NFBD1/MDC1 stabilizes oncogenic MDM2 to contribute to cell fate determination in response to DNA damage.

[1]  Hong Wang,et al.  A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53. , 2008, Biochemical and biophysical research communications.

[2]  A. Nakagawara,et al.  Sp1‐mediated transcriptional regulation of NFBD1/MDC1 plays a critical role in DNA damage response pathway , 2007, Genes to cells : devoted to molecular & cellular mechanisms.

[3]  A. Nakagawara,et al.  NFBD1/MDC1 Associates with p53 and Regulates Its Function at the Crossroad between Cell Survival and Death in Response to DNA Damage* , 2007, Journal of Biological Chemistry.

[4]  K. Kohn,et al.  Dose–response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686288) , 2007, Oncogene.

[5]  Jian Jian Li,et al.  siRNA-mediated MDM2 inhibition sensitizes human lung cancer A549 cells to radiation. , 2007, International journal of oncology.

[6]  F. Alt,et al.  MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. , 2006, Molecular cell.

[7]  J. Kobayashi,et al.  Molecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to gamma-H2AX through FHA/BRCT domain. , 2004, Journal of radiation research.

[8]  D. Stern,et al.  NFBD1/MDC1 regulates ionizing radiation‐induced focus formation by DNA checkpoint signaling and repair factors , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[9]  Phang-lang Chen,et al.  NFBD1, Like 53BP1, Is an Early and Redundant Transducer Mediating Chk2 Phosphorylation in Response to DNA Damage* , 2003, The Journal of Biological Chemistry.

[10]  J. Bartek,et al.  MDC1 is required for the intra-S-phase DNA damage checkpoint , 2003, Nature.

[11]  Junjie Chen,et al.  MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways , 2003, Nature.

[12]  Stephen J. Elledge,et al.  MDC1 is a mediator of the mammalian DNA damage checkpoint , 2003, Nature.

[13]  A. Nussenzweig,et al.  DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1 , 2002, Nature Cell Biology.

[14]  Xin Lu,et al.  Live or let die: the cell's response to p53 , 2002, Nature Reviews Cancer.

[15]  F. Alt,et al.  Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Michel C. Nussenzweig,et al.  Genomic Instability in Mice Lacking Histone H2AX , 2002, Science.

[17]  N. Nomura,et al.  NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain. , 2000, DNA and cell biology.

[18]  N. Shao,et al.  The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter , 1999, Oncogene.

[19]  P. Bork,et al.  Protein sequence motifs. , 1996, Current opinion in structural biology.

[20]  N. Nomura,et al.  Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. , 1996, DNA research : an international journal for rapid publication of reports on genes and genomes.

[21]  N. Nomura,et al.  Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. , 1996, DNA research : an international journal for rapid publication of reports on genes and genomes.

[22]  N. Nomura,et al.  Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. , 1995, DNA research : an international journal for rapid publication of reports on genes and genomes.

[23]  S. Fields,et al.  Two cellular proteins that bind to wild-type but not mutant p53. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[24]  P. Meltzer,et al.  p53 Mutation and MDM2 amplification in human soft tissue sarcomas. , 1993, Cancer research.