Correlation of third ventricular enlargement and EEG slow wave activity in schizophrenic patients

Twenty-eight schizophrenic patients and 22 normal control subjects underwent magnetic resonance imaging (MRI) and topographic electroencephalography (EEG) in a study attempting to correlate morphological and electrophysiological findings. Schizophrenic patients had larger anterior horns of the lateral ventricles and third ventricles than normal control subjects. Schizophrenic patients showed more delta wave activity in the right parietooccipital region than normal control subjects. Alpha 2 wave activity was reduced in the entire region in schizophrenic patients. In schizophrenic patients, a significant positive correlation was seen between the area of the third ventricle and delta wave activity in the right occipital region. These results suggest that schizophrenic patients may have a dysfunction of diencephalic structures associated with morphological abnormality.

[1]  R. Coppola,et al.  Computerized EEG in schizophrenia. , 1988, Schizophrenia bulletin.

[2]  J. T. Marsh,et al.  AUDITORY POTENTIALS DURING ACOUSTIC HABITUATION: COCHLEAR NUCLEUS, CEREBELLUM AND AUDITORY CORTEX. , 1964, Electroencephalography and clinical neurophysiology.

[3]  P. Stratta,et al.  Hemispheric asymmetries and schizophrenia: A preliminary magnetic resonance imaging study , 1989, Biological Psychiatry.

[4]  Joseph E. Schwartz,et al.  Brain morphology in first-episode schizophrenic-like psychotic patients: A quantitative magnetic resonance imaging study , 1991, Biological Psychiatry.

[5]  Bernard J. Ransil,et al.  Associations of handedness with hair color and learning disabilities , 1987, Neuropsychologia.

[6]  Toshiro Miyauchi,et al.  Computerized EEG in Schizophrenic patients , 1990, Biological Psychiatry.

[7]  T M Itil,et al.  Qualitative and quantitative EEG findings in schizophrenia. , 1977, Schizophrenia bulletin.

[8]  J. Stevens,et al.  Neuropathology of schizophrenia. , 1982, Archives of general psychiatry.

[9]  J. Kelsoe,et al.  Quantitative neuroanatomy in schizophrenia. A controlled magnetic resonance imaging study. , 1988, Archives of general psychiatry.

[10]  P Gloor,et al.  Brain lesions that produce delta waves in the EEG , 1977, Neurology.

[11]  L. Berg,et al.  Frequency analysis of the resting awake EEG in mild senile dementia of Alzheimer type. , 1983, Electroencephalography and clinical neurophysiology.

[12]  R Coppola,et al.  Computed electroencephalographic activity mapping in schizophrenia. The resting state reconsidered. , 1987, Archives of general psychiatry.

[13]  D. Ewen Cameron,et al.  THE ELECTRENCEPHALOGRAM OF SCHIZOPHRENICS DURING INSULIN TREATMENTS , 1937 .

[14]  P. Stratta,et al.  Reduced temporal lobe areas in schizophrenia: Preliminary evidences from a controlled multiplanar magnetic resonance imaging study , 1990, Biological Psychiatry.

[15]  F. Gibbs,et al.  THE LIKENESS OF THE CORTICAL DYSRHYTHMIAS OF SCHIZOPHRENIA AND PSYCHOMOTOR EPILEPSY , 1938 .

[16]  Y. Nakamura,et al.  DELTA WAVE PRODUCTION IN NEOCORTICAL EEG BY ACUTE LESIONS WITHIN THALAMUS AND HYPOTHALAMUS OF THE CAT. , 1964, Electroencephalography and clinical neurophysiology.

[17]  James C. Ehrhardt,et al.  Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study , 1992, Biological Psychiatry.

[18]  P. Stratta,et al.  Brain morphology in schizophrenia by Magnetic Resonance Imaging (MRI) , 1988, Acta psychiatrica Scandinavica.

[19]  C M Michel,et al.  Localization of the sources of EEG delta, theta, alpha and beta frequency bands using the FFT dipole approximation. , 1992, Electroencephalography and clinical neurophysiology.

[20]  N. Mano,et al.  Cortical polarization and experimentally produced delta waves in the cat. , 1968, Electroencephalography and clinical neurophysiology.

[21]  T. Gasser,et al.  Transformations towards the normal distribution of broad band spectral parameters of the EEG. , 1982, Electroencephalography and clinical neurophysiology.

[22]  D. Garver,et al.  Enlargement of cerebral third ventricle in psychotic patients with delayed response to neuroleptics , 1990, Biological Psychiatry.

[23]  A. Young,et al.  A Magnetic Resonance Imaging Study of Schizophrenia: Brain Structure and Clinical Symptoms , 1991, British Journal of Psychiatry.

[24]  R. Shelton,et al.  Cerebral structural pathology in schizophrenia: evidence for a selective prefrontal cortical defect. , 1988, The American journal of psychiatry.

[25]  D. Weinberger,et al.  Lateral cerebral ventricular enlargement in chronic schizophrenia. , 1979, Archives of general psychiatry.

[26]  B. Pakkenberg,et al.  Stereological quantitation of human brains from normal and schizophrenic individuals , 1992, Acta neurologica Scandinavica. Supplementum.

[27]  J. Ehrhardt,et al.  Magnetic resonance imaging of the brain in schizophrenia. The pathophysiologic significance of structural abnormalities. , 1990, Archives of general psychiatry.

[28]  J. Kelsoe,et al.  Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study. , 1989, The American journal of psychiatry.

[29]  R. Coppola,et al.  Alpha frequency in schizophrenia: an association with enlarged cerebral ventricles. , 1988, The American journal of psychiatry.

[30]  F. Reed Murtagh,et al.  Imaging Anatomy of the Head and Spine: A Photographic Color Atlas of Mri, Ct, Gross, and Microscopic Anatomy in Axial Coronal and Sagittal Planes , 1990 .

[31]  J. Davis,et al.  Comparative doses and costs of antipsychotic medication. , 1976, Archives of general psychiatry.

[32]  R Jagoe,et al.  Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder. , 1986, Archives of general psychiatry.

[33]  T. Yamamoto,et al.  Delta waves in the EEGs of patients with intracerebral hemorrhage. , 1981, Archives of Neurology.

[34]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[35]  T. Crow,et al.  Schizophrenia as an anomaly of development of cerebral asymmetry. A postmortem study and a proposal concerning the genetic basis of the disease. , 1989, Archives of general psychiatry.