Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.

[1]  Jeffrey M Peters,et al.  Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.

[2]  S. Chakraborty,et al.  Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells , 2011, British Journal of Cancer.

[3]  A. H. Tolson,et al.  Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR. , 2010, Advanced drug delivery reviews.

[4]  D. Nie,et al.  Camptothecin Attenuates Cytochrome P450 3A4 Induction by Blocking the Activation of Human Pregnane X Receptor , 2010, Journal of Pharmacology and Experimental Therapeutics.

[5]  Jianming Xu,et al.  Coactivators in PPAR-Regulated Gene Expression , 2010, PPAR research.

[6]  S. Duensing,et al.  A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention , 2010, Molecular Cancer.

[7]  S. Surapureddi,et al.  Hepatocyte Nuclear Factor 4α Regulates Rifampicin-Mediated Induction of CYP2C Genes in Primary Cultures of Human Hepatocytes , 2010, Drug Metabolism and Disposition.

[8]  R. Gearry,et al.  Azathioprine and allopurinol: A two‐edged interaction , 2010, Journal of gastroenterology and hepatology.

[9]  Hongbing Wang,et al.  Activation of xenobiotic receptors: driving into the nucleus , 2010, Expert opinion on drug metabolism & toxicology.

[10]  K. Yoshinari,et al.  Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region. , 2010, Biochemical pharmacology.

[11]  B. Hagenbuch.  Drug Uptake Systems in Liver and Kidney: A Historic Perspective , 2010, Clinical pharmacology and therapeutics.

[12]  Sean Ekins,et al.  Challenges Predicting Ligand-Receptor Interactions of Promiscuous Proteins: The Nuclear Receptor PXR , 2009, PLoS Comput. Biol..

[13]  W. Xie,et al.  The Aldo-Keto Reductase Akr1b7 Gene Is a Common Transcriptional Target of Xenobiotic Receptors Pregnane X Receptor and Constitutive Androstane Receptor , 2009, Molecular Pharmacology.

[14]  D. Nie,et al.  Regulation of drug resistance by human pregnane X receptor in breast cancer , 2009, Cancer biology & therapy.

[15]  Xinkun Wang,et al.  Regulation of Tissue-Specific Carboxylesterase Expression by Pregnane X Receptor and Constitutive Androstane Receptor , 2009, Drug Metabolism and Disposition.

[16]  C. Klaassen,et al.  Induction of Mouse UDP-Glucuronosyltransferase mRNA Expression in Liver and Intestine by Activators of Aryl-Hydrocarbon Receptor, Constitutive Androstane Receptor, Pregnane X Receptor, Peroxisome Proliferator-Activated Receptor α, and Nuclear Factor Erythroid 2-Related Factor 2 , 2009, Drug Metabolism and Disposition.

[17]  X. Chu,et al.  Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes , 2009, Nucleic acids research.

[18]  Bruce Blumberg,et al.  Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells , 2009, BMC Cancer.

[19]  Phil Schumm,et al.  Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States. , 2008, JAMA.

[20]  R. Kim,et al.  Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer. , 2008, Cancer research.

[21]  M. Ingelman-Sundberg,et al.  Intracellular transport and localization of microsomal cytochrome P450 , 2008, