The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.

[1]  G. Häcker,et al.  cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms , 2011, Molecular cell.

[2]  M. Hinds,et al.  CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration. , 2011, Molecular cell.

[3]  A. Ashkenazi,et al.  NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling , 2011, Cell.

[4]  R. Hakem,et al.  RIP3 mediates the embryonic lethality of caspase-8-deficient mice , 2011, Nature.

[5]  D. Vaux,et al.  In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8* , 2011, The Journal of Biological Chemistry.

[6]  T. Tenev,et al.  Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2 , 2011, Cell Death and Differentiation.

[7]  Guy S. Salvesen,et al.  Catalytic activity of the caspase-8-FLIPL complex inhibits RIPK3-dependent necrosis , 2011, Nature.

[8]  D. Green,et al.  FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity. , 2011, The Biochemical journal.

[9]  F. Chan,et al.  Functional complementation between FADD and RIP1 in embryos and lymphocytes , 2011, Nature.

[10]  Youtong Wu,et al.  zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC–MAPKs–AP-1 pathway , 2011, Cell Death and Differentiation.

[11]  V. Stagni,et al.  ATM kinase activity modulates cFLIP protein levels: potential interplay between DNA damage signalling and TRAIL-induced apoptosis. , 2010, Carcinogenesis.

[12]  G. Dittmar,et al.  A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. , 2010, Molecular cell.

[13]  Zhijian J. Chen,et al.  ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress. , 2010, Molecular cell.

[14]  P. Vandenabeele,et al.  Molecular mechanisms of necroptosis: an ordered cellular explosion , 2010, Nature Reviews Molecular Cell Biology.

[15]  Pascal Meier,et al.  IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer , 2010, Nature Reviews Cancer.

[16]  P. Vandenabeele,et al.  Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features , 2010, Cell Death and Differentiation.

[17]  D. Vaux,et al.  RIPK1 is not essential for TNFR1-induced activation of NF-κB , 2010, Cell Death and Differentiation.

[18]  M. Verheij,et al.  Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation , 2010, Cell Death and Differentiation.

[19]  Y. Wu,et al.  TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion , 2010, British Journal of Cancer.

[20]  H. Gollnick,et al.  Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment , 2009, The Journal of cell biology.

[21]  P. Meier,et al.  A tangled web of ubiquitin chains: breaking news in TNF-R1 signaling. , 2009, Molecular cell.

[22]  Christoph H Emmerich,et al.  Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. , 2009, Molecular cell.

[23]  Erinna F. Lee,et al.  TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis , 2009, The Journal of Biological Chemistry.

[24]  R. Korneluk,et al.  Down-regulation of c-FLIP Enhances death of cancer cells by smac mimetic compound. , 2009, Cancer research.

[25]  S. Huerta,et al.  Smac mimetics as new cancer therapeutics , 2009, Anti-cancer drugs.

[26]  Christoph Borner,et al.  XIAP discriminates between type I and type II FAS-induced apoptosis , 2009, Nature.

[27]  Na Zhang,et al.  RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis , 2009, Science.

[28]  F. Chan,et al.  Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation , 2009, Cell.

[29]  Tao Wang,et al.  Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α , 2009, Cell.

[30]  Vishva Dixit,et al.  Death receptor signal transducers: nodes of coordination in immune signaling networks , 2009, Nature Immunology.

[31]  Wan-Wan Lin,et al.  Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis , 2009, Nature.

[32]  Mu-xiang Zhou,et al.  Expression of TNF-α leader sequence renders MCF-7 tumor cells resistant to the cytotoxicity of soluble TNF-α , 2009, Breast Cancer Research and Treatment.

[33]  Kristoffer T G Rigbolt,et al.  Inactivation of effector caspases through nondegradative polyubiquitylation. , 2008, Molecular cell.

[34]  M. Zvelebil,et al.  IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis , 2008, Nature Cell Biology.

[35]  S. Shankar,et al.  Smac/DIABLO enhances the therapeutic potential of chemotherapeutic drugs and irradiation, and sensitizes TRAIL-resistant breast cancer cells , 2008, Molecular Cancer.

