Structural Basis for the Inhibition of Caspase-3 by XIAP

[1]  G M Kasof,et al.  Livin, a Novel Inhibitor of Apoptosis Protein Family Member* , 2001, The Journal of Biological Chemistry.

[2]  Geng Wu,et al.  Structural basis of IAP recognition by Smac/DIABLO , 2000, Nature.

[3]  Stephen F. Betz,et al.  Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain , 2000, Nature.

[4]  S. Srinivasula,et al.  Molecular Determinants of the Caspase-promoting Activity of Smac/DIABLO and Its Role in the Death Receptor Pathway* , 2000, The Journal of Biological Chemistry.

[5]  G. Salvesen,et al.  ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas , 2000, Current Biology.

[6]  Stephen W. Fesik,et al.  NMR Structure and Mutagenesis of the Third Bir Domain of the Inhibitor of Apoptosis Protein XIAP* , 2000, The Journal of Biological Chemistry.

[7]  R. Read,et al.  Structure of a serpin–protease complex shows inhibition by deformation , 2000, Nature.

[8]  P. Krammer,et al.  CD95's deadly mission in the immune system , 2000, Nature.

[9]  G. Salvesen,et al.  Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8. , 2000, The Biochemical journal.

[10]  Tony Hunter,et al.  Structural basis for phosphoserine-proline recognition by group IV WW domains , 2000, Nature Structural Biology.

[11]  Xiaodong Wang,et al.  Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition , 2000, Cell.

[12]  Robert L Moritz,et al.  Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins , 2000, Cell.

[13]  Robert L. Margolis,et al.  Crystal Structure of Human Survivin Reveals a Bow Tie?Shaped Dimer with Two Unusual ?-Helical Extensions , 2000 .

[14]  S. Muchmore,et al.  Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin. , 2000, Molecular cell.

[15]  J. Noel,et al.  Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement , 2000, Nature Structural Biology.

[16]  K. Wilson,et al.  The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity. , 2000, Chemistry & biology.

[17]  D. Turk,et al.  Lysosomal cysteine proteases: more than scavengers. , 2000, Biochimica et biophysica acta.

[18]  R. Huber,et al.  Structural basis of the endoproteinase-protein inhibitor interaction. , 2000, Biochimica et biophysica acta.

[19]  G. Salvesen,et al.  Viral caspase inhibitors CrmA and p35. , 2000, Methods in enzymology.

[20]  R. Flavell,et al.  Caspase knockouts: matters of life and death , 1999, Cell Death and Differentiation.

[21]  D. Nicholson,et al.  Caspase structure, proteolytic substrates, and function during apoptotic cell death , 1999, Cell Death and Differentiation.

[22]  Stephen W. Fesik,et al.  NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP , 1999, Nature.

[23]  J C Reed,et al.  Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases , 1999, The EMBO journal.

[24]  M. Grütter,et al.  The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis. , 1999, Structure.

[25]  A. Tomasselli,et al.  The atomic-resolution structure of human caspase-8, a key activator of apoptosis. , 1999, Structure.

[26]  D. Vaux,et al.  Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat , 1999, Nature Structural Biology.

[27]  G. Salvesen,et al.  Caspases: preparation and characterization. , 1999, Methods.

[28]  Thomas C. Terwilliger,et al.  Automated MAD and MIR structure solution , 1999, Acta crystallographica. Section D, Biological crystallography.

[29]  J. Silke,et al.  Caspase inhibitors , 1999, Cell Death and Differentiation.

[30]  N. Thornberry,et al.  Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors* , 1998, The Journal of Biological Chemistry.

[31]  J C Reed,et al.  Pro-caspase-3 Is a Major Physiologic Target of Caspase-8* , 1998, The Journal of Biological Chemistry.

[32]  R J Read,et al.  Crystallography & NMR system: A new software suite for macromolecular structure determination. , 1998, Acta crystallographica. Section D, Biological crystallography.

[33]  Y. Lazebnik,et al.  Caspases: enemies within. , 1998, Science.

[34]  Keisuke Kuida,et al.  Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9 , 1998, Cell.

[35]  José Luis de la Pompa,et al.  Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo , 1998, Cell.

[36]  J. Beckmann,et al.  Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. , 1998, Immunity.

[37]  E. Alnemri,et al.  Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex. , 1998, Biochemistry.

[38]  D. Vaux,et al.  Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts. , 1998, Trends in biochemical sciences.

[39]  J C Reed,et al.  IAPs block apoptotic events induced by caspase‐8 and cytochrome c by direct inhibition of distinct caspases , 1998, The EMBO journal.

[40]  J C Reed,et al.  A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases* , 1998, The Journal of Biological Chemistry.

[41]  John Calvin Reed,et al.  The c‐IAP‐1 and c‐IAP‐2 proteins are direct inhibitors of specific caspases , 1997, The EMBO journal.

[42]  N. Thornberry,et al.  A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B , 1997, The Journal of Biological Chemistry.

[43]  Guy S. Salvesen,et al.  X-linked IAP is a direct inhibitor of cell-death proteases , 1997, Nature.

[44]  G. Salvesen,et al.  Target Protease Specificity of the Viral Serpin CrmA , 1997, The Journal of Biological Chemistry.

[45]  M. Grütter,et al.  Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone* , 1997, The Journal of Biological Chemistry.

[46]  Z. Otwinowski,et al.  [20] Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.

[47]  Keisuke Kuida,et al.  Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice , 1996, Nature.

[48]  N. Thornberry,et al.  The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis , 1996, Nature Structural Biology.

[49]  E A Merritt,et al.  Raster3D Version 2.0. A program for photorealistic molecular graphics. , 1994, Acta crystallographica. Section D, Biological crystallography.

[50]  Collaborative Computational,et al.  The CCP4 suite: programs for protein crystallography. , 1994, Acta crystallographica. Section D, Biological crystallography.

[51]  J. Mankovich,et al.  Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer , 1994, Cell.

[52]  J. Navaza,et al.  AMoRe: an automated package for molecular replacement , 1994 .

[53]  M. Murcko,et al.  Structure and mechanism of interleukin-1 beta converting enzyme. , 1994, Nature.

[54]  J. Beechem,et al.  Mechanism of serpin action: evidence that C1 inhibitor functions as a suicide substrate. , 1991, Biochemistry.

[55]  R. Huber,et al.  Accurate Bond and Angle Parameters for X-ray Protein Structure Refinement , 1991 .

[56]  Robert Huber,et al.  Ligand binding: proteinase-protein inhibitor interactions , 1991 .

[57]  R. Huber,et al.  The structure of a complex of recombinant hirudin and human alpha-thrombin. , 1990, Science.

[58]  R. Huber,et al.  The refined 2.4 A X‐ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction. , 1990, The EMBO journal.

[59]  C. Walsh,et al.  The behavior and significance of slow-binding enzyme inhibitors. , 2006, Advances in enzymology and related areas of molecular biology.

[60]  A. F. Bury.  Analysis of protein and peptide mixtures , 1981 .

[61]  H. Kirschke,et al.  Lysosomal cysteine proteinases. , 1998, Ciba Foundation symposium.

[62]  O. Schreiner,et al.  CHOLESTEROL BODIES IN SOILS: PHYTOSTEROL , 1911 .