Biopolymer-based hydrogels for cartilage tissue engineering.

[1]  J. Mansour,et al.  Repair of large full-thickness articular cartilage defects with allograft articular chondrocytes embedded in a collagen gel. , 1998, Tissue engineering.

[2]  Kinam Park,et al.  Environment-sensitive hydrogels for drug delivery , 2001 .

[3]  Farshid Guilak,et al.  Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. , 2004, Biomaterials.

[4]  J. Burdick,et al.  Macromer density influences mesenchymal stem cell chondrogenesis and maturation in photocrosslinked hyaluronic acid hydrogels. , 2009, Osteoarthritis and cartilage.

[5]  E. Morris,et al.  Inhibition of interleukin 1-mediated proteoglycan degradation in bovine articular cartilage explants by addition of sodium hyaluronate. , 1992, American journal of veterinary research.

[6]  Jianwei Wang,et al.  Growth factor regulation of human growth plate chondrocyte proliferation in vitro. , 2004, Biochemical and biophysical research communications.

[7]  Zheng Cui,et al.  Effect of Extracellular pH on Matrix Synthesis by Chondrocytes in 3D Agarose Gel , 2007, Biotechnology progress.

[8]  E. Thonar,et al.  Protective effect of exogenous chondroitin 4,6-sulfate in the acute degradation of articular cartilage in the rabbit. , 1998, Osteoarthritis and cartilage.

[9]  Eben Alsberg,et al.  Degradation of Partially Oxidized Alginate and Its Potential Application for Tissue Engineering , 2001, Biotechnology progress.

[10]  W. Bonner,et al.  Changes in the lipids of human articular cartilage with age. , 1975, Arthritis and rheumatism.

[11]  F. Greco,et al.  N,N-dicarboxymethyl chitosan as delivery agent for bone morphogenetic protein in the repair of articular cartilage , 2006, Medical and Biological Engineering and Computing.

[12]  J. Thomson,et al.  Embryonic stem cell lines derived from human blastocysts. , 1998, Science.

[13]  Glenn D Prestwich,et al.  In situ crosslinkable hyaluronan hydrogels for tissue engineering. , 2004, Biomaterials.

[14]  G. Wnek,et al.  Encyclopedia of biomaterials and biomedical engineering , 2008 .

[15]  D J Mooney,et al.  Development of biocompatible synthetic extracellular matrices for tissue engineering. , 1998, Trends in biotechnology.

[16]  D. Saris,et al.  Joint homeostasis. The discrepancy between old and fresh defects in cartilage repair. , 2003, The Journal of bone and joint surgery. British volume.

[17]  G. Naughton,et al.  Evaluation of matrix scaffolds for tissue engineering of articular cartilage grafts. , 1997, Journal of biomedical materials research.

[18]  S. Kim,et al.  Injectable cartilage: using alginate and human chondrocytes. , 2009, Archives of facial plastic surgery.

[19]  T. Holmes,et al.  Novel peptide-based biomaterial scaffolds for tissue engineering. , 2002, Trends in biotechnology.

[20]  P. Manson,et al.  In Vivo Chondrogenesis of Mesenchymal Stem Cells in a Photopolymerized Hydrogel , 2007, Plastic and reconstructive surgery.

[21]  N. Kubota,et al.  A simple preparation of half N-acetylated chitosan highly soluble in water and aqueous organic solvents. , 2000, Carbohydrate research.

[22]  S. Oh,et al.  Fabrication and characterization of porous alginate/polyvinyl alcohol hybrid scaffolds for 3D cell culture , 2005, Journal of biomaterials science. Polymer edition.

[23]  Scott Hollister,et al.  Tissue-engineered cartilage constructs using composite hyaluronic acid/collagen I hydrogels and designed poly(propylene fumarate) scaffolds. , 2007, Tissue engineering.

[24]  S. O’Driscoll Preclinical cartilage repair: current status and future perspectives. , 2001, Clinical orthopaedics and related research.

[25]  Freddie H. Fu,et al.  GAG-augmented polysaccharide hydrogel: a novel biocompatible and biodegradable material to support chondrogenesis. , 2000, Journal of biomedical materials research.

[26]  D. Saris,et al.  The chondrogenic potential of periosteum decreases with age , 2001, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[27]  T. Hanawa,et al.  New oral dosage form for elderly patients: preparation and characterization of silk fibroin gel. , 1995, Chemical & pharmaceutical bulletin.

