Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis

[1]  E. Billington,et al.  Drug therapy for osteoporosis in older adults , 2022, The Lancet.

[2]  Li Duan,et al.  Systematic Analysis of mRNAs and ncRNAs in BMSCs of Senile Osteoporosis Patients , 2021, Frontiers in Genetics.

[3]  A. V. van Wijnen,et al.  Brd4 is required for chondrocyte differentiation and endochondral ossification. , 2021, Bone.

[4]  Yongzhi Cui,et al.  Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis , 2021, Redox biology.

[5]  Yan Liu,et al.  Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis , 2020, Stem cells international.

[6]  M. Longaker,et al.  Mechanisms of bone development and repair , 2020, Nature Reviews Molecular Cell Biology.

[7]  Q. Tong,et al.  Myeloma cells shift osteoblastogenesis to adipogenesis by inhibiting the ubiquitin ligase MURF1 in mesenchymal stem cells , 2020, Science Signaling.

[8]  Sangam Rajak,et al.  Selective dietary polyphenols induce differentiation of human osteoblasts by adiponectin receptor 1-mediated reprogramming of mitochondrial energy metabolism. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[9]  D. Shoback,et al.  New Frontiers in Osteoporosis Therapy. , 2020, Annual review of medicine.

[10]  Guowei Li,et al.  Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis , 2020, Frontiers in Endocrinology.

[11]  G. Stein,et al.  The epigenetic reader Brd4 is required for osteoblast differentiation , 2019, Journal of cellular physiology.

[12]  K. Sun,et al.  MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation , 2019, Nature Communications.

[13]  Jonghwan Kim,et al.  Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells , 2019, Nature Communications.

[14]  Jung-Min Kim,et al.  Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis , 2019, Nature Communications.

[15]  R. Braun,et al.  Identification of EOMES-expressing spermatogonial stem cells and their regulation by PLZF , 2019, eLife.

[16]  Anders K. Haakonsson,et al.  Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis , 2019, Nature Genetics.

[17]  Chad E. Grueter,et al.  Disruption of cardiac Med1 inhibits RNA polymerase II promoter occupancy and promotes chromatin remodeling. , 2019, American journal of physiology. Heart and circulatory physiology.

[18]  B. Berman,et al.  Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1 , 2018, Nucleic acids research.

[19]  K. Nakayama,et al.  Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16 , 2018, Nature Immunology.

[20]  M. Alivand,et al.  Gene expression of TWIST1 and ZBTB16 is regulated by methylation modifications during the osteoblastic differentiation of mesenchymal stem cells , 2018, Journal of cellular physiology.

[21]  Daniel S. Day,et al.  Coactivator condensation at super-enhancers links phase separation and gene control , 2018, Science.

[22]  A. Shilatifard,et al.  Born to run: control of transcription elongation by RNA polymerase II , 2018, Nature Reviews Molecular Cell Biology.

[23]  A. Shilatifard,et al.  Born to run: control of transcription elongation by RNA polymerase II , 2018, Nature Reviews Molecular Cell Biology.

[24]  Saptarsi M. Haldar,et al.  BET bromodomain proteins regulate enhancer function during adipogenesis , 2018, Proceedings of the National Academy of Sciences.

[25]  Yan Jin,et al.  Autophagy controls mesenchymal stem cell properties and senescence during bone aging , 2017, Aging cell.

[26]  G. Ronzitti,et al.  Emerging Issues in AAV-Mediated In Vivo Gene Therapy , 2017, Molecular therapy. Methods & clinical development.

[27]  Xueqian Wang,et al.  SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress , 2017, Cell Death and Differentiation.

[28]  L. S. Churchman,et al.  The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain , 2017, Nature Reviews Molecular Cell Biology.

[29]  Wenpeng Zhang,et al.  Differential long noncoding RNA/mRNA expression profiling and functional network analysis during osteogenic differentiation of human bone marrow mesenchymal stem cells , 2017, Stem Cell Research & Therapy.

