Activation of mouse bronchopulmonary C‐fibres by serotonin and allergen‐ovalbumin challenge

•  Mast cell‐derived serotonin is a principal mediator of allergic reactions in rodents. Serotonin can also be released from platelets during various pathological conditions. •  Vagal C‐fibres innervating the respiratory tract can be subdivided into nodose (placodal) C‐fibres or jugular (neural crest) C‐fibres). Activation of vagal placodal and/or neural crest vagal C‐fibres probably contributes to the dyspnoea, cough and reflex parasympathetic drive commonly associated with serotonin. •  Serotonin used different receptor subtypes to evoke strong action potential discharge in placodal (5‐HT3 receptors) versus neural crest (non‐5‐HT3 receptors)‐derived vagal C‐fibres in the mouse lung. •  Mast cell derived serotonin may activate neural crest C‐fibres, but did not stimulate placodal C‐fibres. •  The effect of extracellular serotonin on vagal afferent activation therefore depends on its cellular source and the C‐fibre phenotype.

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