Downregulation of several fibulin genes in prostate cancer

Fibulins, encoded by FBLN genes, are extracellular matrix proteins influencing cell adhesion and migration. Altered expression of fibulins is associated with progression of several cancer types, but has not been studied in prostate cancer.

[1]  D. Katsaros,et al.  Estrogen induction and overexpression of fibulin-1C mRNA in ovarian cancer cells , 2002, Oncogene.

[2]  P. Humphrey,et al.  Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma. , 1993, Human pathology.

[3]  G. Jenster,et al.  Gene expression profiling of the human prostate zones , 2006, BJU international.

[4]  P. Laurent-Puig,et al.  Human fibulin‐4: analysis of its biosynthetic processing and mRNA expression in normal and tumour tissues , 2001, FEBS letters.

[5]  C. Edgell,et al.  Testican-1: a differentially expressed proteoglycan with protease inhibiting activities. , 2004, International review of cytology.

[6]  Takako Sasaki,et al.  Fibrillin-1 Interactions with Fibulins Depend on the First Hybrid Domain and Provide an Adaptor Function to Tropoelastin* , 2007, Journal of Biological Chemistry.

[7]  R. Timpl,et al.  Characterization of a novel calcium-binding 90-kDa glycoprotein (BM-90) shared by basement membranes and serum. , 1990, European journal of biochemistry.

[8]  H. Hutter,et al.  Fibulin-1C and Fibulin-1D splice variants have distinct functions and assemble in a hemicentin-dependent manner , 2005, Development.

[9]  R. Dahiya,et al.  Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[10]  R. Timpl,et al.  Fibulins: a versatile family of extracellular matrix proteins , 2003, Nature Reviews Molecular Cell Biology.

[11]  G. Hammond,et al.  Evidence That Fibulin Family Members Contribute to the Steroid-dependent Extravascular Sequestration of Sex Hormone-binding Globulin* , 2006, Journal of Biological Chemistry.

[12]  A. Czirók,et al.  Fibulin-1 suppression of fibronectin-regulated cell adhesion and motility. , 2001, Journal of cell science.

[13]  D. Notterman,et al.  GROα Is Highly Expressed in Adenocarcinoma of the Colon and Down-Regulates Fibulin-1 , 2006, Clinical Cancer Research.

[14]  G. Orend.  Potential oncogenic action of tenascin-C in tumorigenesis. , 2005, The international journal of biochemistry & cell biology.

[15]  L. Greene,et al.  Fibulins: physiological and disease perspectives , 2003, EMBO reports.

[16]  F. Smedts,et al.  Expression of periglandular tenascin-C and basement membrane laminin in normal prostate, benign prostatic hyperplasia and prostate carcinoma. , 1998, British journal of urology.

[17]  M. Burdick,et al.  Distinct CXC chemokines mediate tumorigenicity of prostate cancer cells. , 1999, The American journal of pathology.

[18]  C. Stephan,et al.  Free PSA forms in prostatic tissue and sera of prostate cancer patients: analysis by 2-DE and western blotting of immunopurified samples. , 2007, Clinical biochemistry.

[19]  S. Ménard,et al.  Immunological and pathobiological roles of fibulin-1 in breast cancer , 2004, Oncogene.

[20]  W. Schulz,et al.  Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies. , 2006, Biochemical pharmacology.

[21]  Werner Götz,et al.  The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo , 1996, The Histochemical Journal.

[22]  J. Schwarzbauer,et al.  Elastic Fibers: Building Bridges Between Cells and Their Matrix , 2002, Current Biology.

[23]  W. Schiemann,et al.  Fibulin-5 antagonizes vascular endothelial growth factor (VEGF) signaling and angiogenic sprouting by endothelial cells. , 2004, DNA and cell biology.

[24]  Horst Buerger,et al.  Distinct amplification of an untranslated regulatory sequence in the egfr gene contributes to early steps in breast cancer development. , 2003, Cancer research.

[25]  Thomas Lengauer,et al.  Factor interaction analysis for chromosome 8 and DNA methylation alterations highlights innate immune response suppression and cytoskeletal changes in prostate cancer , 2007, Molecular Cancer.

[26]  W. Gallagher,et al.  Fibulins and cancer: friend or foe? , 2005, Trends in molecular medicine.

[27]  Tasuku Honjo,et al.  Fibulin-5/DANCE is essential for elastogenesis in vivo , 2002, Nature.

[28]  H. Dietz,et al.  Perturbations of Vascular Homeostasis and Aortic Valve Abnormalities in Fibulin-4 Deficient Mice , 2007, Circulation research.

[29]  B. Lewis,et al.  Effects of fibulin-5 on attachment, adhesion, and proliferation of primary human endothelial cells. , 2006, Biochemical and biophysical research communications.

[30]  A. Gazdar,et al.  Aberrant promoter methylation of laminin-5-encoding genes in prostate cancers and its relationship to clinicopathological features. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[31]  R. Margueron,et al.  Transcriptional and posttranscriptional regulation of fibulin-1 by estrogens leads to differential induction of messenger ribonucleic acid variants in ovarian and breast cancer cells. , 2005, Endocrinology.

[32]  R. Timpl,et al.  Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4. , 1999, Matrix biology : journal of the International Society for Matrix Biology.

[33]  R Engers,et al.  Coordinate hypermethylation at specific genes in prostate carcinoma precedes LINE-1 hypomethylation , 2004, British Journal of Cancer.

[34]  Alan Wells,et al.  Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor , 2001, The Journal of cell biology.

[35]  J. Kramer,et al.  Selective assembly of fibulin‐1 splice variants reveals distinct extracellular matrix networks and novel functions for perlecan/UNC‐52 splice variants , 2006, Developmental dynamics : an official publication of the American Association of Anatomists.

[36]  Paul Coucke,et al.  Homozygosity for a missense mutation in fibulin-5 (FBLN5) results in a severe form of cutis laxa. , 2002, Human molecular genetics.

[37]  T. Sakakura,et al.  Tenascin expression and postnatal development of the human prostate. , 1994, The International journal of developmental biology.

[38]  T. Stamey,et al.  Genetic profiling of Gleason grade 4/5 prostate cancer: which is the best prostatic control tissue? , 2003, The Journal of urology.

[39]  M. Wirth,et al.  Quantitative multi‐gene expression profiling of primary prostate cancer , 2006 .