Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ
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E. R. Andersson | R. Sandberg | U. Lendahl | O. Kallioniemi | I. Screpanti | J. Mpindi | P. Kronqvist | L. Poellinger | D. Ramsköld | S. Jin | I. Chivukula | C. Sahlgren | V. Mamaeva | P. Östling | A. Mutvei | K. Lee | K. L. Lee | Olli-P. Kallioniemi | Indira V. Chivukula | Shaobo Jin | Veronika Mamaeva | Emma R Andersson
[1] Kimberly Foreman,et al. Notch-1 and Notch-4 Biomarker Expression in Triple-Negative Breast Cancer , 2012, International journal of surgical pathology.
[2] John J Dunn,et al. Distinct p53 genomic binding patterns in normal and cancer-derived human cells , 2011, Cell cycle.
[3] Pauliina Kronqvist,et al. Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms , 2011, Proceedings of the National Academy of Sciences.
[4] A. Chinnaiyan,et al. Functionally Recurrent Rearrangements of the MAST Kinase and Notch Gene Families in Breast Cancer , 2011, Nature Medicine.
[5] T. Palaga,et al. Direct regulation of interleukin-6 expression by Notch signaling in macrophages , 2011, Cellular and Molecular Immunology.
[6] Sumit K. Chanda,et al. Tumor suppressor protein (p)53, is a regulator of NF-κB repression by the glucocorticoid receptor , 2011, Proceedings of the National Academy of Sciences.
[7] Rickard Sandberg,et al. Notch signaling: simplicity in design, versatility in function , 2011, Development.
[8] S. Ghosh,et al. Crosstalk in NF-κB signaling pathways , 2011, Nature Immunology.
[9] Robert J. Lake,et al. Trp53 regulates Notch 4 signaling through Mdm2 , 2011, Journal of Cell Science.
[10] Israel Steinfeld,et al. miRNA-mRNA Integrated Analysis Reveals Roles for miRNAs in Primary Breast Tumors , 2011, PloS one.
[11] Yibin Kang,et al. Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. , 2011, Cancer cell.
[12] D. J. Jerry,et al. Repression of Mammary Stem/Progenitor Cells by p53 Is Mediated by Notch and Separable from Apoptotic Activity , 2011, Stem cells.
[13] A. Mantovani,et al. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm , 2010, Nature Immunology.
[14] A. Levine,et al. p53 and NF‐κB: different strategies for responding to stress lead to a functional antagonism , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[15] M. Zenke,et al. Activated Notch1 Target Genes during Embryonic Cell Differentiation Depend on the Cellular Context and Include Lineage Determinants and Inhibitors , 2010, PloS one.
[16] U. Lendahl,et al. Interactions between Notch- and hypoxia-induced transcriptomes in embryonic stem cells. , 2010, Experimental Cell Research.
[17] L. R. Perumalsamy,et al. Notch-activated signaling cascade interacts with mitochondrial remodeling proteins to regulate cell survival , 2010, Proceedings of the National Academy of Sciences of the United States of America.
[18] Hua Yu,et al. STATs in cancer inflammation and immunity: a leading role for STAT3 , 2009, Nature Reviews Cancer.
[19] Maija Wolf,et al. Data integration from two microarray platforms identifies bi-allelic genetic inactivation of RIC8A in a breast cancer cell line , 2009, BMC Medical Genomics.
[20] Raphael Kopan,et al. The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism , 2009, Cell.
[21] D. Johnston,et al. TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent. , 2009, Gene.
[22] L. R. Perumalsamy,et al. A hierarchical cascade activated by non-canonical Notch signaling and the mTOR–Rictor complex regulates neglect-induced death in mammalian cells , 2009, Cell Death and Differentiation.
[23] L. Strizzi,et al. Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis , 2009, Oncogene.
[24] U. Lendahl,et al. Notch-1 associates with IKKα and regulates IKK activity in cervical cancer cells , 2008, Oncogene.
