Electricity and Magnetism at the Cellular Level

This chapter describes a number of topics related to charged membranes and the movement of ions through them, including Donnan equilibrium, the Gouy–Chapman model, and the Nernst–Planck equation. Ions in solution are analyzed using the Debye–Huckel model and the Poisson–Boltzmann equation. Membrane ion channels are then discussed, with an emphasis on the potassium ion channel structure and function. Patch clamp methods can be used to measure the electrical current through individual channels, but noise in these measurements often obscures the signal. The chapter ends with a review of the possible effects of weak electric and magnetic fields on the body.

[1]  C. Polk,et al.  Effects of extremely-low-frequency magnetic fields on biological magnetite. , 1994, Bioelectromagnetics.

[2]  H. Maciel,et al.  Physics and Biology: Bio-plasma physics , 2000 .

[3]  Kenneth R. Foster,et al.  Wi-Fi and Health: Review of Current Status of Research , 2013, Health physics.

[4]  Electromagnetic field effects and mechanisms , 1996 .

[5]  A. Hodgkin,et al.  The effect of changing the internal solution on sodium inactivation and related phenomena in giant axons. , 1965, The Journal of physiology.

[6]  K. Magleby,et al.  Single channel recordings of Ca2+-activated K+ currents in rat muscle cell culture , 1981, Nature.

[7]  B. Sakmann,et al.  Single-channel currents recorded from membrane of denervated frog muscle fibres , 1976, Nature.

[8]  C. Nichols,et al.  Inward rectification and implications for cardiac excitability. , 1996, Circulation research.

[9]  Stephen D. Smith Possible health effects of exposure to residential electric and magnetic fields , 1997 .

[10]  Webb,et al.  Thermal-noise-limited transduction observed in mechanosensory receptors of the inner ear. , 1989, Physical review letters.

[11]  J. Kirschvink,et al.  Comment on "Constraints on biological effects of weak extremely-low-frequency electromagnetic fields" , 1992, Physical review. A, Atomic, molecular, and optical physics.

[12]  Adair Reply to "Comment on 'Constraints on biological effects of weak extremely-low-frequency electromagnetic fields' " , 1992, Physical review. A, Atomic, molecular, and optical physics.

[13]  Jelle Atema,et al.  Sensory Biology of Aquatic Animals , 1988, Springer New York.

[14]  E. L. Carstensen Magnetic fields and cancer , 1995 .

[15]  R. Adair,et al.  Constraints of thermal noise on the effects of weak 60-Hz magnetic fields acting on biological magnetite. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[16]  J E Moulder,et al.  Biological Effects of Power-Frequency Fields As They Relate to Carcinogenesis , 1995, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[17]  Milton Abramowitz,et al.  Handbook of Mathematical Functions with Formulas, Graphs, and Mathematical Tables , 1964 .

[18]  A. Mauro,et al.  Space Charge Regions in Fixed Charge Membranes and the Associated Property of Capacitance. , 1962, Biophysical journal.

[19]  S. Bren 60 Hz EMF health effects-a scientific uncertainty , 1995 .

[20]  Adair,et al.  Constraints on biological effects of weak extremely-low-frequency electromagnetic fields. , 1991, Physical review. A, Atomic, molecular, and optical physics.

[21]  R. Astumian,et al.  The response of living cells to very weak electric fields: the thermal noise limit. , 1990, Science.

[22]  K.R. Foster,et al.  Is there a link between exposure to power frequency electric fields and cancer? , 1999, IEEE Engineering in Medicine and Biology Magazine.

[23]  R. Keynes The kinetics of voltage-gated ion channels , 1994, Quarterly Reviews of Biophysics.

[24]  Shin-Ho Chung,et al.  Tests of continuum theories as models of ion channels. II. Poisson-Nernst-Planck theory versus brownian dynamics. , 2000, Biophysical journal.

[25]  J. Kirschvink,et al.  Magnetite biomineralization in the human brain. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[26]  J E Moulder,et al.  Mobile phones, mobile phone base stations and cancer: a review , 2005, International journal of radiation biology.

[27]  C A Lewis,et al.  Ion‐concentration dependence of the reversal potential and the single channel conductance of ion channels at the frog neuromuscular junction. , 1979, The Journal of physiology.

[28]  A. Pais Einstein and the Press , 1994 .

