Contextual determinants of TGFβ action in development, immunity and cancer
暂无分享,去创建一个
[1] M. Whitman,et al. A transcriptional partner for MAD proteins in TGF-beta signalling. , 1996, Nature.
[2] K. Miyazono,et al. Regulation of TGF-β Family Signaling by Inhibitory Smads. , 2017, Cold Spring Harbor perspectives in biology.
[3] Jeffrey L. Wrana,et al. Mechanism of activation of the TGF-β receptor , 1994, Nature.
[4] Paul Tempst,et al. Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. , 2009, Molecular cell.
[5] K. Miyazono,et al. Characterization of a bone morphogenetic protein-responsive Smad-binding element. , 2000, Molecular biology of the cell.
[6] J. Wolchok,et al. Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment , 2017, Science Signaling.
[7] A. Balmain,et al. Metastasis is driven by sequential elevation of H-ras and Smad2 levels , 2002, Nature Cell Biology.
[8] J. Massagué,et al. TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. , 2005, Cancer cell.
[9] A. Donovan,et al. Blocking extracellular activation of myostatin as a strategy for treating muscle wasting , 2018, Scientific Reports.
[10] P. Hoodless,et al. Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. , 1998, Molecular cell.
[11] J. Massagué,et al. Structural determinants of Smad function in TGF-β signaling. , 2015, Trends in biochemical sciences.
[12] J. Massagué. TGFβ signalling in context , 2012, Nature Reviews Molecular Cell Biology.
[13] X. Qi,et al. Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[14] Scott E. Kern,et al. DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1 , 1996, Science.
[15] G. Sapkota,et al. Phosphatases in SMAD regulation , 2012, FEBS letters.
[16] C. Glass,et al. Towards an understanding of cell-specific functions of signal-dependent transcription factors. , 2013, Journal of molecular endocrinology.
[17] Ming O. Li,et al. Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development. , 2010, Immunity.
[18] J. Massagué,et al. Metastatic colonization by circulating tumour cells , 2016, Nature.
[19] J. Picard,et al. AMH and AMH receptor defects in persistent Müllerian duct syndrome. , 2005, Human reproduction update.
[20] M. Quintanilla,et al. Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. , 2003, The Journal of biological chemistry.
[21] K. Luo. Ski and SnoN: negative regulators of TGF-beta signaling. , 2004, Current opinion in genetics & development.
[22] E. Fuchs,et al. Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. , 2007, Cancer cell.
[23] C. Hill,et al. TGF-β signaling to chromatin: how Smads regulate transcription during self-renewal and differentiation. , 2014, Seminars in cell & developmental biology.
[24] T. Ichisaka,et al. Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast. , 2014, Developmental biology.
[25] Xiao-Fan Wang,et al. Signaling cross-talk between TGF-β/BMP and other pathways , 2009, Cell Research.
[26] J. Massagué,et al. The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells. , 2017, Cell stem cell.
[27] Tessa G. Montague,et al. Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm , 2017, eLife.
[28] C. Iacobuzio-Donahue,et al. TGF-β Tumor Suppression through a Lethal EMT , 2016, Cell.
[29] J. Massagué,et al. TGFβ in Cancer , 2008, Cell.
[30] J. Wallingford,et al. P53 activity is essential for normal development in Xenopus , 1997, Current Biology.
[31] Maria I Morasso,et al. Dlx3 is a crucial regulator of hair follicle differentiation and cycling , 2008, Development.
[32] M. Trotter,et al. Pluripotency factors regulate definitive endoderm specification through eomesodermin. , 2011, Genes & development.
[33] Jeffrey L. Wrana,et al. TGFβ signals through a heteromeric protein kinase receptor complex , 1992, Cell.
[34] J. Massagué,et al. Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus , 2003, Cell.
[35] R. Fleming,et al. Bone morphogenetic proteins as regulators of iron metabolism. , 2014, Annual review of nutrition.
[36] T. B. Thompson,et al. The DAN family: Modulators of TGF‐β signaling and beyond , 2014, Protein science : a publication of the Protein Society.
