Copper chelator ATN-224 inhibits endothelial function by multiple mechanisms.

[1]  A. Harris,et al.  Phase I Study of Copper-Binding Agent ATN-224 in Patients with Advanced Solid Tumors , 2008, Clinical Cancer Research.

[2]  S. yet,et al.  Heme oxygenase-1 promotes neovascularization in ischemic heart by coinduction of VEGF and SDF-1. , 2008, Journal of molecular and cellular cardiology.

[3]  D. Shaw,et al.  Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling , 2008, Proceedings of the National Academy of Sciences.

[4]  K. Erdmann,et al.  Heme oxygenase-1 is a novel target and antioxidant mediator of S-adenosylmethionine. , 2008, Biochemical and biophysical research communications.

[5]  K. Sakurai,et al.  Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells. , 2008, Microvascular research.

[6]  D. Shaw,et al.  Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224) , 2008, British Journal of Cancer.

[7]  M. Shibuya,et al.  Novel antiangiogenic pathway of thrombospondin‐1 mediated by suppression of the cell cycle , 2007, Cancer science.

[8]  Brian N Chorley,et al.  Identification of polymorphic antioxidant response elements in the human genome. , 2007, Human molecular genetics.

[9]  P. Agostinis,et al.  Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy , 2007, Apoptosis.

[10]  Aiqing He,et al.  The Unfolded Protein Response Is an Important Regulator of Inflammatory Genes in Endothelial Cells , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[11]  D. Shaw,et al.  Copper Binding by Tetrathiomolybdate Attenuates Angiogenesis and Tumor Cell Proliferation through the Inhibition of Superoxide Dismutase 1 , 2006, Clinical Cancer Research.

[12]  T. O’Halloran,et al.  Activation of superoxide dismutases: putting the metal to the pedal. , 2006, Biochimica et biophysica acta.

[13]  A. Mobasheri,et al.  Heterogeneous expression of the aquaporin 1 (AQP1) water channel in tumors of the prostate, breast, ovary, colon and lung: a study using high density multiple human tumor tissue microarrays. , 2005, International journal of oncology.

[14]  Marios C. Papadopoulos,et al.  Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption , 2005, Nature.

[15]  K. Channon,et al.  Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells. , 2005, Cardiovascular research.

[16]  C. Song,et al.  Induction of heme oxygenase-1 is involved in anti-proliferative effects of paclitaxel on rat vascular smooth muscle cells. , 2004, Biochemical and biophysical research communications.

[17]  C. Chen,et al.  Inhibition of human vascular endothelial cells proliferation by terbinafine , 2004, International journal of cancer.

[18]  M. Dewhirst,et al.  Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[19]  J. Folkman,et al.  Fundamental concepts of the angiogenic process. , 2003, Current molecular medicine.

[20]  J. Cook,et al.  Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway. , 2003, Current pharmaceutical design.

[21]  R. Sainson,et al.  Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1. , 2003, Microvascular research.

[22]  V. Husak,et al.  R136K fibroblast growth factor-1 mutant induces heparin-independent migration of endothelial cells through fibrin glue. , 2003, Journal of vascular surgery.

[23]  H. Nishimatsu,et al.  Constitutive activation of proto-oncogen protein p21 induces cell cycle arrest in the G1 phase in contact-inhibited vascular endothelial cells. , 2002, Hypertension research : official journal of the Japanese Society of Hypertension.

[24]  S. Merajver,et al.  Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis. , 2002, Cancer research.

[25]  S. Ryter,et al.  Heme oxygenase-1: molecular mechanisms of gene expression in oxygen-related stress. , 2002, Antioxidants & redox signaling.

[26]  G. Brewer.  Copper Control as an Antiangiogenic Anticancer Therapy: Lessons from Treating Wilson's Disease , 2001, Experimental biology and medicine.

[27]  M. Pfaffl,et al.  A new mathematical model for relative quantification in real-time RT-PCR. , 2001, Nucleic acids research.

[28]  S. Merajver,et al.  The Role of Copper Suppression as an Antiangiogenic Strategy in Head and Neck Squamous Cell Carcinoma , 2001, The Laryngoscope.

[29]  G. Hu.  Copper stimulates proliferation of human endothelial cells under culture , 1998, Journal of cellular biochemistry.

[30]  A. Verkman,et al.  Isolation of the human aquaporin-1 promoter and functional characterization in human erythroleukemia cell lines. , 1998, Genomics.

[31]  E. Nabel,et al.  Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[32]  T. Glover,et al.  Molecular structure of the Menkes disease gene (ATP7A). , 1995, Genomics.

[33]  S. Brem,et al.  Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor. , 1990, The American journal of pathology.

[34]  S. Merajver,et al.  Radiotherapy and antiangiogenic TM in lung cancer. , 2002, Neoplasia.

[35]  E. Vadai,et al.  Cu/Zn superoxide dismutase plays a role in angiogenesis , 2002, International journal of cancer.

[36]  S. Merajver,et al.  Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[37]  R. Palmer,et al.  Characterization and quantification of copper sulfate-induced vascularization of the rabbit cornea. , 1988, The American journal of pathology.