Primary anorexia nervosa: Gastric emptying and antral motor activity in 53 patients

In 53 consecutive patients with primary anorexia nervosa, gastric emptying of a semisolid meal was significantly slower than in 24 healthy subjects. Slow emptying tended to be associated with low serum potassium, low body weight, and long illness duration. Antral contraction amplitudes were lower than in healthy subjects and failed to increase postcibally, whereas contraction frequency and rhythmicity seemed unaffected. After the gastric prokinetic agent, cisapride, 8 mg intravenously administered double-blind, emptying was significantly faster than after placebo. The recognition of impaired gastric motility may be important in the management of anorexia nervosa.

[1]  J. Dent,et al.  Relationship of the motor activity of the antrum, pylorus, and duodenum to gastric emptying of a solid-liquid mixed meal. , 1988, Gastroenterology.

[2]  P H Robinson,et al.  Determinants of delayed gastric emptying in anorexia nervosa and bulimia nervosa. , 1988, Gut.

[3]  A. Zinsmeister,et al.  Gastric electromechanical and neurohormonal function in anorexia nervosa. , 1987, Gastroenterology.

[4]  R. Abdu,et al.  Acute gastric necrosis in anorexia nervosa and bulimia. Two case reports. , 1987, Archives of surgery.

[5]  H. Bergmann,et al.  Intravenous cisapride accelerates delayed gastric emptying and increases antral contraction amplitude in patients with primary anorexia nervosa. , 1987, Gastroenterology.

[6]  L. Barbara,et al.  Effect of chronic administration of cisapride on gastric emptying of a solid meal and on dyspeptic symptoms in patients with idiopathic gastroparesis. , 1987, Gut.

[7]  H. Bergmann,et al.  Alimentary tract andpancreas Oesophageal andgastric motility disorders inpatients categorised ashaving primary anorexia nervosa , 1986 .

[8]  R. Alloway,et al.  Neuropathy and myopathy in two patients with anorexia and bulimia nervosa. , 1985, Journal of neurology, neurosurgery, and psychiatry.

[9]  C. Lindboe,et al.  The neuromuscular system in patients with anorexia nervosa: electrophysiological and histologic studies. , 1984, Clinical neuropathology.

[10]  P. Garfinkel,et al.  A comparison between muscle function and body composition in anorexia nervosa: the effect of refeeding. , 1983, The American journal of clinical nutrition.

[11]  S. Krinsky,et al.  Gastric emptying and obesity , 1983 .

[12]  R. Heading,et al.  Abnormal Gastric Emptying in Primary Anorexia Nervosa , 1981, British Journal of Psychiatry.

[13]  A. Dekker,et al.  Acute gastric dilatation with infarction and perforation , 1981, Gut.

[14]  D. Castell,et al.  Altered gastric emptying and secretion in primary anorexia nervosa. , 1979, Gastroenterology.

[15]  J S Borer,et al.  Effects of Self-Induced Starvation on Cardiac Size and Function in Anorexia Nervosa , 1978, Circulation.

[16]  J. Meyer,et al.  Gastric emptying rates of solid food in relation to body size. , 1978, Gastroenterology.

[17]  E. Franken,et al.  Acute gastric dilatation in neglected children. , 1978, AJR. American journal of roentgenology.

[18]  A. Klidjian,et al.  Acute Gastric Dilatation in Anorexia Nervosa , 1974, British medical journal.

[19]  B A Scobie,et al.  ACUTE GASTRIC DILATATION AND DUODENAL ILEUS IN ANOREXIA NERVOSA , 1973, The Medical journal of Australia.

[20]  D S Evans,et al.  Acute dilatation and spontaneous rupture of the stomach , 1968, The British journal of surgery.

[21]  G. Russell.  Acute Dilatation of the Stomach in a Patient with Anorexia Nervosa , 1966, British Journal of Psychiatry.

[22]  E. Simonson,et al.  The Biology of Human Starvation. , 1951 .

[23]  R. Passmore.  Mixed deficiency diseases in India; a clinical description. , 1947, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[24]  Acute Dilatation of the Stomach , 1901, The Hospital.

[25]  B. Mamoli,et al.  Subklinische Polyneuropathien bei Anorexia nervosa , 1984 .

[26]  S. Holm.  A Simple Sequentially Rejective Multiple Test Procedure , 1979 .