Large‐Scale Synthesis of Bi2S3 Nanodots as a Contrast Agent for In Vivo X‐ray Computed Tomography Imaging

A facile strategy for the large-scale fabrication of Bi(2)S(3) nanodots is presented. Surface modification and control over the size of the nanodots is easily achieved. The as-prepared hydrophilic Bi(2)S(3) nanodots exhibit long in vivo circulation time and, more significantly, a contrast efficacy higher than that of the clinical iodinate agent without any adverse effect.

[1]  Jan Grimm,et al.  An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles , 2006, Nature materials.

[2]  M. El-Sayed,et al.  Wavelength-dependent hot electron relaxation in PVP capped CdS/HgS/CdS quantum dot quantum well nanocrystals , 2004 .

[3]  W. Kalender.  X-ray computed tomography , 2006, Physics in medicine and biology.

[4]  Guohua Cao,et al.  Iodinated nanoscale coordination polymers as potential contrast agents for computed tomography. , 2009, Angewandte Chemie.

[5]  Zahi A Fayad,et al.  Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography , 2007, Nature Medicine.

[6]  Hongyuan Chen,et al.  Photochemical synthesis of Bi2S3 nanoflowers on an alumina template , 2004 .

[7]  Hatem Fessi,et al.  Elaboration of radiopaque iodinated nanoparticles for in situ control of local drug delivery. , 2009, Biomaterials.

[8]  Jie Yin,et al.  Preparation of Bi2S3 nanowhiskers and their morphologies , 2003 .

[9]  Raoul Kopelman,et al.  Targeted gold nanoparticles enable molecular CT imaging of cancer. , 2008, Nano letters.

[10]  Samuel A Wickline,et al.  Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle. , 2009, Journal of the American Chemical Society.

[11]  Younan Xia,et al.  Shape-Controlled Synthesis of Gold and Silver Nanoparticles , 2002, Science.

[12]  Chenjie Xu,et al.  Size and Concentration Effect of Gold Nanoparticles on X-ray Attenuation As Measured on Computed Tomography. , 2008, Chemistry of materials : a publication of the American Chemical Society.

[13]  L. Cademartiri,et al.  Shape‐Controlled Bi2S3 Nanocrystals and Their Plasma Polymerization into Flexible Films , 2006 .

[14]  Yinjuan Xie,et al.  Biomolecule-assisted synthesis and electrochemical hydrogen storage of Bi2S3 flowerlike patterns with well-aligned nanorods. , 2006, The journal of physical chemistry. B.

[15]  Christlieb Haller,et al.  The Cytotoxicity of Iodinated Radiocontrast Agents on Renal Cells In Vitro , 2004, Investigative radiology.

[16]  J. Schlomka,et al.  Computed tomography in color: NanoK-enhanced spectral CT molecular imaging. , 2010, Angewandte Chemie.

[17]  Francis Vocanson,et al.  Gadolinium chelate coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging. , 2008, Journal of the American Chemical Society.

[18]  Sangjin Park,et al.  Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo X-ray computed tomography imaging. , 2007 .

[19]  I. Hizoh,et al.  Radiocontrast-Induced Renal Tubular Cell Apoptosis: Hypertonic Versus Oxidative Stress , 2002, Investigative radiology.

[20]  P. Fitzgerald,et al.  Synthesis, characterization, and computed tomography imaging of a tantalum oxide nanoparticle imaging agent. , 2010, Chemical communications.

[21]  Dar-Bin Shieh,et al.  In vitro and in vivo studies of FePt nanoparticles for dual modal CT/MRI molecular imaging. , 2010, Journal of the American Chemical Society.

[22]  J A Rowlands,et al.  Towards new functional nanostructures for medical imaging. , 2008, Medical physics.

[23]  Samuel Woojoo Jun,et al.  Large-scale synthesis of bioinert tantalum oxide nanoparticles for X-ray computed tomography imaging and bimodal image-guided sentinel lymph node mapping. , 2011, Journal of the American Chemical Society.

[24]  Xinggui Zhou,et al.  Bi2S3 nanostructures: A new photocatalyst , 2010 .

[25]  L. Cademartiri,et al.  Large-scale synthesis of ultrathin Bi2S3 necklace nanowires. , 2008, Angewandte Chemie.

[26]  Klaas Nicolay,et al.  Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents. , 2010, Biomaterials.

[27]  Baohua Zhang,et al.  Gd(III) functionalized gold nanorods for multimodal imaging applications. , 2011, Nanoscale.

[28]  H. Zentgraf,et al.  Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice. , 2010, Nano letters.

[29]  Xiangyang Ma,et al.  Long Bi2S3 nanowires prepared by a simple hydrothermal method , 2003 .

[30]  B. Korgel,et al.  Solventless Synthesis of Bi2S3 (Bismuthinite) Nanorods, Nanowires, and Nanofabric , 2005 .

[31]  Lehui Lu,et al.  Fluorescence-enhanced gadolinium-doped zinc oxide quantum dots for magnetic resonance and fluorescence imaging. , 2011, Biomaterials.

[32]  T. Tanaka,et al.  Size Control of Monodispersed Pt Nanoparticles and Their 2D Organization by Electrophoretic Deposition , 1999 .