Window of opportunity: Estrogen as a treatment for ischemic stroke

[1]  F. Sohrabji,et al.  Revisiting the timing hypothesis: Biomarkers that define the therapeutic window of estrogen for stroke , 2013, Hormones and Behavior.

[2]  Andre Obenaus,et al.  The vascular neural network—a new paradigm in stroke pathophysiology , 2012, Nature Reviews Neurology.

[3]  C. Rosen,et al.  Worsened outcome from middle cerebral artery occlusion in aged rats receiving 17β-estradiol. , 2012, Endocrinology.

[4]  Shao-Hua Yang,et al.  Transient Focal Cerebral Ischemia Induces Long-term Cerebral Vasculature Dysfunction in a Rodent Experimental Stroke Model , 2012, Translational Stroke Research.

[5]  Peter J. Schmidt,et al.  The 2022 hormone therapy position statement of The North American Menopause Society , 2022, Menopause.

[6]  F. Sohrabji,et al.  An Antagomir to MicroRNA Let7f Promotes Neuroprotection in an Ischemic Stroke Model , 2012, PloS one.

[7]  R. Vadlamudi,et al.  Estrogen neuroprotection and the critical period hypothesis , 2012, Frontiers in Neuroendocrinology.

[8]  F. Sohrabji,et al.  Reproductive age modulates the impact of focal ischemia on the forebrain as well as the effects of estrogen treatment in female rats , 2010, Neurobiology of Aging.

[9]  F. Sohrabji,et al.  The Neurotoxic Effects of Estrogen on Ischemic Stroke in Older Female Rats Is Associated with Age-Dependent Loss of Insulin-Like Growth Factor-1 , 2010, The Journal of Neuroscience.

[10]  J. Simpkins,et al.  Combination Therapy of 17β-Estradiol and Recombinant Tissue Plasminogen Activator for Experimental Ischemic Stroke , 2010, Journal of Pharmacology and Experimental Therapeutics.

[11]  S. Resnick,et al.  Postmenopausal hormone therapy and cognitive outcomes: The Women's Health Initiative Memory Study (WHIMS) , 2010, The Journal of Steroid Biochemistry and Molecular Biology.

[12]  B. Sherwin.  Estrogen therapy: is time of initiation critical for neuroprotection? , 2009, Nature Reviews Endocrinology.

[13]  E. Banks,et al.  Invited Commentary: Hormone therapy risks and benefits--The Women's Health Initiative findings and the postmenopausal estrogen timing hypothesis. , 2009, American Journal of Epidemiology.

[14]  Lewis H Kuller,et al.  Benefits and risks of postmenopausal hormone therapy when it is initiated soon after menopause. , 2009, American journal of epidemiology.

[15]  L. McCullough,et al.  Sex Differences in Stroke , 2008, Cerebrovascular Diseases.

[16]  P. Čičovački.  SOCIETY , 2008, Society.

[17]  E. Barrett-Connor.  Hormones and heart disease in women: the timing hypothesis. , 2007, American journal of epidemiology.

[18]  C. Justicia,et al.  Transient middle cerebral artery occlusion causes different structural, mechanical, and myogenic alterations in normotensive and hypertensive rats. , 2007, American journal of physiology. Heart and circulatory physiology.

[19]  K. Furie,et al.  Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. , 2007, Circulation.

[20]  J. Álvarez-Sabín,et al.  Risk of ischemic stroke and lifetime estrogen exposure , 2007, Neurology.

[21]  J. Buring,et al.  Effects of Conjugated Equine Estrogen on Stroke in the Women’s Health Initiative , 2006, Circulation.

[22]  P. Maki.  Hormone therapy and cognitive function: Is there a critical period for benefit? , 2006, Neuroscience.

[23]  J. Simpkins,et al.  17β-Estradiol attenuates blood–brain barrier disruption induced by cerebral ischemia–reperfusion injury in female rats , 2005, Brain Research.

[24]  W. Ouwehand,et al.  The FASEB Journal • Research Communication Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI , 2022 .

[25]  J. Simpkins,et al.  Estrogens as protectants of the neurovascular unit against ischemic stroke. , 2005, Current drug targets. CNS and neurological disorders.

[26]  K. Koh,et al.  Should progestins be blamed for the failure of hormone replacement therapy to reduce cardiovascular events in randomized controlled trials? , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[27]  JoAnn E Manson,et al.  Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study. , 2004, JAMA.

[28]  J. Merrill,et al.  17beta‐estradiol protects oligodendrocytes from cytotoxicity induced cell death , 2004, Journal of neurochemistry.

[29]  R. Graf,et al.  Cerebral Ischemia and Reperfusion: The Pathophysiologic Concept as a Basis for Clinical Therapy , 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[30]  Scott Hamilton,et al.  Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials , 2004, The Lancet.

[31]  David I. Graham,et al.  Differential Effects of 17β-Estradiol upon Stroke Damage in Stroke Prone and Normotensive Rats , 2004 .

