Preferential localisation of red cell vacuoles to pathologically shaped human red blood cells

The percentage of pitted erythrocytes and Howell‐Jolly bodies in peripheral blood samples of 51 individuals following posttraumatic splenectomy and 20 patients splenectomized because of various haematological diseases differed significantly from each other (p < 0.001) and from that of healthy controls (p < 0.001). The percentage of pitted erythrocytes was significantly higher in pathologically shaped red blood cells (RBCs) (acanthocytes, schizocytes, elliptocytes) than in normal discoid shaped RBCs (p < 0.001). As the number of pits per RBC showed great individual variations, a scoring system for the evaluation of pitted RBCs is proposed.

[1]  W. Reinhart,et al.  Red cell vacuoles: Their size and distribution under normal conditions and after splenectomy , 1988, American journal of hematology.

[2]  C. Kuni,et al.  Splenic reticuloendothelial function after splenectomy, spleen repair, and spleen autotransplantation. , 1987, The New England journal of medicine.

[3]  G. Buchanan,et al.  Pocked erythrocyte counts in patients with hereditary spherocytosis before and after splenectomy , 1987, American journal of hematology.

[4]  B. Kvinesdal,et al.  Pitted erythrocytes in splenectomized subjects with congenital spherocytosis and in subjects splenectomized for other reasons. , 2009, Scandinavian journal of haematology.

[5]  M. Zago,et al.  Red cell pits appear preferentially in old cells after splenectomy. , 1986, Acta haematologica.

[6]  M. Espeland,et al.  Developmental pattern of splenic dysfunction in sickle cell disorders. , 1985, Pediatrics.

[7]  B. Murphy,et al.  ‘Pitted’ erythrocytes: impaired formation in splenectomized subjects with congenital spherocytosis , 1984, British Journal of Haematology.

[8]  J. L. Nielsen.  Influence of residual splenic tissue on the presence of vacuolated erythrocytes in splenectomized patients. , 2009, Scandinavian journal of haematology.

[9]  J. L. Nielsen,et al.  Detection of splenosis and ectopic spleens with 99mTc-labelled heat damaged autologous erythrocytes in 90 splenectomized patients. , 2009, Scandinavian journal of haematology.

[10]  P. D. James,et al.  ECTOPIC SPLENIC TISSUE FAILED TO PREVENT FATAL PNEUMOCOCCAL SEPTICÆMIA AFTER SPLENECTOMY FOR TRAUMA , 1980, The Lancet.

[11]  R. Touloukian,et al.  The born-again spleen. Return of splenic function after splenectomy for trauma. , 1978, The New England journal of medicine.

[12]  S. Koethe,et al.  A new method for studying splenic reticuloendothelial dysfunction in sickle cell disease patients and its clinical application: a brief report. , 1976, Blood.

[13]  F. Gardner,et al.  Acquisition of autophagic vacuoles by human erythrocytes. Physiological role of the spleen. , 1970, Blood.

[14]  R. Gunn,et al.  Thalassemia: the consequences of unbalanced hemoglobin synthesis. , 1966, The American journal of medicine.