TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP

[1]  N. Bottini,et al.  Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. , 2014, The Journal of clinical investigation.

[2]  H. Fujino,et al.  TRPM8 has a key role in experimental colitis‐induced visceral hyperalgesia in mice , 2014, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[3]  V. Cerovic,et al.  Intestinal macrophages and dendritic cells: what's the difference? , 2014, Trends in immunology.

[4]  S. Frye,et al.  The Lipid Kinase PIP5K1C Regulates Pain Signaling and Sensitization , 2014, Neuron.

[5]  J. Fierer,et al.  Altered expression and localization of ion transporters contribute to diarrhea in mice with Salmonella-induced enteritis. , 2013, Gastroenterology.

[6]  W. Agace,et al.  Dendritic cell subsets in the intestinal lamina propria: Ontogeny and function , 2013, European journal of immunology.

[7]  D. McKemy,et al.  TRPM8 activation attenuates inflammatory responses in mouse models of colitis , 2013, Proceedings of the National Academy of Sciences.

[8]  W. Krajewska,et al.  Transient Receptor Potential Vanilloid 4 blockade protects against experimental colitis in mice: a new strategy for inflammatory bowel diseases treatment? , 2012, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[9]  C. Belmonte,et al.  Direct inhibition of the cold-activated TRPM8 ion channel by Gαq , 2012, Nature Cell Biology.

[10]  P. Insel,et al.  Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets. , 2012, The Journal of clinical investigation.

[11]  M. Neurath,et al.  The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons , 2012, Journal of Gastroenterology.

[12]  A. A. Romanovsky,et al.  Pharmacological Blockade of the Cold Receptor TRPM8 Attenuates Autonomic and Behavioral Cold Defenses and Decreases Deep Body Temperature , 2012, The Journal of Neuroscience.

[13]  H. Hammad,et al.  The neuropeptide calcitonin gene‐related peptide affects allergic airway inflammation by modulating dendritic cell function , 2011, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[14]  M. Neurath,et al.  TRPA1 and substance P mediate colitis in mice. , 2011, Gastroenterology.

[15]  Qi Li,et al.  Cold temperature induces mucin hypersecretion from normal human bronchial epithelial cells in vitro through a transient receptor potential melastatin 8 (TRPM8)-mediated mechanism. , 2011, The Journal of allergy and clinical immunology.

[16]  Jing Yang,et al.  A novel role for TRPM8 in visceral afferent function , 2011, PAIN®.

[17]  Hiroshi Yamamoto,et al.  Calcitonin Gene-Related Peptide Is an Important Regulator of Cutaneous Immunity: Effect on Dendritic Cell and T Cell Functions , 2011, The Journal of Immunology.

[18]  J. Fisher TRPM8 and dyspnea: from the frigid and fascinating past to the cool future? , 2011, Current opinion in pharmacology.

[19]  M. Neurath,et al.  Role of sensory neurons in colitis: increasing evidence for a neuroimmune link in the gut. , 2011, Inflammatory bowel diseases.

[20]  Sheng-Nan Wu,et al.  Characterization of TRPM8-Like Channels Activated by the Cooling Agent Icilin in the Macrophage Cell Line RAW 264.7 , 2011, The Journal of Membrane Biology.

[21]  Kinzo Matsumoto,et al.  Distribution of transient receptor potential vanilloid 1 channel-expressing nerve fibers in mouse rectal and colonic enteric nervous system: relationship to peptidergic and nitrergic neurons , 2011, Neuroscience.

[22]  L. Eckmann,et al.  Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9–driven antiinflammatory cytokine production , 2010, The Journal of experimental medicine.

[23]  Moe Tsutsumi,et al.  Topical application of TRPM8 agonists accelerates skin permeability barrier recovery and reduces epidermal proliferation induced by barrier insult: role of cold‐sensitive TRP receptors in epidermal permeability barrier homoeostasis , 2010, Experimental dermatology.

[24]  E. Pintér,et al.  The Role of Transient Receptor Potential Vanilloid 1 (Trpv1) Receptors in Dextran Sulfate-Induced Colitis in Mice , 2010, Journal of Molecular Neuroscience.

[25]  Jongdae Lee,et al.  ERK activation drives intestinal tumorigenesis in Apcmin/+ mice , 2010, Nature Medicine.

[26]  U. Yrlid,et al.  Subsets of migrating intestinal dendritic cells , 2010, Immunological reviews.

[27]  B. Holzmann,et al.  The Neuropeptide Calcitonin Gene-related Peptide Causes Repression of Tumor Necrosis Factor-α Transcription and Suppression of ATF-2 Promoter Recruitment in Toll-like Receptor-stimulated Dendritic Cells♦ , 2009, The Journal of Biological Chemistry.

[28]  L. Blackshaw,et al.  TRP channels: new targets for visceral pain , 2009, Gut.

[29]  T. Akasu,et al.  Expression of the TRPM8-immunoreactivity in dorsal root ganglion neurons innervating the rat urinary bladder , 2009, Neuroscience Research.

[30]  P. Zygmunt,et al.  Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain , 2009, Neuroscience.

[31]  L. Blackshaw,et al.  Role of TRPV1 in high-threshold rat colonic splanchnic afferents is revealed by inflammation , 2009, Neuroscience Letters.

[32]  J. Weinstock,et al.  Absence of the SP/SP Receptor Circuitry in the Substance P-Precursor Knockout Mice or SP Receptor, Neurokinin (NK)1 Knockout Mice Leads to an Inhibited Cytokine Response in Granulomas Associated with Murine Taenia crassiceps Infection , 2008, The Journal of parasitology.