[28]  Su-Hyang Kim,et al.  Chondrogenic differentiation of human mesenchymal stem cells using a thermosensitive poly(N-isopropylacrylamide) and water-soluble chitosan copolymer. , 2004, Biomaterials.

[29]  Hwa-Chang Liu,et al.  Gelatin-chondroitin-hyaluronan tri-copolymer scaffold for cartilage tissue engineering. , 2003, Biomaterials.

[30]  E. Kastenbauer,et al.  Cartilage tissue engineering with novel nonwoven structured biomaterial based on hyaluronic acid benzyl ester. , 1998, Journal of biomedical materials research.

[31]  S. Lynch,et al.  A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair. , 2006, Osteoarthritis and cartilage.

[32]  M D McKee,et al.  Tissue engineering of cartilage using an injectable and adhesive chitosan-based cell-delivery vehicle. , 2005, Osteoarthritis and cartilage.

[33]  W. B. van den Berg,et al.  Linkage of chondroitin-sulfate to type I collagen scaffolds stimulates the bioactivity of seeded chondrocytes in vitro. , 2001, Biomaterials.

[34]  E. Hunziker,et al.  Development of mechanically stable alginate/chondrocyte constructs: effects of guluronic acid content and matrix synthesis , 2001, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[35]  Gregory M. Williams,et al.  Cell density alters matrix accumulation in two distinct fractions and the mechanical integrity of alginate-chondrocyte constructs. , 2005, Acta biomaterialia.

[36]  J. Ringe,et al.  In Vitro Expression of Cartilage-Specific Markers by Chondrocytes on a Biocompatible Hydrogel: Implications for Engineering Cartilage Tissue , 2001, Cell transplantation.

[37]  K. Ikeuchi,et al.  Frictional properties of regenerated cartilage in vitro. , 2006, Journal of biomechanics.

[38]  W. B. van den Berg,et al.  Chondrocyte behaviour within different types of collagen gel in vitro. , 1995, Biomaterials.

[39]  M. Lammi Cellular Signaling in Cartilage Tissue Engineering , 2007 .

[40]  P. Venge,et al.  Regulation of granulocyte function by hyaluronic acid. In vitro and in vivo effects on phagocytosis, locomotion, and metabolism. , 1980, The Journal of clinical investigation.

[41]  R. Tuan,et al.  Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture. , 2006, Osteoarthritis and cartilage.

[42]  Dietmar W. Hutmacher,et al.  Long-term effects of hydrogel properties on human chondrocyte behavior , 2010 .

[43]  Jiake Xu,et al.  Fibrin sealant promotes migration and proliferation of human articular chondrocytes: possible involvement of thrombin and protease-activated receptors. , 2006, International journal of molecular medicine.

[44]  J. Jespersen,et al.  Fibrin Clot Formation and Lysis: Basic Mechanisms , 2000, Seminars in thrombosis and hemostasis.

[45]  C B Sledge,et al.  Canine chondrocytes seeded in type I and type II collagen implants investigated in vitro. , 1997, Journal of biomedical materials research.

[46]  A. Jayakrishnan,et al.  Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds. , 2005, Biomaterials.

[47]  K. Arden,et al.  Expression of the human chondrocyte phenotype in vitro , 1989, In Vitro Cellular & Developmental Biology.

[48]  Kell Mortensen,et al.  Structural study on the micelle formation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer in aqueous solution , 1993 .

[49]  Jason A Burdick,et al.  Engineering cartilage tissue. , 2008, Advanced drug delivery reviews.

[50]  R Langer,et al.  Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers. , 1993, Journal of biomedical materials research.

[51]  J. Vacanti,et al.  Joint Resurfacing with Cartilage Grown in Situ from Cell-Polymer Structures , 1994, The American journal of sports medicine.

[52]  A. Grodzinsky,et al.  Chondrocytes in agarose culture synthesize a mechanically functional extracellular matrix , 1992, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[53]  Guoping Chen,et al.  Tissue engineering of cartilage using a hybrid scaffold of synthetic polymer and collagen. , 2004, Tissue engineering.

[54]  S. Nehrer,et al.  Three-year clinical outcome after chondrocyte transplantation using a hyaluronan matrix for cartilage repair. , 2006, European journal of radiology.

