Nitric Oxide Decreases the Enzymatic Activity of Insulin Degrading Enzyme in APP/PS1 Mice

[1]  F. Jessen,et al.  Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation , 2011, Neuron.

[2]  D. Selkoe.  Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.

[3]  M. Siepmann,et al.  Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion* , 2010, The Journal of Biological Chemistry.

[4]  M. O’Banion,et al.  Neuroinflammatory processes in Alzheimer’s disease , 2010, Journal of Neural Transmission.

[5]  Fred H. Gage,et al.  Mechanisms Underlying Inflammation in Neurodegeneration , 2010, Cell.

[6]  Huaxi Xu,et al.  Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain amyloid-beta degrading protease. , 2010, Journal of Alzheimer's disease : JAD.

[7]  Wei-Jen Tang,et al.  Protective Role of Cys-178 against the Inactivation and Oligomerization of Human Insulin-degrading Enzyme by Oxidation and Nitrosylation* , 2009, The Journal of Biological Chemistry.

[8]  F. Hamel,et al.  Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation. , 2009, Biochemical pharmacology.

[9]  Stuart A. Lipton,et al.  Cell death: protein misfolding and neurodegenerative diseases , 2009, Apoptosis.

[10]  Rafael Radi,et al.  Protein tyrosine nitration--functional alteration or just a biomarker? , 2008, Free radical biology & medicine.

[11]  E. Malito,et al.  Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin , 2008, Cellular and Molecular Life Sciences.

[12]  Nastaran Gharkholonarehe,et al.  Progression of Amyloid Pathology to Alzheimer's Disease Pathology in an Amyloid Precursor Protein Transgenic Mouse Model by Removal of Nitric Oxide Synthase 2 , 2008, The Journal of Neuroscience.

[13]  D. Butterfield,et al.  Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: Implications for the role of nitration in the progression of Alzheimer's disease , 2007, Brain Research.

[14]  M. Nieto,et al.  Nitric oxide in the cerebral cortex of amyloid-precursor protein (SW) Tg2576 transgenic mice , 2004, Neuroscience.

[15]  A. Gow,et al.  Biological significance of nitric oxide-mediated protein modifications. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[16]  Rafael Radi,et al.  Nitric oxide, oxidants, and protein tyrosine nitration , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[17]  J. Rodrigo,et al.  Expression of nitric oxide system in clinically evaluated cases of Alzheimer's disease , 2004, Neurobiology of Disease.

[18]  C. Gutiérrez-Merino,et al.  Fluorescence Measurements of Steady State Peroxynitrite Production Upon SIN-1 Decomposition: NADH Versus Dihydrodichlorofluorescein and Dihydrorhodamine 123 , 2004, Journal of Fluorescence.

[19]  L. Hersh,et al.  Substrate Activation of Insulin-degrading Enzyme (Insulysin) , 2003, Journal of Biological Chemistry.

[20]  Visith Thongboonkerd,et al.  Proteomic identification of nitrated proteins in Alzheimer's disease brain , 2003, Journal of neurochemistry.

[21]  Matthew P. Frosch,et al.  Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[22]  D. Selkoe,et al.  Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[23]  T. Arendt,et al.  Aberrant expression of NOS isoforms in Alzheimer’s disease is structurally related to nitrotyrosine formation , 2002, Brain Research.

[24]  M. Staufenbiel,et al.  Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer’s disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology , 2001, Brain Research.

[25]  T. Klockgether,et al.  Neuronal and Glial Coexpression of Argininosuccinate Synthetase and Inducible Nitric Oxide Synthase in Alzheimer Disease , 2001, Journal of neuropathology and experimental neurology.

[26]  D. Borchelt,et al.  Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. , 2001, Biomolecular engineering.

[27]  G. Chaudhuri,et al.  Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): Potential role of cyclin D1 , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[28]  T. Saido,et al.  Reply to: 'Clearance of amyloid β-peptide from brain: transport or metabolism?' , 2000, Nature Medicine.

[29]  T. Saido,et al.  Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition , 2000, Nature Medicine.

[30]  D. Dickson,et al.  Inducible nitric oxide synthase immunoreactivity in the Alzheimer disease hippocampus: association with Hirano bodies, neurofibrillary tangles, and senile plaques. , 1999, Journal of neuropathology and experimental neurology.

[31]  H. Tohgi,et al.  Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease , 1999, Neuroscience Letters.

[32]  W. Markesbery,et al.  Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation , 1998, The Journal of Neuroscience.

[33]  Eric J. Toone,et al.  (S)NO Signals: Translocation, Regulation, and a Consensus Motif , 1997, Neuron.

[34]  Joseph S. Beckman,et al.  Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease , 1997, The Journal of Neuroscience.

[35]  M. Sporn,et al.  Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease , 1996, The Journal of experimental medicine.

[36]  A. Holmgren,et al.  S-Nitrosoglutathione Is Cleaved by the Thioredoxin System with Liberation of Glutathione and Redox Regulating Nitric Oxide* , 1996, The Journal of Biological Chemistry.

[37]  H. Ischiropoulos,et al.  Detection and quantitation of nitrotyrosine residues in proteins: in vivo marker of peroxynitrite. , 1996, Methods in enzymology.

[38]  O. Smithies,et al.  Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. , 1995, Proceedings of the National Academy of Sciences of the United States of America.