Potential for MERLIN-Expo, an advanced tool for higher tier exposure assessment, within the EU chemical legislative frameworks.

MERLIN-Expo merges and integrates advanced exposure assessment methodologies, allowing the building of complex scenarios involving several pollution sources and targets. The assessment of exposure and risks to human health from chemicals is of major concern for policy and ultimately benefits all citizens. The development and operational fusion of the advanced exposure assessment methodologies envisaged in the MERLIN-Expo tool will have a significant impact in the long term on several policies dealing with chemical safety management. There are more than 30 agencies in Europe related to exposure and risk evaluation of chemicals, which have an important role in implementing EU policies, having especially tasks of technical, scientific, operational and/or regulatory nature. The main purpose of the present paper is to introduce MERLIN-Expo and to highlight its potential for being effectively integrated within the group of tools available to assess the risk and exposure of chemicals for EU policy. The main results show that the tool is highly suitable for use in site-specific or local impact assessment, with minor modifications it can also be used for Plant Protection Products (PPPs), biocides and REACH, while major additions would be required for a comprehensive application in the field of consumer and worker exposure assessment.

[1]  T De Wilde,et al.  Modelling the exposure to chemicals for risk assessment: a comprehensive library of multimedia and PBPK models for integration, prediction, uncertainty and sensitivity analysis - the MERLIN-Expo tool. , 2016, The Science of the total environment.

[2]  Philippe Verger,et al.  Combining analytical techniques, exposure assessment and biological effects for risk assessment of chemicals in food , 2009 .

[3]  J. Schlatter,et al.  Risk assessment of carcinogens in food. , 2010, Toxicology and applied pharmacology.

[4]  Antonio Marcomini,et al.  Modelling ecological and human exposure to POPs in Venice lagoon. Part I - Application of MERLIN-Expo tool for integrated exposure assessment. , 2016, The Science of the total environment.

[5]  Antonio Marcomini,et al.  Modelling ecological and human exposure to POPs in Venice lagoon - Part II: Quantitative uncertainty and sensitivity analysis in coupled exposure models. , 2016, The Science of the total environment.

[6]  Tim Hogg,et al.  Exposure assessment of chemicals from packaging materials in foods: a review , 2007 .

[7]  A. Standaert,et al.  Assessing multimedia/multipathway exposures to inorganic arsenic at population and individual level using MERLIN-Expo. , 2016, The Science of the total environment.

[8]  Philippe Ciffroy,et al.  Multimedia & PBPK modelling with MERLIN-Expo versus biomonitoring for assessing Pb exposure of pre-school children in a residential setting. , 2016, The Science of the total environment.

[9]  P Ciffroy,et al.  Development of a standard documentation protocol for communicating exposure models. , 2016, The Science of the total environment.