[55]  M. Ostensen,et al.  Responses of normal and rheumatic human articular chondrocytes cultured under various experimental conditions in agarose. , 1991, Scandinavian journal of rheumatology.

[56]  T. Ushida,et al.  Hybrid Biomaterials for Tissue Engineering: A Preparative Method for PLA or PLGA–Collagen Hybrid Sponges , 2000 .

[57]  J. Leroux,et al.  Novel injectable neutral solutions of chitosan form biodegradable gels in situ. , 2000, Biomaterials.

[58]  P. Buma,et al.  Culture of chondrocytes in alginate and collagen carrier gels. , 1995, Acta orthopaedica Scandinavica.

[59]  A. Vetere,et al.  The aggregation of pig articular chondrocyte and synthesis of extracellular matrix by a lactose-modified chitosan. , 2005, Biomaterials.

[60]  Mark A Randolph,et al.  Photochemically cross-linked collagen gels as three-dimensional scaffolds for tissue engineering. , 2007, Tissue engineering.

[61]  Shyni Varghese,et al.  Chondroitin sulfate based niches for chondrogenic differentiation of mesenchymal stem cells. , 2008, Matrix biology : journal of the International Society for Matrix Biology.

[62]  D. Bader,et al.  Passage in monolayer influences the response of chondrocytes to dynamic compression. , 2004, Biorheology.

[63]  P. Gong,et al.  Ectopic osteogenesis and chondrogenesis of bone marrow stromal stem cells in alginate system , 2007, Cell biology international.

[64]  J. Yoon,et al.  Fabrication of Hyaluronic Acid Hydrogel Beads for Cell Encapsulation , 2006, Biotechnology progress.

[65]  C B Sledge,et al.  Matrix collagen type and pore size influence behaviour of seeded canine chondrocytes. , 1997, Biomaterials.

[66]  D. Kaplan,et al.  In vivo degradation of three-dimensional silk fibroin scaffolds. , 2008, Biomaterials.

[67]  G. Homandberg,et al.  Hyaluronic acid suppresses fibronectin fragment mediated cartilage chondrolysis: I. In vitro. , 1997, Osteoarthritis and cartilage.

[68]  T. Ando,et al.  In vitro effects of hyaluronan on prostaglandin E2 induction by interleukin-1 in rabbit articular chondrocytes , 2005, Agents and Actions.

[69]  Hyun-chul Lee,et al.  Preparation of semi-interpenetrating polymer networks composed of silk fibroin and poloxamer macromer. , 2004, International journal of biological macromolecules.

[70]  Christoph Gaissmaier,et al.  Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads. , 2004, Osteoarthritis and cartilage.

[71]  P. Roughley Age-associated changes in cartilage matrix: implications for tissue repair. , 2001, Clinical orthopaedics and related research.

[72]  A. Mikos,et al.  Injectable biodegradable materials for orthopedic tissue engineering. , 2000, Biomaterials.

[73]  E. Thonar,et al.  Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. , 1998, Osteoarthritis and cartilage.

[74]  B. Strates,et al.  Chemically modified collagen: a natural biomaterial for tissue replacement. , 1987, Journal of biomedical materials research.

[75]  C. B. Machado,et al.  The effect of a chitosan–gelatin matrix and dexamethasone on the behavior of rabbit mesenchymal stem cells , 2006, Biomedical materials.

[76]  G. V. van Osch,et al.  A new in vivo model for testing cartilage grafts and biomaterials: the 'rabbit pinna punch-hole' model. , 2001, Biomaterials.

[77]  E. Hunziker,et al.  Biologic repair of articular cartilage. Defect models in experimental animals and matrix requirements. , 1999, Clinical orthopaedics and related research.

[78]  T. Matsuda,et al.  Tissue-engineered cartilage using an injectable and in situ gelable thermoresponsive gelatin: fabrication and in vitro performance. , 2003, Tissue engineering.

[79]  G. Daculsi,et al.  A silanized hydroxypropyl methylcellulose hydrogel for the three-dimensional culture of chondrocytes. , 2005, Biomaterials.

[80]  S. Madorsky,et al.  Secondary rhinoplasty in nasal deformity associated with the unilateral cleft lip. , 1999, Archives of facial plastic surgery.

[81]  L. Punzi,et al.  The influence of intra-articular hyaluronic acid on PGE2 and cAMP of synovial fluid. , 1989, Clinical and experimental rheumatology.

[82]  L. Bonassar,et al.  Effect of substrate mechanics on chondrocyte adhesion to modified alginate surfaces. , 2004, Archives of biochemistry and biophysics.

[83]  K. Marra,et al.  Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering. , 2009, Biomaterials.

[84]  N. Peppas,et al.  Hydrogels in Pharmaceutical Formulations , 1999 .

[85]  L Sedel,et al.  Effects of chitosan on rat knee cartilages. , 1999, Biomaterials.

[86]  Andrés J. García,et al.  Inhibition of in vitro chondrogenesis in RGD-modified three-dimensional alginate gels. , 2007, Biomaterials.

[87]  Peter M Jakob,et al.  Iron oxide labelling of human mesenchymal stem cells in collagen hydrogels for articular cartilage repair. , 2008, Biomaterials.

[88]  M. Fussenegger,et al.  Stabilization of fibrin-chondrocyte constructs for cartilage reconstruction. , 1999, Annals of plastic surgery.

[89]  H. Helminen,et al.  Effects of cyclic hydrostatic pressure on proteoglycan synthesis in cultured chondrocytes and articular cartilage explants. , 1993, Archives of biochemistry and biophysics.

[90]  O. Damour,et al.  Chitosan-chondroitin sulfate and chitosan-hyaluronate polyelectrolyte complexes: biological properties. , 1998, Biomaterials.

[91]  Shyni Varghese,et al.  Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration. , 2007, Nature materials.

[92]  Lori A. Setton,et al.  Photocrosslinkable Hyaluronan as a Scaffold for Articular Cartilage Repair , 2004, Annals of Biomedical Engineering.

[93]  G. Lisignoli,et al.  Human chondrocytes and mesenchymal stem cells grown onto engineered scaffold. , 2006, Biorheology.

[94]  Xinqiao Jia,et al.  Hierarchically structured, hyaluronic acid-based hydrogel matrices via the covalent integration of microgels into macroscopic networks. , 2010, Soft matter.

[95]  S. Hsu,et al.  Evaluation of chitosan-alginate-hyaluronate complexes modified by an RGD-containing protein as tissue-engineering scaffolds for cartilage regeneration. , 2004, Artificial organs.

[96]  Lars Engebretsen,et al.  Clinical application of scaffolds for cartilage tissue engineering , 2008, Knee Surgery, Sports Traumatology, Arthroscopy.

[97]  Keun-Hong Park,et al.  Synergistic effect of TGFbeta-3 on chondrogenic differentiation of rabbit chondrocytes in thermo-reversible hydrogel constructs blended with hyaluronic acid by in vivo test. , 2007, Journal of biotechnology.

[98]  Lisa M. McDevitt Etiology and impact of cytomegalovirus disease on solid organ transplant recipients. , 2006, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[99]  Jun Wang,et al.  Photocrosslinkable polysaccharides based on chondroitin sulfate. , 2004, Journal of biomedical materials research. Part A.

[100]  Y Ikada,et al.  Effect of basic fibroblast growth factor on cartilage regeneration in chondrocyte-seeded collage scaffold ns , 2003 .

[101]  L. Lippiello,et al.  Glucosamine and chondroitin sulfate: biological response modifiers of chondrocytes under simulated conditions of joint stress. , 2003, Osteoarthritis and cartilage.

[102]  Elizabeth G Loboa,et al.  Differential effects on messenger ribonucleic acid expression by bone marrow-derived human mesenchymal stem cells seeded in agarose constructs due to ramped and steady applications of cyclic hydrostatic pressure. , 2007, Tissue engineering.

[103]  D. W. Jackson,et al.  Cartilage Substitutes: Overview of Basic Science and Treatment Options , 2001, The Journal of the American Academy of Orthopaedic Surgeons.

[104]  K. Shakesheff,et al.  Injectable scaffolds for tissue regeneration , 2004 .

[105]  W. Hao,et al.  A novel injectable scaffold for cartilage tissue engineering using adipose‐derived adult stem cells , 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[106]  B. Amsden,et al.  Methacrylated glycol chitosan as a photopolymerizable biomaterial. , 2007, Biomacromolecules.

[107]  G. Bentley,et al.  Effect of Normal Synovial Fluid on the Metabolism of Articular Chondrocytes In Vitro , 1997, Clinical orthopaedics and related research.