[37] M. Ascano,et al. Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome , 2016, Science Signaling.
[38] Camille Stephan-Otto Attolini,et al. TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis , 2018, Nature.
[39] J. Stavnezer,et al. Analysis of transforming growth factor‐β1‐induced Ig germ‐line γ2b transcription and its implication for IgA isotype switching , 2005, European journal of immunology.
[40] H. Moses,et al. Growth inhibitor from BSC-1 cells closely related to platelet type beta transforming growth factor. , 1984, Science.
[41] D. Kessler,et al. Transcriptional integration of Wnt and Nodal pathways in establishment of the Spemann organizer. , 2012, Developmental biology.
[42] R. Burdine,et al. Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning , 2017, eLife.
[43] K. Burns,et al. Genetics of mammalian reproduction: modeling the end of the germline. , 2012, Annual review of physiology.
[44] M. Sporn,et al. Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo. , 1983, Science.
[45] J. Wrana,et al. Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells. , 2013, Cell reports.
[46] H. Friess,et al. Enhanced expression of transforming growth factor β isoforms in pancreatic cancer correlates with decreased survival , 1993 .
[47] J. Massagué,et al. Transforming growth factor (cid:1) -induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation , 2022 .
[48] Shawn C. Little,et al. BMP heterodimers assemble hetero-type I receptor complexes that pattern the DV axis , 2009, Nature Cell Biology.
[49] Shinichiro,et al. Carcinoma , 1906, The Hospital.
[50] J. Massagué,et al. Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors , 2017, Nature Communications.
[51] H. Yost,et al. Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish , 2017, eLife.
[52] H. Othmer,et al. Facilitated Transport of a Dpp/Scw Heterodimer by Sog/Tsg Leads to Robust Patterning of the Drosophila Blastoderm Embryo , 2005, Cell.
[53] J. Massagué,et al. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. , 2003, Cell.
[54] A. Madi,et al. The transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program , 2017, Nature Immunology.
[55] K. Luo. Ski and SnoN: negative regulators of TGF-β signaling , 2004 .
[56] Yue Zhang,et al. Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity , 2005, Science.
[57] H. Friess,et al. Enhanced expression of the type II transforming growth factor-beta receptor is associated with decreased survival in human pancreatic cancer. , 1999, Pancreas.
[58] S. Anderson,et al. Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation , 2004, Cell.
[59] S. Newfeld,et al. Regulation of TGF‐β signal transduction by mono‐ and deubiquitylation of Smads , 2012, FEBS letters.
[60] R. Derynck,et al. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. , 1998, Genes & development.
[61] E. Fuchs,et al. The harmonies played by TGF-β in stem cell biology. , 2012, Cell stem cell.
[62] James M. Roberts,et al. Cloning of p27 Kip1 , a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals , 1994, Cell.
[63] Ken W. Y. Cho,et al. Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program. , 2017, Developmental cell.
[64] W. Vale,et al. Roles of activin family in pancreatic development and homeostasis , 2012, Molecular and Cellular Endocrinology.
[65] Roger A. Pedersen,et al. Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells , 2015, Development.
[66] Gerald C. Chu,et al. SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression , 2011, Nature.
[67] Aaron M Zorn,et al. Vertebrate endoderm development and organ formation. , 2009, Annual review of cell and developmental biology.
[68] Gerhard Christofori,et al. Epithelial-mesenchymal transition (EMT) and metastasis: yes, no, maybe? , 2016, Current opinion in cell biology.
[69] D. de Sanctis,et al. Supplemental Information Structural Basis of the Human Endoglin-BMP 9 Interaction : Insights into BMP Signaling and HHT 1 , 2017 .
[70] Yibin Kang,et al. Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. , 2011, Cancer cell.
[71] J. Massagué,et al. Physical and Functional Interaction of SMADs and p300/CBP* , 1998, The Journal of Biological Chemistry.
[72] Y. Kalaidzidis,et al. Kinetics of Morphogen Gradient Formation , 2007, Science.
