysis of hypersensitive sites in chromatin. , 1989, Methods in enzymology.
[36] P. Meier,et al. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver , 1997, Hepatology.
[37] Mark A. Magnuson,et al. Hepatocyte-Specific Mutation Establishes Retinoid X Receptor α as a Heterodimeric Integrator of Multiple Physiological Processes in the Liver , 2000, Molecular and Cellular Biology.
[38] C. Cladaras,et al. Functional Domains of the Nuclear Receptor Hepatocyte Nuclear Factor 4* , 1997, The Journal of Biological Chemistry.
[39] M. Bustin. Preparation and application of immunological probes for nucleosomes. , 1989, Methods in enzymology.
[40] A. Tedgui,et al. CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors. , 2000, Circulation.
[41] J. Auwerx,et al. Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. , 1995, The Journal of clinical investigation.
[42] Johnm . Taylor,et al. Structure of the Hepatic Control Region of the Human Apolipoprotein E/C-I Gene Locus (*) , 1995, The Journal of Biological Chemistry.
[43] J. Ward,et al. Regulation of the Liver Fatty Acid-binding Protein Gene by Hepatocyte Nuclear Factor 1α (HNF1α) ALTERATIONS IN FATTY ACID HOMEOSTASIS INHNF1α-DEFICIENT MICE , 2000 .
[44] G. Ginsburg,et al. Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells , 1992, Molecular and cellular biology.
[45] F. Sladek,et al. Orphan receptor HNF-4 and bZip protein C/EBP alpha bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription. , 1993, The Journal of biological chemistry.
[46] Gavin Kelsey,et al. Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis , 1994, Mechanisms of Development.
[47] S. Cereghini. Liver‐enriched transcription factors and hepatocyte differentiation , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[48] F. Gonzalez,et al. Targeted Disruption of the Microsomal Epoxide Hydrolase Gene , 1999, The Journal of Biological Chemistry.
[49] Masahiro Tohkin,et al. Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis , 2000, Cell.
[50] S. Karathanasis,et al. TFIIB-directed transcriptional activation by the orphan nuclear receptor hepatocyte nuclear factor 4 , 1996, Molecular and cellular biology.
[51] H. Brewer,et al. Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo. , 2000, Journal of lipid research.
[52] M. Krieger. Charting the fate of the "good cholesterol": identification and characterization of the high-density lipoprotein receptor SR-BI. , 1999, Annual review of biochemistry.
[53] C. Winrow,et al. Transactivation of the peroxisome proliferator-activated receptor is differentially modulated by hepatocyte nuclear factor-4. , 1994, Gene expression.
[54] I. Talianidis,et al. Acetylation regulates transcription factor activity at multiple levels. , 2000, Molecular cell.
[55] D. Moore,et al. A pleiotropic element in the medium-chain acyl coenzyme A dehydrogenase gene promoter mediates transcriptional regulation by multiple nuclear receptor transcription factors and defines novel receptor-DNA binding motifs , 1994, Molecular and cellular biology.
[56] J. Auwerx,et al. Expression of the Peroxisome Proliferator-activated Receptor Gene Is Stimulated by Stress and Follows a Diurnal Rhythm (*) , 1996, The Journal of Biological Chemistry.
[57] J. Darnell,et al. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. , 1990, Genes & development.
[58] G. Crabtree,et al. A transcriptional hierarchy involved in mammalian cell-type specification , 1992, Nature.
[59] M. Tulliez,et al. Expression of the L-type pyruvate kinase gene and the hepatocyte nuclear factor 4 transcription factor in exocrine and endocrine pancreas. , 1994, The Journal of biological chemistry.
[60] B. Chang,et al. Liver-specific Inactivation of the Abetalipoproteinemia Gene Completely Abrogates Very Low Density Lipoprotein/Low Density Lipoprotein Production in a Viable Conditional Knockout Mouse* , 1999, The Journal of Biological Chemistry.
[61] H. Jamil,et al. Transcriptional regulation of human and hamster microsomal triglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators. , 1994, The Journal of biological chemistry.
[62] Hao Li,et al. Targeted disruption of the apolipoprotein C-III gene in mice results in hypotriglyceridemia and protection from postprandial hypertriglyceridemia. , 1994, The Journal of biological chemistry.
[63] J. Chiang,et al. HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1). , 2000, Journal of lipid research.
[64] T. Hansen,et al. Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3) , 1996, Nature.
[65] P. A. Wood,et al. Transcriptional control of a nuclear gene encoding a mitochondrial fatty acid oxidation enzyme in transgenic mice: role for nuclear receptors in cardiac and brown adipose expression , 1996, Molecular and cellular biology.
[66] I. Talianidis,et al. Activation of CAAT Enhancer-binding Protein δ (C/EBPδ) by Interleukin-1 Negatively Influences Apolipoprotein C-III Expression* , 1997, The Journal of Biological Chemistry.
[67] J. Ward,et al. Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1alpha (HNF1alpha). Alterations in fatty acid homeostasis in HNF1alpha-deficient mice. , 2000, The Journal of biological chemistry.
[68] T. Osumi,et al. Functional interactions between nuclear receptors recognizing a common sequence element, the direct repeat motif spaced by one nucleotide (DR-1). , 1998, Journal of biochemistry.
[69] F. Hegardt,et al. The hepatocyte nuclear factor 4 (HNF-4) represses the mitochondrial HMG-CoA synthase gene. , 1998, Biochemical and biophysical research communications.
[70] K. Omori,et al. The apolipoprotein A-I/C-III/A-IV gene cluster: ApoC-III and ApoA-IV expression is regulated by two common enhancers. , 1997, Biochimica et biophysica acta.
[71] M. Rudnicki,et al. Simplified mammalian DNA isolation procedure. , 1991, Nucleic acids research.
[72] F. Sladek,et al. Modulation of Transcriptional Activation and Coactivator Interaction by a Splicing Variation in the F Domain of Nuclear Receptor Hepatocyte Nuclear Factor 4α1 , 1999, Molecular and Cellular Biology.
[73] M. Hadzopoulou-Cladaras,et al. CREB-binding Protein Is a Transcriptional Coactivator for Hepatocyte Nuclear Factor-4 and Enhances Apolipoprotein Gene Expression* , 1999, The Journal of Biological Chemistry.