[108]  R. Loeser,et al.  The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes. , 2003, Arthritis and rheumatism.

[109]  Gordana Vunjak-Novakovic,et al.  Engineering cartilage‐like tissue using human mesenchymal stem cells and silk protein scaffolds , 2004, Biotechnology and bioengineering.

[110]  Gabriela A Silva,et al.  Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. , 2007, Advanced drug delivery reviews.

[111]  K. Hirabayashi,et al.  Mechanism of the gelation of fibroin solution , 1993 .

[112]  R E Guldberg,et al.  Variations in matrix composition and GAG fine structure among scaffolds for cartilage tissue engineering. , 2005, Osteoarthritis and cartilage.

[113]  L. Galois,et al.  Bovine chondrocyte behaviour in three-dimensional type I collagen gel in terms of gel contraction, proliferation and gene expression. , 2006, Biomaterials.

[114]  V. Normand,et al.  New insight into agarose gel mechanical properties. , 2000, Biomacromolecules.

[115]  J. Elisseeff,et al.  In vitro prefabrication of human cartilage shapes using fibrin glue and human chondrocytes. , 1998, Annals of Plastic Surgery.

[116]  Ung-Jin Kim,et al.  Structure and properties of silk hydrogels. , 2004, Biomacromolecules.

[117]  R. Stockwell Lipid in the Matrix of Ageing Articular Cartilage , 1965, Nature.

[118]  T. Scheper,et al.  Application of collagen matrices for cartilage tissue engineering. , 2006, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[119]  R. Stockwell,et al.  Observations on the acid glycosaminoglycan (mucopolysaccharide) content of the matrix of aging cartilage. , 1965, Annals of the rheumatic diseases.

[120]  D. Aeschlimann,et al.  New strategy for chemical modification of hyaluronic acid: preparation of functionalized derivatives and their use in the formation of novel biocompatible hydrogels. , 1999, Journal of biomedical materials research.

[121]  Changyou Gao,et al.  Gelatin hydrogel prepared by photo-initiated polymerization and loaded with TGF-beta1 for cartilage tissue engineering. , 2009, Macromolecular bioscience.

[122]  Jiyoung M Dang,et al.  Temperature-responsive hydroxybutyl chitosan for the culture of mesenchymal stem cells and intervertebral disk cells. , 2006, Biomaterials.

[123]  G. Ateshian,et al.  Dynamic deformational loading results in selective application of mechanical stimulation in a layered, tissue-engineered cartilage construct. , 2006, Biorheology.

[124]  F. Mallein-Gerin,et al.  Comparative phenotypic analysis of articular chondrocytes cultured within type I or type II collagen scaffolds. , 2009, Tissue engineering. Part A.

[125]  Makarand V Risbud,et al.  Chitosan: a versatile biopolymer for orthopaedic tissue-engineering. , 2005, Biomaterials.

[126]  Yi Yan Yang,et al.  Injectable biodegradable hydrogels composed of hyaluronic acid-tyramine conjugates for drug delivery and tissue engineering. , 2005, Chemical communications.

[127]  Ick Chan Kwon,et al.  Effects of the controlled-released TGF-beta 1 from chitosan microspheres on chondrocytes cultured in a collagen/chitosan/glycosaminoglycan scaffold. , 2004, Biomaterials.

[128]  Jui-Sheng Sun,et al.  Fibrin glue mixed with gelatin/hyaluronic acid/chondroitin-6-sulfate tri-copolymer for articular cartilage tissue engineering: the results of real-time polymerase chain reaction. , 2007, Journal of biomedical materials research. Part A.

[129]  J. Suh,et al.  Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. , 2000, Biomaterials.

[130]  Y. Kato,et al.  Effects of hyaluronic acid on the release of proteoglycan from the cell matrix in rabbit chondrocyte cultures in the presence and absence of cytokines. , 1993, Arthritis and rheumatism.

[131]  W. B. van den Berg,et al.  Chondrocyte-seeded hydroxyapatite for repair of large articular cartilage defects. A pilot study in the goat. , 1998, Biomaterials.

[132]  Ivan Martin,et al.  Age related changes in human articular chondrocyte yield, proliferation and post-expansion chondrogenic capacity. , 2004, Osteoarthritis and cartilage.

[133]  M. Pittenger,et al.  Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.