[32]  M. Moskowitz,et al.  tPA and proteolysis in the neurovascular unit. , 2004, Stroke.

[33]  J. Simpkins,et al.  The Use of Estrogens and Related Compounds in the Treatment of Damage from Cerebral Ischemia , 2003, Annals of the New York Academy of Sciences.

[34]  G. Rosenberg,et al.  Closure of the Blood-Brain Barrier by Matrix Metalloproteinase Inhibition Reduces rtPA-Mediated Mortality in Cerebral Ischemia With Delayed Reperfusion , 2003, Stroke.

[35]  L. McCullough,et al.  Estrogen and ischemic neuroprotection: an integrated view , 2003, Trends in Endocrinology & Metabolism.

[36]  J. M. Wardlaw,et al.  Thrombolytic Therapy With Recombinant Tissue Plasminogen Activator for Acute Ischemic Stroke: Where Do We Go From Here? A Cumulative Meta-Analysis , 2003, Stroke.

[37]  C. Kooperberg,et al.  Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trial. , 2003, JAMA.

[38]  C. Kluft,et al.  The effect of 17β-oestradiol on variables of coagulation and fibrinolysis in postmenopausal women with type 2 diabetes mellitus , 2002 .

[39]  M. Cipolla,et al.  Middle Cerebral Artery Function After Stroke: The Threshold Duration of Reperfusion for Myogenic Activity , 2002, Stroke.

[40]  R. Gillum.  New Considerations in Analyzing Stroke and Heart Disease Mortality Trends: The Year 2000 Age Standard and the International Statistical Classification of Diseases and Related Health Problems, 10th Revision , 2002, Stroke.

[41]  Brett C Meyer,et al.  Modified National Institutes of Health Stroke Scale for Use in Stroke Clinical Trials: Prospective Reliability and Validity , 2002, Stroke.

[42]  E. Lo,et al.  Involvement of Matrix Metalloproteinase in Thrombolysis-Associated Hemorrhagic Transformation After Embolic Focal Ischemia in Rats , 2002, Stroke.

[43]  M. Woodward,et al.  Hormonal replacement therapy, prothrombotic mutations and the risk of venous thrombosis , 2002, British journal of haematology.

[44]  P. Wise,et al.  Estradiol is a protective factor in the adult and aging brain: understanding of mechanisms derived from in vivo and in vitro studies , 2001, Brain Research Reviews.

[45]  C. Viscoli,et al.  A clinical trial of estrogen-replacement therapy after ischemic stroke. , 2001, The New England journal of medicine.

[46]  J. Grotta.  Combination Therapy Stroke Trial , 2001, Annals of the New York Academy of Sciences.

[47]  Hao Jiang,et al.  17&bgr;-Estradiol Protects Neurons from Ischemic Damage and Attenuates Accumulation of Extracellular Excitatory Amino Acids , 2001 .

[48]  P D Lyden,et al.  A Modified National Institutes of Health Stroke Scale for Use in Stroke Clinical Trials: Preliminary Reliability and Validity , 2001, Stroke.

[49]  O. Gratzl,et al.  17β-Estradiol reduces cortical lesion size in the glutamate excitotoxicity model by enhancing extracellular lactate: a new neuroprotective pathway , 2001, Brain Research.

[50]  Izumi Harukuni,et al.  Deleterious effect of β-estradiol in a rat model of transient forebrain ischemia , 2001, Brain Research.

[51]  L. McCullough,et al.  Postischemic Estrogen Reduces Hypoperfusion and Secondary Ischemia After Experimental Stroke , 2001, Stroke.

[52]  J. Hsia,et al.  Postmenopausal Hormone Therapy and Risk of Stroke: The Heart and Estrogen-progestin Replacement Study (HERS) , 2001, Circulation.

[53]  W. Millard,et al.  17-β Estradiol Can Reduce Secondary Ischemic Damage and Mortality of Subarachnoid Hemorrhage , 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[54]  R. Traystman,et al.  Estrogen Decreases Infarct Size After Temporary Focal Ischemia in a Genetic Model of Type 1 Diabetes Mellitus , 2000, Stroke.

[55]  A. Dominiczak,et al.  Investigation of Estrogen Status and Increased Stroke Sensitivity on Cerebral Blood Flow after a Focal Ischemic Insult , 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[56]  A. Shuaib,et al.  Enhanced neuroprotection and reduced hemorrhagic incidence in focal cerebral ischemia of rat by low dose combination therapy of urokinase and topiramate , 2000, Neuropharmacology.

[57]  E. Lo,et al.  Reduction of Tissue Plasminogen Activator-Induced Hemorrhage and Brain Injury by Free Radical Spin Trapping after Embolic Focal Cerebral Ischemia in Rats , 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[58]  J. Shi,et al.  Estradiol exerts neuroprotective effects when administered after ischemic insult. , 2000, Stroke.