[73] Minoru Watanabe,et al. Smad4 and FAST-1 in the assembly of activin-responsive factor , 1997, Nature.
[74] C. Heldin. TGF-beta signaling from receptors to Smads , 2008 .
[75] T. Hunter,et al. TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. , 1998, Genes & development.
[76] A. Brivanlou,et al. Dephosphorylation of the Linker Regions of Smad1 and Smad2/3 by Small C-terminal Domain Phosphatases Has Distinct Outcomes for Bone Morphogenetic Protein and Transforming Growth Factor-β Pathways* , 2006, Journal of Biological Chemistry.
[77] E. Robertis,et al. Integrating Patterning Signals: Wnt/GSK3 Regulates the Duration of the BMP/Smad1 Signal , 2007, Cell.
[78] Shyam Prabhakar,et al. Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-β effectors , 2010, Nucleic acids research.
[79] Xin-Hua Feng,et al. Smad2 Positively Regulates the Generation of Th17 Cells* , 2010, The Journal of Biological Chemistry.
[80] A. Rudensky,et al. Regulatory T cells: mechanisms of differentiation and function. , 2012, Annual review of immunology.
[81] T. Springer,et al. Force interacts with macromolecular structure in activation of TGF-β , 2017, Nature.
[82] Richard A. Flavell,et al. Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation , 2002, The Journal of experimental medicine.
[83] C. Hill,et al. Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity. , 2002, Molecular cell.
[84] J. Chirgwin,et al. Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways. , 2002, The Journal of biological chemistry.
[85] Michael B. Elowitz,et al. Combinatorial Signal Perception in the BMP Pathway , 2017, Cell.
[86] C. Heldin,et al. Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition , 2016, Journal of clinical medicine.
[87] Elaine Fuchs,et al. TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma , 2015, Cell.
[88] Raymond B. Runyan,et al. Slug is an essential target of TGFbeta2 signaling in the developing chicken heart. , 2000, Developmental biology.
[89] David M Reynolds,et al. Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation. , 2012, Cell stem cell.
[90] Takeshi Imamura,et al. Role of Ras Signaling in the Induction of Snail by Transforming Growth Factor-β* , 2009, Journal of Biological Chemistry.
[91] A. Brivanlou,et al. Balancing BMP signaling through integrated inputs into the Smad1 linker. , 2007, Molecular cell.
[92] Yigong Shi,et al. Crystal Structure of a Smad MH1 Domain Bound to DNA Insights on DNA Binding in TGF-β Signaling , 1998, Cell.
[93] Bond-Smith Giles,et al. Only women with symptoms need to have their breast implants removed, says government , 2012 .
[94] T. Kornberg,et al. Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic , 2005, Nature.
[95] B. Song,et al. Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate , 2016, PLoS genetics.
[96] Shuichi Tsutsumi,et al. ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif , 2011, Nucleic acids research.
[97] George Q. Daley,et al. Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs during Differentiation and Regeneration , 2011, Cell.
[98] Florence March,et al. 2016 , 2016, Affair of the Heart.
[99] J. Wrana,et al. TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation. , 2017, Cold Spring Harbor perspectives in biology.
[100] Fang Liu,et al. Cyclin-dependent kinases regulate the antiproliferative function of Smads , 2004, Nature.
[101] H. Moses,et al. The roles of TGFβ in the tumour microenvironment , 2013, Nature Reviews Cancer.
[102] Janet Rossant,et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. , 2010, Developmental cell.
[103] R. Derynck,et al. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors , 1994, The Journal of cell biology.
[104] J. Wrana,et al. Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP‐dependent dendritogenesis , 2004, The EMBO journal.
[105] S. Dupont,et al. Links between Tumor Suppressors p53 Is Required for TGF-β Gene Responses by Cooperating with Smads , 2003, Cell.
[106] T. Nomura,et al. Control of Regulatory T Cell Development by the Transcription Factor Foxp3 , 2002 .
[107] G. Hannon,et al. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. , 1994, Nature.