[134]  Christopher J Hunter,et al.  Dynamic compression of chondrocyte-seeded fibrin gels: effects on matrix accumulation and mechanical stiffness. , 2004, Osteoarthritis and cartilage.

[135]  Ann L. Johnson,et al.  Chitosan scaffolds: interconnective pore size and cartilage engineering. , 2006, Acta biomaterialia.

[136]  K. Na,et al.  Combination material delivery of dexamethasone and growth factor in hydrogel blended with hyaluronic acid constructs for neocartilage formation. , 2007, Journal of biomedical materials research. Part A.

[137]  Yi Hong,et al.  Covalently crosslinked chitosan hydrogel: properties of in vitro degradation and chondrocyte encapsulation. , 2007, Acta biomaterialia.

[138]  A. Hall,et al.  Differential effects of hydrostatic pressure on cation transport pathways of isolated articular chondrocytes , 1999, Journal of cellular physiology.

[139]  H. Cheung,et al.  Chondrogenesis of human bone marrow-derived mesenchymal stem cells in agarose culture. , 2004, The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology.

[140]  L. Bonassar,et al.  Review of injectable cartilage engineering using fibrin gel in mice and swine models. , 2006, Tissue engineering.

[141]  Ta-Jen Huang,et al.  Effect of pore size on ECM secretion and cell growth in gelatin scaffold for articular cartilage tissue engineering. , 2009, Acta biomaterialia.

[142]  H. Sashiwa,et al.  Chemical modification of chitin and chitosan 2: preparation and water soluble property of N-acylated or N-alkylated partially deacetylated chitins , 1999 .

[143]  C B Sledge,et al.  Chondrocyte-seeded collagen matrices implanted in a chondral defect in a canine model. , 1998, Biomaterials.

[144]  E. Menzel,et al.  Hyaluronidase and its substrate hyaluronan: biochemistry, biological activities and therapeutic uses. , 1998, Cancer letters.

[145]  C A van Blitterswijk,et al.  Synthesis and characterization of hyaluronic acid-poly(ethylene glycol) hydrogels via Michael addition: An injectable biomaterial for cartilage repair. , 2010, Acta biomaterialia.

[146]  E. Thorne The Shortage in Market‐Inalienable Human Organs: A Consideration of “Nonmarket” Failures , 1998 .

[147]  S. Messier,et al.  Osteoarthritis of the knee and associated factors of age and obesity: effects on gait. , 1994, Medicine and science in sports and exercise.

[148]  R. Guldberg,et al.  Hydrogel effects on bone marrow stromal cell response to chondrogenic growth factors. , 2007, Biomaterials.

[149]  L. Bian,et al.  Influence of chondroitin sulfate on the biochemical, mechanical and frictional properties of cartilage explants in long-term culture. , 2009, Journal of biomechanics.

[150]  J. Wang,et al.  Ectopic neocartilage formation from predifferentiated human adipose derived stem cells induced by adenoviral-mediated transfer of hTGF beta2. , 2007, Biomaterials.

[151]  H. Adler,et al.  Evaluation of oligo(ethylene glycol) dimethacrylates effects on the properties of new biodegradable bone cement compositions. , 2005, Macromolecular bioscience.

[152]  Ta-Jen Huang,et al.  Genipin-crosslinked gelatin scaffolds for articular cartilage tissue engineering with a novel crosslinking method , 2008 .

[153]  F. Guilak,et al.  Effects of Transforming Growth Factor β1 and Dexamethasone on the Growth and Chondrogenic Differentiation of Adipose-Derived Stromal Cells , 2003 .

[154]  Y. Ohya,et al.  Possibility of application of quaternary chitosan having pendant galactose residues as gene delivery tool , 1996 .

[155]  Jason A Burdick,et al.  Hydrolytically degradable hyaluronic acid hydrogels with controlled temporal structures. , 2008, Biomacromolecules.

[156]  Pieter Buma,et al.  Cross-linked type I and type II collagenous matrices for the repair of full-thickness articular cartilage defects--a study in rabbits. , 2003, Biomaterials.

[157]  G A Ateshian,et al.  Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. , 2000, Journal of biomechanical engineering.

[158]  Robert Langer,et al.  Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks. , 2005, Biomacromolecules.

[159]  D Mainard,et al.  Cartilage repair using new polysaccharidic biomaterials: macroscopic, histological and biochemical approaches in a rat model of cartilage defect. , 2003, Osteoarthritis and cartilage.