[29]  T. Tenforde Spectrum and Intensity of Environmental Electromagnetic Fields from Natural and Man-Made Sources , 1995 .

[30]  K. S. Kölbig,et al.  Errata: Milton Abramowitz and Irene A. Stegun, editors, Handbook of Mathematical Functions with Formulas, Graphs, and Mathematical Tables, National Bureau of Standards, Applied Mathematics Series, No. 55, U.S. Government Printing Office, Washington, D.C., 1994, and all known reprints , 1972 .

[31]  R. Adair Effects of ELF magnetic fields on biological magnetite. , 1993, Bioelectromagnetics.

[32]  Quirino Balzano,et al.  QUANTITATIVE EVALUATIONS OF MECHANISMS OF RADIOFREQUENCY INTERACTIONS WITH BIOLOGICAL MOLECULES AND PROCESSES , 2008, Health physics.

[33]  F. Sigworth,et al.  Fluctuations in ion channel gating currents. Analysis of nonstationary shot noise. , 1993, Biophysical journal.

[34]  C. Orton,et al.  There is currently enough evidence and technology available to warrant taking immediate steps to reduce exposure of consumers to cell-phone-related electromagnetic radiation. , 2008, Medical physics.

[35]  Joseph L. Kirschvink,et al.  Ferromagnetism and EMFs , 1995, Nature.

[36]  Charles Polk,et al.  CRC Handbook of Biological Effects of Electromagnetic Fields , 1986 .

[37]  B. Sakmann,et al.  Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches , 1981, Pflügers Archiv.

[38]  M. Cadene,et al.  X-ray structure of a voltage-dependent K+ channel , 2003, Nature.

[39]  Martin Blank,et al.  Electromagnetic Fields: Biological Interactions and Mechanisms , 1995 .

[40]  Robert D. Tucker,et al.  Tests for Human Perception of 60 Hz Moderate Strength Magnetic Fields , 1978, IEEE Transactions on Biomedical Engineering.

[41]  Boris I Shklovskii,et al.  Colloquium: The physics of charge inversion in chemical and biological systems , 2002 .

[42]  James C. Weaver,et al.  Detection of weak electric fields by sharks, rays, and skates. , 1998, Chaos.

[43]  J. Swihart,et al.  Steady-state electrodiffusion. Scaling, exact solution for ions of one charge, and the phase plane. , 1977, Biophysical journal.

[44]  H. Nymeyer,et al.  Test of the Gouy-Chapman theory for a charged lipid membrane against explicit-solvent molecular dynamics simulations. , 2008, Physical review letters.

[45]  W. Catterall,et al.  THE CRYSTAL STRUCTURE OF A VOLTAGE-GATED SODIUM CHANNEL , 2011, Nature.

[46]  R. Mann,et al.  The role of DNA shape in protein-DNA recognition , 2009, Nature.

[47]  R. Astumian,et al.  Rectification and signal averaging of weak electric fields by biological cells. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[48]  Arijitt Borthakur,et al.  23Na MRI accurately measures fixed charge density in articular cartilage , 2002, Magnetic resonance in medicine.

[49]  W. Pickard,et al.  A model for the acute electrosensitivity of cartilaginous fishes , 1988, IEEE Transactions on Biomedical Engineering.

[50]  F J Sigworth,et al.  Voltage gating of ion channels , 1994, Quarterly Reviews of Biophysics.

[51]  Ad. J. Kalmijn,et al.  Detection of Weak Electric Fields , 1988 .

[52]  B. Chait,et al.  The structure of the potassium channel: molecular basis of K+ conduction and selectivity. , 1998, Science.

[53]  Louis J. DeFelice,et al.  Introduction to membrane noise , 1981 .

[54]  James C. Weaver,et al.  Electroporation of cells and tissues , 2000 .

[55]  B. Hille,et al.  Ionic channels of excitable membranes , 2001 .

[56]  R. Adair Static and low-frequency magnetic field effects: health risks and therapies , 2000 .

[57]  B. Honig,et al.  Classical electrostatics in biology and chemistry. , 1995, Science.

[58]  Kenneth R. Foster,et al.  Dielectric Properties of Tissues , 2008 .

[59]  H. M. Fishman,et al.  Interaction of apical and basal membrane ion channels underlies electroreception in ampullary epithelia of skates. , 1994, Biophysical journal.