Indirubin-3′-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway

[1]  M. Phillip,et al.  Short and tall stature: a new paradigm emerges , 2015, Nature Reviews Endocrinology.

[2]  Kang-Yell Choi,et al.  Indirubin‐3′‐Oxime Reverses Bone Loss in Ovariectomized and Hindlimb‐Unloaded Mice Via Activation of the Wnt/β‐Catenin Signaling , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[3]  Lei Zhang,et al.  Inactivation of glycogen synthase kinase-3β up-regulates β-catenin and promotes chondrogenesis , 2014, Cell and Tissue Banking.

[4]  S-H Lee,et al.  The small molecule indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity , 2013, International Journal of Obesity.

[5]  P. Backeljauw,et al.  Low incidence of pathology detection and high cost of screening in the evaluation of asymptomatic short children. , 2013, The Journal of pediatrics.

[6]  C. Hartmann,et al.  Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation. , 2013, Bone.

[7]  D. Ornitz,et al.  Development of the endochondral skeleton. , 2013, Cold Spring Harbor perspectives in biology.

[8]  Debbie Y. Dao,et al.  Cartilage‐specific β‐catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[9]  P. Collett-Solberg,et al.  Adverse effects of growth hormone replacement therapy in children. , 2011, Arquivos brasileiros de endocrinologia e metabologia.

[10]  J. Woodgett,et al.  Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression. , 2011, Endocrinology.

[11]  Kozo Nakamura,et al.  Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes. , 2008, The Journal of clinical investigation.

[12]  R. O’Keefe,et al.  Inhibition of β-catenin signaling causes defects in postnatal cartilage development , 2008, Journal of Cell Science.

[13]  J. Guénet,et al.  Mutations in the gene encoding the low-density lipoprotein receptor LRP4 cause abnormal limb development in the mouse. , 2006, Genomics.

[14]  Tomohiro Otani,et al.  Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. , 2005, The Journal of biological chemistry.

[15]  J. Baron,et al.  Fundamental limits on longitudinal bone growth: growth plate senescence and epiphyseal fusion , 2004, Trends in Endocrinology & Metabolism.

[16]  Gerhard Eisenbrand,et al.  Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine , 2004, Journal of Cancer Research and Clinical Oncology.

[17]  Brenda J. Crowe,et al.  Effect of growth hormone treatment on adult height in peripubertal children with idiopathic short stature: a randomized, double-blind, placebo-controlled trial. , 2004, The Journal of clinical endocrinology and metabolism.

[18]  P. McCrea,et al.  Interactions between Sox9 and β-catenin control chondrocyte differentiation , 2004 .

[19]  P. McCrea,et al.  Interactions between Sox9 and beta-catenin control chondrocyte differentiation. , 2004, Genes & development.

[20]  J. Wit,et al.  Systemic and local regulation of the growth plate. , 2003, Endocrine reviews.

[21]  H. Kronenberg,et al.  Developmental regulation of the growth plate , 2003, Nature.

[22]  J. Baron,et al.  Effects of estrogen on growth plate senescence and epiphyseal fusion , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[23]  D. Stevens,et al.  Thyroid Hormones Regulate Hypertrophic Chondrocyte Differentiation and Expression of Parathyroid Hormone‐Related Peptide and Its Receptor During Endochondral Bone Formation , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[24]  C. Chuong,et al.  Successive formative stages of precartilaginous mesenchymal condensations in vitro: Modulation of cell adhesion by Wnt‐7A and BMP‐2 , 1999, Journal of cellular physiology.

[25]  B. Lanske,et al.  Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[26]  A. Brown,et al.  Inhibition of chondrogenesis by Wnt gene expression in vivo and in vitro. , 1997, Developmental biology.