[160]  J. Steinmeyer,et al.  Intermittent cyclic loading of cartilage explants modulates fibronectin metabolism. , 1997, Osteoarthritis and cartilage.

[161]  E B Hunziker,et al.  Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture. , 1995, Journal of cell science.

[162]  Tsui-Chu Yang,et al.  Preparation, water solubility and rheological property of the N-alkylated mono or disaccharide chitosan derivatives , 2002 .

[163]  Zsuzsanna Bereczky,et al.  Fibrin Stabilization (Factor XIII), Fibrin Structure and Thrombosis , 2003, Pathophysiology of Haemostasis and Thrombosis.

[164]  Eben Alsberg,et al.  Photocrosslinked alginate hydrogels with tunable biodegradation rates and mechanical properties. , 2009, Biomaterials.

[165]  R. Turner,et al.  Clinical manifestations in HLA-B27-positive patients. , 1987 .

[166]  David L Kaplan,et al.  Silk hydrogel for cartilage tissue engineering. , 2010, Journal of biomedical materials research. Part B, Applied biomaterials.

[167]  Ling Qin,et al.  Cartilage regeneration using mesenchymal stem cells and a PLGA-gelatin/chondroitin/hyaluronate hybrid scaffold. , 2006, Biomaterials.

[168]  Stephanie J Bryant,et al.  Incorporation of tissue-specific molecules alters chondrocyte metabolism and gene expression in photocrosslinked hydrogels. , 2005, Acta biomaterialia.

[169]  M. Fussenegger,et al.  Stabilized Autologous Fibrin-Chondrocyte Constructs for Cartilage Repair in Vivo , 2003, Annals of plastic surgery.

[170]  H. G. Schild Poly(N-isopropylacrylamide): experiment, theory and application , 1992 .

[171]  T. Ochi,et al.  Articular cartilage repair. Rabbit experiments with a collagen gel-biomatrix and chondrocytes cultured in it. , 1998, Acta orthopaedica Scandinavica.

[172]  F. Tanfani,et al.  N-(carboxymethylidene)chitosans and N-(carboxymethyl)chitosans: Novel chelating polyampholytes obtained from chitosan glyoxylate , 1982 .

[173]  P. Marchal,et al.  New physically and chemically crosslinked hyaluronate (HA)-based hydrogels for cartilage repair. , 2006, Journal of biomedical materials research. Part A.

[174]  Gerard A Ateshian,et al.  Synergistic action of growth factors and dynamic loading for articular cartilage tissue engineering. , 2003, Tissue engineering.

[175]  A. Braccini,et al.  Dynamic compression of cartilage constructs engineered from expanded human articular chondrocytes. , 2003, Biochemical and biophysical research communications.

[176]  Makarand V Risbud,et al.  Tissue engineering: advances in in vitro cartilage generation. , 2002, Trends in biotechnology.

[177]  T. Fujinaga,et al.  Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells (MSCs) in different hydrogels: Influence of collagen type II extracellular matrix on MSC chondrogenesis , 2006, Biotechnology and bioengineering.

[178]  G. Meachim Age changes in articular cartilage. , 2001, Clinical orthopaedics and related research.

[179]  J. Feijen,et al.  Injectable chitosan-based hydrogels for cartilage tissue engineering. , 2009, Biomaterials.

[180]  R M Shelton,et al.  Adhesion and growth of bone marrow stromal cells on modified alginate hydrogels. , 2004, Tissue engineering.

[181]  A Montembault,et al.  A material decoy of biological media based on chitosan physical hydrogels: application to cartilage tissue engineering. , 2006, Biochimie.

[182]  W. Dhert,et al.  Effects of immobilization and continuous passive motion on postoperative muscle atrophy in mature rabbits. , 1988, Canadian journal of surgery. Journal canadien de chirurgie.

[183]  Wai-Hee Lo,et al.  Chondrogenesis of human mesenchymal stem cells encapsulated in alginate beads. , 2003, Journal of biomedical materials research. Part A.

[184]  Ung-Jin Kim,et al.  In vitro cartilage tissue engineering with 3D porous aqueous-derived silk scaffolds and mesenchymal stem cells. , 2005, Biomaterials.

[185]  C. Ohlsson,et al.  Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. , 1994, The New England journal of medicine.

[186]  A. Hollander,et al.  Localization of type VI collagen in tissue-engineered cartilage on polymer scaffolds. , 2006, Tissue engineering.