[108] T. Tan,et al. Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients , 2014, EMBO molecular medicine.
[109] H. Dietz,et al. The genetic basis of aortic aneurysm. , 2014, Cold Spring Harbor perspectives in medicine.
[110] R. Young,et al. Super-Enhancers in the Control of Cell Identity and Disease , 2013, Cell.
[111] Yuelei Shen,et al. TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function , 2008, Nature.
[112] B. Ozdamar. Receptors Controls Epithelial Cell Plasticity Regulation of the Polarity Protein Par6 by TGFß , 2007 .
[113] J. Berzofsky,et al. Blockade of only TGF-β 1 and 2 is sufficient to enhance the efficacy of vaccine and PD-1 checkpoint blockade immunotherapy , 2017, Oncoimmunology.
[114] Charles Y. Lin,et al. Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers. , 2015, Molecular cell.
[115] J. Wrana,et al. Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development , 2007, The EMBO journal.
[116] Andrew C. Nelson,et al. In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors , 2017, Cell reports.
[117] David A. Orlando,et al. Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes , 2013, Cell.
[118] R. Sandberg,et al. BMP signaling and its pSMAD1/5 target genes differentially regulate hair follicle stem cell lineages. , 2014, Cell stem cell.
[119] K. Furuuchi,et al. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer , 2008, Nature Immunology.
[120] T. Watabe,et al. Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse. , 1995, Genes & development.
[121] N. Ling,et al. Pituitary FSH Is Released by a Heterodimer of the β-Subunits from the Two Forms of Inhibin , 1987 .
[122] D. Patel,et al. A Poised Chromatin Platform for TGF-β Access to Master Regulators , 2011, Cell.
[123] Yigong Shi,et al. A structural basis for mutational inactivation of the tumour suppressor Smad4 , 1997, Nature.
[124] Gerald C. Chu,et al. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. , 2006, Genes & development.
[125] K. Kinzler,et al. Human Smad3 and Smad4 are sequence-specific transcription activators. , 1998, Molecular cell.
[126] P. Jung,et al. Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation. , 2012, Cancer cell.
[127] A. Hinck,et al. Structural Biology and Evolution of the TGF-β Family. , 2016, Cold Spring Harbor perspectives in biology.
[128] Samy Lamouille,et al. Emergence of the Phosphoinositide 3-Kinase-Akt- Mammalian Target of Rapamycin Axis in Transforming Growth Factor-β-Induced Epithelial-Mesenchymal Transition , 2010, Cells Tissues Organs.
[129] Benjamin E. Gross,et al. Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal , 2013, Science Signaling.
[130] R. Derynck,et al. Structural and Functional Characterization of the Transforming Growth Factor-β-induced Smad3/c-Jun Transcriptional Cooperativity* , 2000, The Journal of Biological Chemistry.
[131] P. ten Dijke,et al. BMP signaling in vascular diseases , 2012, FEBS letters.
[132] M. Sporn,et al. Type beta transforming growth factor: a bifunctional regulator of cellular growth. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[133] J. Massagué,et al. A Smad action turnover switch operated by WW domain readers of a phosphoserine code. , 2011, Genes & development.
[134] A. Hata,et al. TGF-β Signaling from Receptors to Smads. , 2016, Cold Spring Harbor perspectives in biology.
[135] Camille Stephan-Otto Attolini,et al. Stromal gene expression defines poor-prognosis subtypes in colorectal cancer , 2015, Nature Genetics.
[136] T. Yamashita,et al. RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling. , 2017, Trends in cell biology.
[137] E. Jimi,et al. Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling , 2014, Scientific Reports.
[138] Sha Tian,et al. KLF5 Activates MicroRNA 200 Transcription To Maintain Epithelial Characteristics and Prevent Induced Epithelial-Mesenchymal Transition in Epithelial Cells , 2013, Molecular and Cellular Biology.
[139] U. Hellman,et al. PARP-1 attenuates Smad-mediated transcription. , 2010, Molecular cell.
