Large-scale activity in neural nets II: A model for the brainstem respiratory oscillator

The formalism developed in a previous paper (Feldman and Cowan, 1974) for the analysis of large scale activity in neural nets is applied to the problem of accounting for the generation and maintenance of respiratory related rhythms in the brain stem. It is shown that coupled nets of excitatory and inhibitory cells can generate slowly augmenting respiratory related activity, and that rapid switching from inspiratory related to expiratory related activity can take place. The effects of lung inflation, CO2 inhalation, and brain stem lesions are deduced from the model, and certain predictions are made concerning inhibition in the brain stem.

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