[187]  U. Weis-Fogh,et al.  Important factors influencing the strength of autologous fibrin glue; the fibrin concentration and reaction time--comparison of strength with commercial fibrin glue. , 1994, European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.

[188]  Hinrich Wiese,et al.  Long-term stable fibrin gels for cartilage engineering. , 2007, Biomaterials.

[189]  G. Finkenzeller,et al.  Mesenchymal stem cells maintain TGF-beta-mediated chondrogenic phenotype in alginate bead culture. , 2006, Tissue engineering.

[190]  Mauro Alini,et al.  Fibrin-polyurethane composites for articular cartilage tissue engineering: a preliminary analysis. , 2005, Tissue engineering.

[191]  A. Grodzinsky,et al.  Biosynthetic response of cartilage explants to dynamic compression , 1989, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[192]  T. Aigner,et al.  Synergistic effect of IGF-1 and OP-1 on matrix formation by normal and OA chondrocytes cultured in alginate beads. , 2007, Osteoarthritis and cartilage.

[193]  D. Kohane,et al.  HYDROGELS IN DRUG DELIVERY: PROGRESS AND CHALLENGES , 2008 .

[194]  B. Cho,et al.  Different Effects of PLGA and Chitosan Scaffolds on Human Cartilage Tissue Engineering , 2007, The Journal of craniofacial surgery.

[195]  D L Bader,et al.  Response of chondrocyte subpopulations cultured within unloaded and loaded agarose , 1998, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[196]  D. Mooney,et al.  Hydrogels for tissue engineering. , 2001, Chemical Reviews.

[197]  C A van Blitterswijk,et al.  Enzymatically-crosslinked injectable hydrogels based on biomimetic dextran-hyaluronic acid conjugates for cartilage tissue engineering. , 2010, Biomaterials.

[198]  A H Huang,et al.  Tensile properties of engineered cartilage formed from chondrocyte- and MSC-laden hydrogels. , 2008, Osteoarthritis and cartilage.

[199]  Gordana Vunjak-Novakovic,et al.  Differential effects of growth factors on tissue-engineered cartilage. , 2002, Tissue engineering.

[200]  Gordana Vunjak-Novakovic,et al.  Bone Tissue Engineering Using Human Mesenchymal Stem Cells: Effects of Scaffold Material and Medium Flow , 2004, Annals of Biomedical Engineering.

[201]  G G Reinholz,et al.  Animal models for cartilage reconstruction. , 2004, Biomaterials.

[202]  D. Mooney,et al.  Shear-reversibly crosslinked alginate hydrogels for tissue engineering. , 2009, Macromolecular bioscience.

[203]  L Sedel,et al.  Engineering of implantable cartilaginous structures from bone marrow-derived mesenchymal stem cells. , 2007, Tissue engineering.

[204]  J. Caron,et al.  Glucosamine and chondroitin sulfate regulate gene expression and synthesis of nitric oxide and prostaglandin E(2) in articular cartilage explants. , 2005, Osteoarthritis and cartilage.

[205]  J. Forrester,et al.  Inhibition of phagocytosis by high molecular weight hyaluronate. , 1980, Immunology.

[206]  Mutsumi Takagi,et al.  Effect of chondroitin sulfate and hyaluronic acid on gene expression in a three-dimensional culture of chondrocytes. , 2005, Journal of bioscience and bioengineering.

[207]  W. B. van den Berg,et al.  Stimulation of articular cartilage repair in established arthritis by local administration of transforming growth factor-beta into murine knee joints. , 1998, Laboratory investigation; a journal of technical methods and pathology.

[208]  T Ochi,et al.  Repair of rabbit articular surfaces with allograft chondrocytes embedded in collagen gel. , 1989, The Journal of bone and joint surgery. British volume.

[209]  Shinji Sakai,et al.  Synthesis of enzymatically-gellable carboxymethylcellulose for biomedical applications. , 2007, Journal of bioscience and bioengineering.

[210]  K. Yao,et al.  Biomimetic surface modification of poly(L-lactic acid) with chitosan and its effects on articular chondrocytes in vitro. , 2003, Biomaterials.

[211]  D. Kaplan,et al.  Biopolymer-based biomaterials as scaffolds for tissue engineering. , 2006, Advances in biochemical engineering/biotechnology.