[33]  J. Bornstein,et al.  Distinct chemical classes of medium-sized transient receptor potential channel vanilloid 1-immunoreactive dorsal root ganglion neurons innervate the adult mouse jejunum and colon , 2008, Neuroscience.

[34]  R. Penner,et al.  TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration , 2008, Nature Medicine.

[35]  A. Patapoutian,et al.  Visualizing Cold Spots: TRPM8-Expressing Sensory Neurons and Their Projections , 2008, The Journal of Neuroscience.

[36]  Wendy M. Knowlton,et al.  Diversity in the Neural Circuitry of Cold Sensing Revealed by Genetic Axonal Labeling of Transient Receptor Potential Melastatin 8 Neurons , 2007, The Journal of Neuroscience.

[37]  Steffen Jung,et al.  Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells , 2007, Proceedings of the National Academy of Sciences.

[38]  H. Okamoto,et al.  Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice , 2007, Proceedings of the National Academy of Sciences.

[39]  G. Holtmann,et al.  Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice: spinal cord c-Fos expression and behavior. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[40]  A. Miranda,et al.  The role of transient receptor potential vanilloid 1 in mechanical and chemical visceral hyperalgesia following experimental colitis , 2007, Neuroscience.

[41]  C. Molina,et al.  Negative Regulation of TLR Responses by the Neuropeptide CGRP Is Mediated by the Transcriptional Repressor ICER1 , 2007, The Journal of Immunology.

[42]  V. Di Marzo,et al.  Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloids. , 2007, Experimental cell research.

[43]  A. Patapoutian,et al.  TRPM8 Is Required for Cold Sensation in Mice , 2007, Neuron.

[44]  C. Schneider,et al.  Stimulation of neuronal receptors, neuropeptides and cytokines during experimental oil of mustard colitis , 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[45]  D. Andersson,et al.  Modulation of the Cold-Activated Channel TRPM8 by Lysophospholipids and Polyunsaturated Fatty Acids , 2007, The Journal of Neuroscience.

[46]  G. MacQueen,et al.  Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation , 2007, Gut.

[47]  Stefan Wirtz,et al.  Chemically induced mouse models of intestinal inflammation , 2007, Nature Protocols.

[48]  H. Koerber,et al.  Transient receptor potential vanilloid 1-immunopositive neurons in the mouse are more prevalent within colon afferents compared to skin and muscle afferents , 2006, Neuroscience.

[49]  Y. Panchin,et al.  Ca2+-independent Phospholipase A2-dependent Gating of TRPM8 by Lysophospholipids* , 2006, Journal of Biological Chemistry.

[50]  M. Creer,et al.  Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium. , 2005, American journal of physiology. Cell physiology.

[51]  Shigeo Kobayashi,et al.  TRPM8 protein localization in trigeminal ganglion and taste papillae. , 2005, Brain research. Molecular brain research.

[52]  I. Michailidis,et al.  PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain , 2005, Nature Neuroscience.

[53]  M. D'Andrea,et al.  Vanilloid receptor 1 antagonists attenuate disease severity in dextran sulphate sodium‐induced colitis in mice , 2004, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[54]  P. Holzer Vanilloid receptor TRPV1: hot on the tongue and inflaming the colon , 2004, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[55]  A. Perraud,et al.  Novel aspects of signaling and ion-homeostasis regulation in immunocytes. The TRPM ion channels and their potential role in modulating the immune response. , 2004, Molecular immunology.

[56]  Lei Zhang,et al.  Thermosensitive transient receptor potential channels in vagal afferent neurons of the mouse. , 2004, American journal of physiology. Gastrointestinal and liver physiology.

[57]  R. Arsenescu,et al.  Substance P Regulates Th1-Type Colitis in IL-10 Knockout Mice1 , 2003, The Journal of Immunology.

[58]  P. McIntyre,et al.  A TRP Channel that Senses Cold Stimuli and Menthol , 2002, Cell.

[59]  D. McKemy,et al.  Identification of a cold receptor reveals a general role for TRP channels in thermosensation , 2002, Nature.

[60]  Lawrence O. Christensen,et al.  Dictionary of Missouri Biography , 1999 .

[61]  G. Adler,et al.  Calcitonin gene-related peptide mediates the protective effect of sensory nerves in a model of colonic injury. , 1998, The Journal of pharmacology and experimental therapeutics.

[62]  Moon Young,et al.  United States Post Office , 1955 .

[63]  M. Neurath,et al.  Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis. , 2012, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[64]  J. Vinel,et al.  Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice. , 2011, Gastroenterology.

[65]  P. Holzer TRP channels in the digestive system. , 2011, Current pharmaceutical biotechnology.

[66]  M. Washington,et al.  Protective roles of alpha-calcitonin and beta-calcitonin gene-related peptide in spontaneous and experimentally induced colitis. , 2008, Digestive diseases and sciences.

[67]  J. A. Peters,et al.  Transient receptor potential cation channels in disease. , 2007, Physiological reviews.

[68]  M. Washington,et al.  Protective Roles of α-Calcitonin and β-Calcitonin Gene-Related Peptide in Spontaneous and Experimentally Induced Colitis , 2007, Digestive Diseases and Sciences.

[69]  R. Longstreth The Buildings of Main Street: A Guide to American Commercial Architecture , 1987 .

[70]  Marian M. Ohman St. Francois County , 1980 .

[71]  J. Poppeliers,et al.  What Style Is It , 1978 .