[25] J. Royds,et al. Enhanced anti‐cancer effect of a phosphatidylinositol‐3 kinase inhibitor and doxorubicin on human breast epithelial cell lines with different p53 and oestrogen receptor status , 2008, International journal of cancer.
[26] J. Astola,et al. Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues , 2008, Genome Biology.
[27] Yuan Zhang,et al. Tumor-induced suppressor of cytokine signaling 3 inhibits toll-like receptor 3 signaling in dendritic cells via binding to tyrosine kinase 2. , 2008, Cancer research.
[28] Chindo Hicks,et al. Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. , 2008, Cancer research.
[29] U. Lendahl,et al. Notch signaling mediates hypoxia-induced tumor cell migration and invasion , 2008, Proceedings of the National Academy of Sciences.
[30] D. Santini,et al. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. , 2007, The Journal of clinical investigation.
[31] Karen H. Vousden,et al. p53 in health and disease , 2007, Nature Reviews Molecular Cell Biology.
[32] U. Lendahl,et al. High levels of Notch signaling down-regulate Numb and Numblike , 2006, The Journal of cell biology.
[33] P. M. Nissom,et al. A novel normalization method for effective removal of systematic variation in microarray data , 2006, Nucleic acids research.
[34] R. Clarke,et al. Aberrant Activation of Notch Signaling in Human Breast Cancer , 2006 .
[35] U. Lendahl,et al. Hypoxia requires notch signaling to maintain the undifferentiated cell state. , 2005, Developmental cell.
[36] L. Holmberg,et al. Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts , 2005, Breast Cancer Research.
[37] G. Lockwood,et al. High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. , 2005, Cancer research.
[38] P. Hall,et al. An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[39] J. Foekens,et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer , 2005, The Lancet.
[40] James F. Callahan,et al. Attenuation of Murine Collagen-Induced Arthritis by a Novel, Potent, Selective Small Molecule Inhibitor of IκB Kinase 2, TPCA-1 (2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), Occurs via Reduction of Proinflammatory Cytokines and Antigen-Induced T Cell Proliferation , 2005, Journal of Pharmacology and Experimental Therapeutics.
[41] Patrick Maisonneuve,et al. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis , 2004, The Journal of cell biology.
[42] J. Turkson,et al. STAT proteins as novel targets for cancer drug discovery , 2004, Expert opinion on therapeutic targets.
[43] P. Allavena,et al. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. , 2002, Trends in immunology.
[44] T. Schroeder,et al. Notch signalling via RBP‐J promotes myeloid differentiation , 2000, The EMBO journal.
[45] K. Wiman,et al. Reactivation of Mutant p53 through Interaction of a C-Terminal Peptide with the Core Domain , 1999, Molecular and Cellular Biology.
[46] G. Haegeman,et al. p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor* , 1998, The Journal of Biological Chemistry.
[47] T. Honjo,et al. Site-directed mutagenesis study on DNA binding regions of the mouse homologue of Suppressor of Hairless, RBP-Jx , 1994 .
[48] M. Roizen,et al. Hallmarks of Cancer: The Next Generation , 2012 .
[49] G. Schneider,et al. NFκB/p53 crosstalk-a promising new therapeutic target. , 2011, Biochimica et biophysica acta.
[50] S. Blacklow,et al. Mechanistic insights into Notch receptor signaling from structural and biochemical studies. , 2010, Current topics in developmental biology.
[51] P. Heitzler. Biodiversity and noncanonical Notch signaling. , 2010, Current topics in developmental biology.
[52] T. Golde,et al. Off the beaten pathway: the complex cross talk between Notch and NF-kappaB. , 2008, Laboratory investigation; a journal of technical methods and pathology.
[53] T. Golde,et al. Off the beaten pathway: the complex cross talk between Notch and NF-κB , 2008, Laboratory Investigation.
[54] Malay Mandal,et al. Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. , 2007, Nature medicine.
[55] Malay Mandal,et al. Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia , 2007, Nature Medicine.
[56] T. Honjo,et al. Site-directed mutagenesis study on DNA binding regions of the mouse homologue of Suppressor of Hairless, RBP-J kappa. , 1994, Nucleic acids research.