[30]  S. Knapp,et al.  BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire , 2016, Nucleic acids research.

[31]  Y. Izumi,et al.  ZBTB16 as a Downstream Target Gene of Osterix Regulates Osteoblastogenesis of Human Multipotent Mesenchymal Stromal Cells , 2016, Journal of cellular biochemistry.

[32]  L. Hennighausen,et al.  Hierarchy within the mammary STAT5-driven Wap super-enhancer , 2016, Nature Genetics.

[33]  F. Bertucci,et al.  PLZF mutation alters mouse hematopoietic stem cell function and cell cycle progression. , 2016, Blood.

[34]  Irfan Khan,et al.  BET protein inhibitor JQ1 inhibits growth and modulates WNT signaling in mesenchymal stem cells , 2016, Stem Cell Research & Therapy.

[35]  Steven L Salzberg,et al.  HISAT: a fast spliced aligner with low memory requirements , 2015, Nature Methods.

[36]  J. Lieb,et al.  What are super-enhancers? , 2014, Nature Genetics.

[37]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[38]  A. Emili,et al.  RPRD1A and RPRD1B Are Human RNA Polymerase II C-Terminal Domain Scaffolds for Ser5 Dephosphorylation , 2014, Nature Structural &Molecular Biology.

[39]  Adelina Rogowska-Wrzesinska,et al.  Transcription factor cooperativity in early adipogenic hotspots and super-enhancers. , 2014, Cell reports.

[40]  Fidel Ramírez,et al.  deepTools: a flexible platform for exploring deep-sequencing data , 2014, Nucleic Acids Res..

[41]  M. Gosau,et al.  ZBTB16 induces osteogenic differentiation marker genes in dental follicle cells independent from RUNX2. , 2014, Journal of periodontology.

[42]  R. Young,et al.  Super-Enhancers in the Control of Cell Identity and Disease , 2013, Cell.

[43]  M. Blanchette,et al.  Nuclear import of RNA polymerase II is coupled with nucleocytoplasmic shuttling of the RNA polymerase II-associated protein 2 , 2013, Nucleic acids research.

[44]  David A. Orlando,et al.  Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers , 2013, Cell.

[45]  David A. Orlando,et al.  Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes , 2013, Cell.

[46]  John T. Lis,et al.  Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans , 2012, Nature Reviews Genetics.

[47]  B. N. Devaiah,et al.  BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain , 2012, Proceedings of the National Academy of Sciences.

[48]  Steven L Salzberg,et al.  Fast gapped-read alignment with Bowtie 2 , 2012, Nature Methods.

[49]  Tamás Kiss,et al.  Ser7 Phosphorylation of the CTD Recruits the RPAP2 Ser5 Phosphatase to snRNA Genes , 2012, Molecular cell.

[50]  Colin N. Dewey,et al.  RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome , 2011, BMC Bioinformatics.

[51]  R. Greil,et al.  PLZF/ZBTB16, a glucocorticoid response gene in acute lymphoblastic leukemia, interferes with glucocorticoid-induced apoptosis , 2010, Journal of Steroid Biochemistry and Molecular Biology.

[52]  C. Glass,et al.  Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. , 2010, Molecular cell.

[53]  Clifford A. Meyer,et al.  Model-based Analysis of ChIP-Seq (MACS) , 2008, Genome Biology.

[54]  Shona Murphy,et al.  Cracking the RNA polymerase II CTD code. , 2008, Trends in genetics : TIG.

[55]  Ruiqiang Li,et al.  SOAP: short oligonucleotide alignment program , 2008, Bioinform..

[56]  P. Pandolfi,et al.  Plzf regulates limb and axial skeletal patterning , 2000, Nature Genetics.

[57]  A. Zelent,et al.  Fusion between a novel Krüppel‐like zinc finger gene and the retinoic acid receptor‐alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. , 1993, The EMBO journal.