Regulation of the osmoregulatory HOG MAPK cascade in yeast.

The budding yeast Saccharomyces cerevisiae has at least five signal pathways containing a MAP kinase (MAPK) cascade. The high osmolarity glycerol (HOG) MAPK pathway is essential for yeast survival in high osmolarity environment. This mini-review surveys recent developments in regulation of the HOG pathway with specific emphasis on the roles of protein phosphatases and protein subcellular localization. The Hog1 MAPK in the HOG pathway is negatively regulated jointly by the protein tyrosine phosphatases Ptp2/Ptp3 and the type 2 protein phosphatases Ptc1/Ptc2/Ptc3. Specificities of these phosphatases are determined by docking interactions as well as their cellular localizations. The subcellular localizations of the osmosensors (Sln1 and Sho1), kinases (Pbs2, Hog1), and phosphatases in the HOG pathway are intricately regulated to achieve their specific functions.

[1]  Ming-Ming Zhou,et al.  Structure and regulation of MAPK phosphatases. , 2004, Cellular signalling.

[2]  Reciprocal Regulation between Slt2 MAPK and Isoforms of Msg5 Dual-specificity Protein Phosphatase Modulates the Yeast Cell Integrity Pathway* , 2004, Journal of Biological Chemistry.

[3]  I. Ota,et al.  Nbp2 targets the Ptc1‐type 2C Ser/Thr phosphatase to the HOG MAPK pathway , 2004, The EMBO journal.

[4]  Eulàlia de Nadal,et al.  The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes , 2004, Nature.

[5]  T. Maeda,et al.  Phosphorelay-Regulated Degradation of the Yeast Ssk1p Response Regulator by the Ubiquitin-Proteasome System , 2003, Molecular and Cellular Biology.

[6]  Kazuo Tatebayashi,et al.  A docking site determining specificity of Pbs2 MAPKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway , 2003, The EMBO journal.

[7]  S. Hohmann,et al.  Combination of Two Activating Mutations in One HOG1 Gene Forms Hyperactive Enzymes That Induce Growth Arrest , 2003, Molecular and Cellular Biology.

[8]  D. Raitt,et al.  Yeast osmosensor Sln1 and plant cytokinin receptor Cre1 respond to changes in turgor pressure , 2003, The Journal of cell biology.

[9]  Eulàlia de Nadal,et al.  Osmostress‐induced transcription by Hot1 depends on a Hog1‐mediated recruitment of the RNA Pol II , 2003, The EMBO journal.

[10]  F. Posas,et al.  Targeting the MEF2-Like Transcription Factor Smp1 by the Stress-Activated Hog1 Mitogen-Activated Protein Kinase , 2003, Molecular and Cellular Biology.

[11]  H. Saito.  The Sln1-Ypd1-Ssk1 Multistep Phosphorelay System That Regulates an Osmosensing MAP Kinase Cascade in Yeast , 2003 .

[12]  Irene Ota,et al.  Role of Ptc2 Type 2C Ser/Thr Phosphatase in Yeast High-Osmolarity Glycerol Pathway Inactivation , 2002, Eukaryotic Cell.

[13]  K. Shiozaki,et al.  Cytoplasmic localization of Wis1 MAPKK by nuclear export signal is important for nuclear targeting of Spc1/Sty1 MAPK in fission yeast. , 2002, Molecular biology of the cell.

[14]  Ira Herskowitz,et al.  Yeast go the whole HOG for the hyperosmotic response. , 2002, Trends in genetics : TIG.

[15]  Eulàlia de Nadal,et al.  Dealing with osmostress through MAP kinase activation , 2002, EMBO reports.

[16]  J. Hahn,et al.  Regulation of the Saccharomyces cerevisiae Slt2 Kinase Pathway by the Stress-inducible Sdp1 Dual Specificity Phosphatase* , 2002, The Journal of Biological Chemistry.

[17]  K. Struhl,et al.  Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress. , 2002, Molecular cell.

[18]  S. Hohmann.  Osmotic Stress Signaling and Osmoadaptation in Yeasts , 2002, Microbiology and Molecular Biology Reviews.

[19]  N. Ogawa,et al.  A series of double disruptants for protein phosphatase genes in Saccharomyces cerevisiae and their phenotypic analysis , 2002, Yeast.

[20]  I. Ota,et al.  Heat Stress Activates the Yeast High-Osmolarity Glycerol Mitogen-Activated Protein Kinase Pathway, and Protein Tyrosine Phosphatases Are Essential under Heat Stress , 2002, Eukaryotic Cell.

[21]  H. Saito,et al.  Histidine phosphorylation and two-component signaling in eukaryotic cells. , 2001, Chemical reviews.

[22]  M Teige,et al.  Rck2, a member of the calmodulin-protein kinase family, links protein synthesis to high osmolarity MAP kinase signaling in budding yeast , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Irene Ota,et al.  Ptc1, a Type 2C Ser/Thr Phosphatase, Inactivates the HOG Pathway by Dephosphorylating the Mitogen-Activated Protein Kinase Hog1 , 2001, Molecular and Cellular Biology.

