Insulin activates protein kinase B, inhibits glycogen synthase kinase‐3 and activates glycogen synthase by rapamycin‐insensitive pathways in skeletal muscle and adipose tissue
暂无分享,去创建一个
[1] D. Turnbull,et al. Insulin action in cultured human myoblasts: contribution of different signalling pathways to regulation of glycogen synthesis. , 1996, The Biochemical journal.
[2] E. Van Obberghen,et al. Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport. , 1996, European journal of biochemistry.
[3] A. Depaoli-Roach,et al. Regulation of Both Glycogen Synthase and PHAS-I by Insulin in Rat Skeletal Muscle Involves Mitogen-activated Protein Kinase-independent and Rapamycin-sensitive Pathways (*) , 1996, The Journal of Biological Chemistry.
[4] P. Cohen,et al. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B , 1995, Nature.
[5] Y. Le Marchand-Brustel,et al. Insulin Stimulation of Mitogen-activated Protein Kinase, p90rsk, and p70 S6 Kinase in Skeletal Muscle of Normal and Insulin-resistant Mice , 1995, The Journal of Biological Chemistry.
[6] Philip R. Cohen,et al. Comparison of the specificities of p70 S6 kinase and MAPKAP kinase‐1 identifies a relatively specific substrate for p70 S6 kinase: the N‐terminal kinase domain of MAPKAP kinase‐1 is essential for peptide phosphorylation , 1995, FEBS letters.
[7] Philip R. Cohen,et al. PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*) , 1995, The Journal of Biological Chemistry.
[8] P. Cohen,et al. Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells. , 1995, European journal of biochemistry.
[9] N. J. Edgell,et al. Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells. , 1995, The Biochemical journal.
[10] P. Cuatrecasas,et al. Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin (*) , 1995, The Journal of Biological Chemistry.
[11] R. Roth,et al. Insulin stimulates the kinase activity of RAC‐PK, a pleckstrin homology domain containing ser/thr kinase. , 1995, The EMBO journal.
[12] B. Burgering,et al. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction , 1995, Nature.
[13] K. Siddle,et al. Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase. , 1995, The Biochemical journal.
[14] C. Proud,et al. Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase. , 1994, The Biochemical journal.
[15] J. Lawrence,et al. Activation of ribosomal protein S6 kinases does not increase glycogen synthesis or glucose transport in rat adipocytes. , 1994, The Journal of biological chemistry.
[16] Ivan Dikic,et al. PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation , 1994, Current Biology.
[17] P. Cohen,et al. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor , 1994, Current Biology.
[18] P. Cohen,et al. The α‐isoform of glycogen synthase kinase‐3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase‐activated protein kinase‐1 in vitro , 1994, FEBS letters.
[19] P. Cohen,et al. Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. , 1993, The Biochemical journal.
[20] C. Proud,et al. Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B. , 1993, The Biochemical journal.
[21] P. Cohen,et al. Purification and characterisation of the insulin-stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II. , 1991, European journal of biochemistry.
[22] P. Dent,et al. The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle , 1990, Nature.
[23] P. Cohen,et al. Evidence for communication between nerve growth factor and protein tyrosine phosphorylation , 1990, FEBS letters.
[24] P. Cohen,et al. Regulation of protein phosphatase-1G from rabbit skeletal muscle. 2. Catalytic subunit translocation is a mechanism for reversible inhibition of activity toward glycogen-bound substrates. , 1989, European journal of biochemistry.
[25] W. Benjamin,et al. Insulin action rapidly decreases multifunctional protein kinase activity in rat adipose tissue. , 1988, The Journal of biological chemistry.
[26] P. Cohen,et al. The protein phosphatases involved in cellular regulation. Purification and characterisation of the glycogen-bound form of protein phosphatase-1 from rabbit skeletal muscle. , 1985, European journal of biochemistry.
[27] P. Cohen,et al. Glycogen synthase from rabbit skeletal muscle; effect of insulin on the state of phosphorylation of the seven phosphoserine residues in vivo. , 2005, European journal of biochemistry.
[28] P. Cohen,et al. The purification and properties of rabbit skeletal muscle glycogen synthase. , 1976, European journal of biochemistry.
[29] M. M. Bradford. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.