Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells.

[1]  M. Isono,et al.  Increased Glomerular and Tubular Expression of Transforming Growth Factor-β1, Its Type II Receptor, and Activation of the Smad Signaling Pathway in the db/db Mouse , 2001 .

[2]  B. Y. Chin,et al.  Stimulation of pro-α1(I) collagen by TGF-β1 in mesangial cells: role of the p38 MAPK pathway , 2001 .

[3]  J. Ou,et al.  Synergistic Cooperation between Sp1 and Smad3/Smad4 Mediates Transforming Growth Factor β1 Stimulation of α2(I)-Collagen (COL1A2) Transcription* , 2000, The Journal of Biological Chemistry.

[4]  K. Thai,et al.  Effects of diabetes and hypertension on glomerular transforming growth factor-beta receptor expression. , 2000, Kidney international.

[5]  K. Sharma,et al.  Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[6]  K. Isshiki,et al.  Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats. , 2000, Diabetes.

[7]  M. Isono,et al.  Stimulation of TGF-beta type II receptor by high glucose in mouse mesangial cells and in diabetic kidney. , 2000, American journal of physiology. Renal physiology.

[8]  J. Massagué,et al.  Transcriptional control by the TGF‐β/Smad signaling system , 2000 .

[9]  J. Petrik,et al.  The Renal Expression of Transforming Growth Factor-β Isoforms and Their Receptors in Acute and Chronic Experimental Diabetes in Rats. , 2000, Endocrinology.

[10]  In‐San Kim,et al.  Transcriptional regulation of fibronectin gene by phorbol myristate acetate in hepatoma cells: A negative role for NF‐κB , 2000, Journal of cellular biochemistry.

[11]  H. Lodish,et al.  Specificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteins. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[12]  S. Hubchak,et al.  TGF-beta1 activates MAP kinase in human mesangial cells: a possible role in collagen expression. , 1999, Kidney international.

[13]  D. C. Han,et al.  High glucose stimulates proliferation and collagen type I synthesis in renal cortical fibroblasts: mediation by autocrine activation of TGF-beta. , 1999, Journal of the American Society of Nephrology : JASN.

[14]  J. Yee,et al.  TGF-beta receptor expression and binding in rat mesangial cells: modulation by glucose and cyclic mechanical strain. , 1999, Kidney international.

[15]  S. Tashiro,et al.  ATF-2 Is a Common Nuclear Target of Smad and TAK1 Pathways in Transforming Growth Factor-β Signaling* , 1999, The Journal of Biological Chemistry.

[16]  P. Howe,et al.  TGF‐β induces fibronectin synthesis through a c‐Jun N‐terminal kinase‐dependent, Smad4‐independent pathway , 1999, The EMBO journal.

[17]  Jian-ming Li,et al.  Smad3-Smad4 and AP-1 Complexes Synergize in Transcriptional Activation of the c-Jun Promoter by Transforming Growth Factor β , 1999, Molecular and Cellular Biology.

[18]  G. King,et al.  Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. , 1999, The Journal of clinical investigation.

[19]  Yigong Shi,et al.  Crystal Structure of a Smad MH1 Domain Bound to DNA Insights on DNA Binding in TGF-β Signaling , 1998, Cell.

[20]  R. Derynck,et al.  Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription , 1998, Nature.

[21]  Denis Vivien,et al.  Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene , 1998, The EMBO journal.

[22]  Yanqing Zhu,et al.  Transforming Growth Factor-β1 Stimulates Protein Kinase A in Mesangial Cells* , 1998, The Journal of Biological Chemistry.

[23]  G. Jerums,et al.  Expression of transforming growth factor-beta1 and type IV collagen in the renal tubulointerstitium in experimental diabetes: effects of ACE inhibition. , 1998, Diabetes.

[24]  Kohei Miyazono,et al.  TGF-β signalling from cell membrane to nucleus through SMAD proteins , 1997, Nature.

[25]  C. Heldin,et al.  Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling , 1997, Nature.

[26]  R. Weinberg,et al.  Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[27]  G. King,et al.  Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. , 1997, The Journal of clinical investigation.

[28]  Masakazu Haneda,et al.  Mitogen-Activated Protein Kinase Cascade Is Activated in Glomeruli of Diabetic Rats and Glomerular Mesangial Cells Cultured Under High Glucose Conditions , 1997, Diabetes.

[29]  K. Sharma,et al.  Increased Renal Production of Transforming Growth Factor-β1 in Patients with Type II Diabetes , 1997, Diabetes.

[30]  H. Abboud,et al.  Expression of Transforming Growth Factor-β and Type IV Collagen in Early Streptozotocin-Induced Diabetes , 1997, Diabetes.

[31]  A. Pfeiffer,et al.  Elevated Plasma Levels of Transforming Growth Factor-β1 in NIDDM , 1996, Diabetes Care.

[32]  S. Bursell,et al.  Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor , 1996, Science.

[33]  M. Schwartz,et al.  Diabetes Complications--Why Is Glucose Potentially Toxic? , 1996, Science.

[34]  M. Daha,et al.  Effects of high glucose on the production of heparan sulfate proteoglycan by mesangial and epithelial cells. , 1996, Kidney international.

[35]  Y. Akai,et al.  Quantification of glomerular TGF-β1 mRNA in patients with diabetes mellitus , 1996 .

[36]  Jia Guo,et al.  Neutralization of TGF-β by Anti-TGF-β Antibody Attenuates Kidney Hypertrophy and the Enhanced Extracellular Matrix Gene Expression in STZ-Induced Diabetic Mice , 1996, Diabetes.

[37]  W. Border,et al.  Transforming Growth Factor β in Tissue Fibrosis , 1994 .

[38]  J. Kreisberg,et al.  High glucose and TGF beta 1 stimulate fibronectin gene expression through a cAMP response element. , 1994, Kidney international.

[39]  K. Thai,et al.  Expression of transforming growth factor-β1 during diabetic renal hypertrophy , 1994 .

[40]  K. Sharma,et al.  Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta. , 1994, The Journal of clinical investigation.

[41]  E Ruoslahti,et al.  Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[42]  Y. Tomino,et al.  mRNA Expression of Growth Factors in Glomeruli From Diabetic Rats , 1993, Diabetes.

[43]  Jeffrey L. Wrana,et al.  TGFβ signals through a heteromeric protein kinase receptor complex , 1992, Cell.

[44]  K. Sharma,et al.  High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β , 1992 .

[45]  T. Nakamura,et al.  E1A-responsive elements for repression of rat fibronectin gene transcription , 1992, Molecular and cellular biology.

[46]  E. Schleicher,et al.  Immunohistochemical localization of extracellular matrix components in human diabetic glomerular lesions. , 1991, The American journal of pathology.

[47]  F. DeRubertis,et al.  Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose. , 1989, The Journal of clinical investigation.

[48]  S. Hong,et al.  Extracellular signal-regulated kinase mediates stimulation of TGF-beta1 and matrix by high glucose in mesangial cells. , 2000, Journal of the American Society of Nephrology : JASN.

[49]  J. Egido,et al.  In situ non-radioactive detection of nuclear factors in paraffin sections by Southwestern histochemistry. , 1999, Kidney international.

[50]  U. Sauer,et al.  High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells. , 1998, The Journal of clinical investigation.

[51]  H. Abboud,et al.  Erratum: Expression of transforming growth factor-β and type IV collagen in early streptozotocin-induced diabetes (Diabetes (1997) 46 (473- 480)) , 1997 .