[140] E. D. De Robertis,et al. Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. , 2003, Genes & development.
[141] J. Massagué. How cells read TGF-beta signals. , 2000, Nature reviews. Molecular cell biology.
[142] J. Massagué,et al. A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. , 2003, Molecular cell.
[143] D. Littman,et al. The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells , 2006, Cell.
[144] George Q. Daley,et al. Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs During Differentiation and Regeneration, , 2011 .
[145] J. Massagué,et al. Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. , 2002, Molecular cell.
[146] S. Germain,et al. Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. , 2000, Genes & development.
[147] R. Schulte‐Hermann,et al. Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness. , 2002, Journal of cell science.
[148] Sho Fujisawa,et al. Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways , 2009, Cell.
[149] Hans Clevers,et al. Signaling pathways in intestinal development and cancer. , 2004, Annual review of cell and developmental biology.
[150] David A. Orlando,et al. Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling , 2011, Cell.
[151] Jeffrey L. Wrana,et al. Signal integration in TGF-β, WNT, and Hippo pathways , 2013, F1000prime reports.
[152] Elisa de Stanchina,et al. Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT , 2016, Cell.
[153] Xiao-ming Meng,et al. TGF-β: the master regulator of fibrosis , 2016, Nature Reviews Nephrology.
[154] V. Yang,et al. Krüppel-like factor 5 is essential for proliferation and survival of mouse intestinal epithelial stem cells. , 2015, Stem cell research.
[155] S. Jameson,et al. Selection of self-reactive T cells in the thymus. , 2012, Annual review of immunology.
[156] H. Ng,et al. Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development , 2014, Gut.
[157] C. Heldin,et al. Signaling Receptors for TGF-β Family Members. , 2016, Cold Spring Harbor perspectives in biology.
[158] G. Natoli,et al. Dissection of transcriptional and cis‐regulatory control of differentiation in human pancreatic cancer , 2016, The EMBO journal.
[159] J. Massagué,et al. A Smad Transcriptional Corepressor , 1999, Cell.
[160] Vicki Rosen,et al. BMP signalling in skeletal development, disease and repair , 2016, Nature Reviews Endocrinology.
[161] P. D. Kraan,et al. The changing role of TGFβ in healthy, ageing and osteoarthritic joints , 2017, Nature Reviews Rheumatology.
[162] Shawn M. Gillespie,et al. Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer , 2017, Cell.
[163] A. Iavarone,et al. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. , 1995, Genes & development.
[164] Gregory J. Hannon,et al. pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest , 1994, Nature.
[165] B. Keller,et al. Interaction of TGFβ and BMP Signaling Pathways during Chondrogenesis , 2011, PloS one.
[166] H. Frierson,et al. Activation of Akt Signaling in Prostate Induces a TGFβ Mediated Restraint on Cancer Progression and Metastasis , 2013, Oncogene.
[167] D. Littman,et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. , 2006, Cell.
[168] Edward Chuong,et al. Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. , 2011, Developmental biology.
[169] L. Wakefield,et al. Beyond TGFβ: roles of other TGFβ superfamily members in cancer , 2013, Nature Reviews Cancer.
[170] H. Niwa,et al. Maintenance of pluripotency in mouse ES cells without Trp53 , 2013, Scientific Reports.
[171] M. Rugge,et al. Germ-Layer Specification and Control of Cell Growth by Ectodermin, a Smad4 Ubiquitin Ligase , 2005, Cell.
[172] E. Batlle,et al. Targeting the Microenvironment in Advanced Colorectal Cancer. , 2016, Trends in cancer.
[173] A. Stewart,et al. Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling , 2017, eLife.
[174] V. Lefebvre,et al. The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation , 2012, Nature Immunology.
[175] R. Bourgon,et al. TGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells , 2018, Nature.
[176] Wei He,et al. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[177] A. Bassols,et al. Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells , 1987, Nature.
[178] A. Barski,et al. Genomic integration of Wnt/β-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs , 2017, Development.
[179] David García-Dorado,et al. TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma. , 2009, Cancer cell.
