Intracellular mechanism of penile erection in monkeys

To elucidate the sequence of events between the release of neurotransmitters and cavernous smooth muscle relaxation in erection, we studied the role of the cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) systems. In a well‐established simian model, the effects of specific agonists and antagonists of the intracellular sequence for smooth muscle relaxation and potassium channel openers on the intracavernous pressure were examined.

[1]  S. L. Andersen,et al.  Calcitonin gene-related peptide stimulates active Na(+)-K+ transport in rat soleus muscle. , 1993, American Journal of Physiology.

[2]  I. Goldstein,et al.  A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. , 1991, The Journal of clinical investigation.

[3]  E. H. Blaine,et al.  Hemodynamic basis for the depressor activity of zaprinast, a selective cyclic GMP phosphodiesterase inhibitor. , 1991, The Journal of pharmacology and experimental therapeutics.

[4]  P. Vanhoutte,et al.  Endothelium‐derived relaxing and contracting factors , 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  L. Ignarro,et al.  Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. , 1990, Biochemical and biophysical research communications.

[6]  A. Sinha,et al.  Stimulation of prostaglandin E1 binding to human blood platelet membrane by insulin and the activation of adenylate cyclase. , 1990, The Journal of biological chemistry.

[7]  Y. Matsumura,et al.  Effects of BRL 34915 (cromakalim) on renal hemodynamics and function in anesthetized dogs. , 1990, The Journal of pharmacology and experimental therapeutics.

[8]  F. Bénard,et al.  A possible role for calcitonin-gene-related peptide in the regulation of the smooth muscle tone of the bladder and penis. , 1990, The Journal of urology.

[9]  F. Freiha,et al.  Orchiectomy only for clinical stage I nonseminomatous germ cell testis tumors: comparison with pathologic stage I disease. , 1989, Urology.

[10]  F. Bénard,et al.  Acetylcholine as a possible neurotransmitter in penile erection. , 1989, The Journal of urology.

[11]  S. Rattan,et al.  Influence of stimulators and inhibitors of cyclic nucleotides on lower esophageal sphincter. , 1989, The Journal of pharmacology and experimental therapeutics.

[12]  T. Lincoln,et al.  Cyclic GMP and mechanisms of vasodilation. , 1989, Pharmacology & therapeutics.

[13]  F. Hofmann,et al.  Cyclic GMP-dependent protein kinase stimulates the plasmalemmal Ca2+ pump of smooth muscle via phosphorylation of phosphatidylinositol. , 1988, The Biochemical journal.

[14]  A. Levitzki.  From epinephrine to cyclic AMP. , 1988, Science.

[15]  U. Walter,et al.  Intracellular mechanism of action of vasodilators. , 1988, European heart journal.

[16]  F. Murad,et al.  Biochemical Mechanisms Underlying Vascular Smooth Muscle Relaxation: The Guanylate Cyclase‐Cyclic GMP System , 1988, Journal of cardiovascular pharmacology.

[17]  T. Lue,et al.  The role of vasoactive intestinal polypeptide as a neurotransmitter in canine penile erection: a combined in vivo and immunohistochemical study. , 1987, The Journal of urology.

[18]  L. Ignarro,et al.  The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation. , 1985, Annual review of pharmacology and toxicology.

[19]  T. Lue,et al.  Hemodynamics of canine corpora cavernosa during erection. , 1984, Urology.

[20]  T F Lue,et al.  Hemodynamics of erection in the monkey. , 1983, The Journal of urology.

[21]  L. Ignarro,et al.  Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. , 1981, The Journal of pharmacology and experimental therapeutics.

[22]  R. Furchgott,et al.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine , 1980, Nature.

[23]  L. Ignarro,et al.  Possible involvement of S‐nitrosothiols in the activation of guanylate cyclase by nitroso compounds , 1980, FEBS letters.

[24]  L. Birnbaumer,et al.  The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. IV. Effects of guanylnucleotides on binding of 125I-glucagon. , 1971, The Journal of biological chemistry.

[25]  E. Sutherland,et al.  Adenyl Cyclase I. DISTRIBUTION, PREPARATION, AND PROPERTIES , 1962 .