[36]  M. Bertrand,et al.  cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. , 2008, Molecular cell.

[37]  Xiaodong Wang,et al.  TNF-α Induces Two Distinct Caspase-8 Activation Pathways , 2008, Cell.

[38]  Alexei Degterev,et al.  Identification of RIP1 kinase as a specific cellular target of necrostatins. , 2008, Nature chemical biology.

[39]  W. Sellers,et al.  A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling. , 2007, Cancer research.

[40]  K. Vousden,et al.  Lucifer's labyrinth--ten years of path finding in cell death. , 2007, Molecular cell.

[41]  David L. Vaux,et al.  IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis , 2007, Cell.

[42]  J. Minna,et al.  Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. , 2007, Cancer cell.

[43]  R. Korneluk,et al.  The inhibitors of apoptosis (IAPs) as cancer targets , 2007, Apoptosis.

[44]  T. Tenev,et al.  The antiapoptotic activity of insect IAPs requires activation by an evolutionarily conserved mechanism , 2007, Cell Death and Differentiation.

[45]  Wan-Wan Lin,et al.  A cytokine-mediated link between innate immunity, inflammation, and cancer. , 2007, The Journal of clinical investigation.

[46]  Vinay Tergaonkar,et al.  IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. , 2007, Cell.

[47]  Vishva M Dixit,et al.  IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. , 2007, Cell.

[48]  G. Salvesen,et al.  Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family , 2006, EMBO reports.

[49]  D. Vaux,et al.  Apoptosis in the development and treatment of cancer. , 2004, Carcinogenesis.

[50]  G. Salvesen,et al.  Activation of caspases-8 and -10 by FLIP(L). , 2004, The Biochemical journal.

[51]  W. Stremmel,et al.  Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs , 2004, Cell Death and Differentiation.

[52]  J. Tschopp,et al.  N-Terminal Fragment of c-FLIP(L) Processed by Caspase 8 Specifically Interacts with TRAF2 and Induces Activation of the NF-κB Signaling Pathway , 2004, Molecular and Cellular Biology.

[53]  M. Herlyn,et al.  Cisplatin down-regulation of cellular Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory proteins to restore tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human melanoma cells. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[54]  J. Tschopp,et al.  Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes , 2003, Cell.

[55]  J. Tschopp,et al.  Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNFα-Mediated NF-κB Activation , 2003 .

[56]  J. Tschopp,et al.  Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. , 2003, Immunity.

[57]  J. Tschopp,et al.  The Long Form of FLIP Is an Activator of Caspase-8 at the Fas Death-inducing Signaling Complex* , 2002, The Journal of Biological Chemistry.

[58]  G. Salvesen,et al.  Inhibitor specificity of recombinant and endogenous caspase-9. , 2002, The Biochemical journal.

[59]  G. Cohen,et al.  Physiological Concentrations of K+ Inhibit Cytochrome c-dependent Formation of the Apoptosome* , 2001, The Journal of Biological Chemistry.

[60]  G. Peters,et al.  Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460. , 2000, Cancer research.

[61]  Yili Yang,et al.  Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. , 2000, Science.

[62]  Gail Walker,et al.  Apaf-1 Oligomerizes into Biologically Active ∼700-kDa and Inactive ∼1.4-MDa Apoptosome Complexes* , 2000, The Journal of Biological Chemistry.

[63]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[64]  G. Salvesen,et al.  Viral caspase inhibitors CrmA and p35. , 2000, Methods in enzymology.

[65]  G M Cohen,et al.  Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes. , 2000, The Journal of biological chemistry.

[66]  R. Hay,et al.  SUMO‐1 modification activates the transcriptional response of p53 , 1999, The EMBO journal.

[67]  A. MacKenzie,et al.  The inhibitors of apoptosis (IAPs) and their emerging role in cancer , 1998, Oncogene.

[68]  W. Fiers,et al.  Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor , 1998, The Journal of experimental medicine.

[69]  G. Salvesen,et al.  FLICE Induced Apoptosis in a Cell-free System , 1997, The Journal of Biological Chemistry.

[70]  E. Russell,et al.  Fas expression and function in normal and malignant breast cell lines. , 1996, Cancer research.