[24]  M. Tyers,et al.  Regulation of cell cycle progression by Swe1p and Hog1p following hypertonic stress. , 2001, Molecular biology of the cell.

[25]  A. West,et al.  Novel Role for an HPt Domain in Stabilizing the Phosphorylated State of a Response Regulator Domain , 2000, Journal of bacteriology.

[26]  D. Raitt,et al.  Yeast Cdc42 GTPase and Ste20 PAK‐like kinase regulate Sho1‐dependent activation of the Hog1 MAPK pathway , 2000, The EMBO journal.

[27]  Gustav Ammerer,et al.  Polarized localization of yeast Pbs2 depends on osmostress, the membrane protein Sho1 and Cdc42 , 2000, Nature Cell Biology.

[28]  M. Peter,et al.  Phosphorylation of the MEKK Ste11p by the PAK-like kinase Ste20p is required for MAP kinase signaling in vivo , 2000, Current Biology.

[29]  P. Sunnerhagen,et al.  Rck2 Kinase Is a Substrate for the Osmotic Stress-Activated Mitogen-Activated Protein Kinase Hog1 , 2000, Molecular and Cellular Biology.

[30]  I. Ota,et al.  Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast. , 2000, Genes & development.

[31]  J. Thevelein,et al.  The Transcriptional Response of Saccharomyces cerevisiae to Osmotic Shock , 2000, The Journal of Biological Chemistry.

[32]  P. Kaldis,et al.  Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. , 1999, Genes & development.

[33]  K. Guan,et al.  A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase. , 1999, Genes & development.

[34]  I. Ota,et al.  Differential Regulation of the Cell Wall Integrity Mitogen-Activated Protein Kinase Pathway in Budding Yeast by the Protein Tyrosine Phosphatases Ptp2 and Ptp3 , 1999, Molecular and Cellular Biology.

[35]  J. Thevelein,et al.  Osmotic Stress-Induced Gene Expression in Saccharomyces cerevisiae Requires Msn1p and the Novel Nuclear Factor Hot1p , 1999, Molecular and Cellular Biology.

[36]  K. Shiozaki,et al.  Heat-shock-induced activation of stress MAP kinase is regulated by threonine- and tyrosine-specific phosphatases. , 1999, Genes & development.

[37]  Michael Gurfinkel,et al.  Differential Stabilities of Phosphorylated Response Regulator Domains Reflect Functional Roles of the Yeast Osmoregulatory SLN1 and SSK1 Proteins , 1999, Journal of bacteriology.

[38]  R. Serrano,et al.  Repressors and Upstream Repressing Sequences of the Stress-Regulated ENA1 Gene in Saccharomyces cerevisiae: bZIP Protein Sko1p Confers HOG-Dependent Osmotic Regulation , 1999, Molecular and Cellular Biology.

[39]  Francesc Posas,et al.  Requirement of STE50 for Osmostress-Induced Activation of the STE11 Mitogen-Activated Protein Kinase Kinase Kinase in the High-Osmolarity Glycerol Response Pathway , 1998, Molecular and Cellular Biology.

[40]  Pamela A. Silver,et al.  Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin β homologs NMD5 and XPO1 , 1998, The EMBO journal.

[41]  F. Posas,et al.  Signal transduction by MAP kinase cascades in budding yeast. , 1998, Current opinion in microbiology.

[42]  I. Ota,et al.  Two Protein-tyrosine Phosphatases Inactivate the Osmotic Stress Response Pathway in Yeast by Targeting the Mitogen-activated Protein Kinase, Hog1* , 1997, The Journal of Biological Chemistry.

[43]  R. Deschenes,et al.  Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae. , 1997, Genes & development.

[44]  F. Posas,et al.  Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK. , 1997, Science.

[45]  H. Saito,et al.  Two-component signal transducers and MAPK cascades. , 1997, Trends in biochemical sciences.

[46]  T. Maeda,et al.  Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases , 1997, Molecular and cellular biology.

[47]  Francesc Posas,et al.  Yeast HOG1 MAP Kinase Cascade Is Regulated by a Multistep Phosphorelay Mechanism in the SLN1–YPD1–SSK1 “Two-Component” Osmosensor , 1996, Cell.

[48]  T. Maeda,et al.  Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. , 1995, Science.

[49]  Tatsuya Maeda,et al.  A two-component system that regulates an osmosensing MAP kinase cascade in yeast , 1994, Nature.

[50]  K. Matsumoto,et al.  MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae. , 1994, The EMBO journal.

[51]  T. Maeda,et al.  Mutations in a protein tyrosine phosphatase gene (PTP2) and a protein serine/threonine phosphatase gene (PTC1) cause a synthetic growth defect in Saccharomyces cerevisiae , 1993, Molecular and cellular biology.