[59]  C. Culmsee,et al.  Neuroprotection by Estrogens in a Mouse Model of Focal Cerebral Ischemia and in Cultured Neurons: Evidence for a Receptor-Independent Antioxidative Mechanism , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[60]  T. Horvath,et al.  Estrogen and microglia: A regulatory system that affects the brain. , 1999, Journal of neurobiology.

[61]  L. Garcia-Segura,et al.  Role of astroglia in estrogen regulation of synaptic plasticity and brain repair. , 1999, Journal of neurobiology.

[62]  G. Boysen,et al.  Effects of citicoline combined with thrombolytic therapy in a rat embolic stroke model. , 1999, Stroke.

[63]  S. Finklestein,et al.  Estradiol Protects against Ischemic Injury , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[64]  R. Traystman,et al.  Estrogen-mediated neuroprotection after experimental stroke in male rats. , 1998, Stroke.

[65]  D. Krause,et al.  Estrogen reduces myogenic tone through a nitric oxide-dependent mechanism in rat cerebral arteries. , 1998, American journal of physiology. Heart and circulatory physiology.

[66]  A. Day,et al.  Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male rats , 1998, Brain Research.

[67]  J. Weir,et al.  Estrogen replacement, vascular distensibility, and blood pressures in postmenopausal women. , 1998, American journal of physiology. Heart and circulatory physiology.

[68]  M. Sakanaka,et al.  β-Estradiol protects hippocampal CA1 neurons against transient forebrain ischemia in gerbil , 1997, Neuroscience Research.

[69]  Y Q Zhang,et al.  Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. , 1997, Journal of neurosurgery.

[70]  I. Laher,et al.  Estrogen regulates myogenic tone in pressurized cerebral arteries by enhanced basal release of nitric oxide. , 1997, The American journal of physiology.

[71]  R. Rothlein,et al.  Monoclonal antibodies preventing leukocyte activation reduce experimental neurologic injury and enhance efficacy of thrombolytic therapy , 1995, Neurology.

[72]  J. Simpkins,et al.  Estradiol Treatment Increases Viability of Glioma and Neuroblastoma Cells in Vitro , 1994, Molecular and Cellular Neuroscience.

[73]  X. Jouven,et al.  Early Carotid Atherosclerosis in Healthy Middle‐Aged Women: A Follow‐up Study , 1993, Stroke.

[74]  G. Boysen,et al.  Enhancing the efficacy of thrombolysis by AMPA receptor blockade with NBQX in a rat embolic stroke model , 1993, Journal of the Neurological Sciences.

[75]  J. Zivin,et al.  Tissue plasminogen activator plus glutamate antagonist improves outcome after embolic stroke. , 1991, Archives of neurology.

[76]  E. Hall,et al.  Sex Differences in Postischemic Neuronal Necrosis in Gerbils , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[77]  Richard L. Abbott,et al.  A Follow-up Study , 1990 .

[78]  E. A. Doisy,et al.  THE PREPARATION OF THE CRYSTALLINE OVARIAN HORMONE FROM THE URINE OF PREGNANT WOMEN , 1930 .

[79]  R. Frank,et al.  DEMONSTRATION OF THE FEMALE SEX HORMONE IN THE CIRCULATING BLOOD: I. PRELIMINARY REPORT , 1925 .

[80]  G. Zoppo.  Toward the Neurovascular Unit A Journey in Clinical Translation 2012 Thomas Willis Lecture , 2013 .

[81]  D. Graham,et al.  Differential effects of 17beta-estradiol upon stroke damage in stroke prone and normotensive rats. , 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[82]  J. Mohr,et al.  Ischemic stroke therapy. , 2002, Annual review of medicine.

[83]  C. Kluft,et al.  The effect of 17 beta-oestradiol on variables of coagulation and fibrinolysis in postmenopausal women with type 2 diabetes mellitus. , 2002, Vascular pharmacology.

[84]  B. Crain,et al.  Deleterious effect of beta-estradiol in a rat model of transient forebrain ischemia. , 2001, Brain research.

[85]  W. Xu,et al.  17 beta-estradiol protects neurons from ischemic damage and attenuates accumulation of extracellular excitatory amino acids. , 2001, Anesthesia and analgesia.

[86]  S. Ibayashi,et al.  Ovariectomy exacerbates and estrogen replacement attenuates photothrombotic focal ischemic brain injury in rats. , 2000, Stroke.

[87]  E. Metter,et al.  Influence of age and postmenopausal estrogen replacement therapy on carotid arterial stiffness in women. , 1999, Cardiovascular research.

[88]  R. Traystman,et al.  Gender-linked brain injury in experimental stroke. , 1998, Stroke.

[89]  A. McCall,et al.  Reperfusion decreases myogenic reactivity and alters middle cerebral artery function after focal cerebral ischemia in rats. , 1997, Stroke.