[180] J. Chirgwin,et al. Transforming Growth Factor-Stimulates Parathyroid Hormone-related Protein and Osteolytic Metastases via Smad and Mitogen-activated Protein Kinase Signaling Pathways * , 2002 .
[181] J. Massagué,et al. E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression , 2002, Cell.
[182] Ming O. Li,et al. Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection. , 2017, Cold Spring Harbor perspectives in biology.
[183] J. Massagué,et al. The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors , 1987, Cell.
[184] T. Sjöblom,et al. Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis. , 2008, Oncogene.
[185] H. Moses,et al. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. , 2006, Genes & development.
[186] N. Bardeesy,et al. Pancreatic adenocarcinoma. , 2014, The New England journal of medicine.
[187] Robert Walgate,et al. Proliferation , 1985, Nature.
[188] K. Kinzler,et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. , 1995, Science.
[189] Osamu Shimmi,et al. Facilitated Transport of a Dpp/Scw Heterodimer by Sog/Tsg Leads to Robust Patterning of the Drosophila Blastoderm Embryo , 2005, Cell.
[190] J. Baker,et al. HEB associates with PRC2 and SMAD2/3 to regulate developmental fates , 2015, Nature Communications.
[191] M. Kretzschmar,et al. Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1 , 1997, Nature.
[192] R. Haydon,et al. Bone Morphogenetic Protein (BMP) signaling in development and human diseases , 2014, Genes & diseases.
[193] J. Massagué,et al. TGF beta signals through a heteromeric protein kinase receptor complex. , 1992, Cell.
[194] R. Weinberg,et al. Epithelial-Mesenchymal Plasticity: A Central Regulator of Cancer Progression. , 2015, Trends in cell biology.
[195] R Wieser,et al. Mechanism of activation of the TGF-beta receptor. , 1994, Nature.
[196] G. Sapkota,et al. The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways , 2014, Cellular signalling.
[197] T. Wirth,et al. Transforming growth factor beta and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site , 1993, Molecular and cellular biology.
[198] D. Brazil,et al. BMP signalling: agony and antagony in the family. , 2015, Trends in cell biology.
[199] Matthew Loose,et al. A genetic regulatory network for Xenopus mesendoderm formation. , 2004, Developmental biology.
[200] Robert A. Weinberg,et al. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. , 2008, Developmental cell.
[201] R. Morita,et al. Smad2 and Smad3 Are Redundantly Essential for the TGF-β–Mediated Regulation of Regulatory T Plasticity and Th1 Development , 2010, The Journal of Immunology.
[202] Li Li,et al. Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 , 2003, The Journal of experimental medicine.
[203] K. Jones,et al. SMADs and YAP compete to control elongation of β-catenin:LEF-1-recruited RNAPII during hESC differentiation. , 2015, Molecular cell.
[204] P. Dijke,et al. Immunoregulation by members of the TGFβ superfamily , 2016, Nature Reviews Immunology.
[205] Piotr J. Balwierz,et al. Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming. , 2013, Cancer cell.
[206] D. L. Weeks,et al. TGFbeta2 and TGFbeta3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart. , 1999, Developmental biology.
[207] Roger R. Gomis,et al. TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4 , 2008, Cell.
[208] J. Wrana,et al. BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis. , 1997, The American journal of physiology.
[209] S. Pauklin,et al. Activin/Nodal signalling in stem cells , 2015, Development.
[210] H. Beug,et al. TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. , 1996, Genes & development.
[211] H. Aburatani,et al. Genomewide Comprehensive Analysis Reveals Critical Cooperation Between Smad and c‐Fos in RANKL‐Induced Osteoclastogenesis , 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[212] A. Kotzsch,et al. GDF-5 can act as a context-dependent BMP-2 antagonist , 2015, BMC Biology.
[213] J. Massagué,et al. OAZ Uses Distinct DNA- and Protein-Binding Zinc Fingers in Separate BMP-Smad and Olf Signaling Pathways , 2000, Cell.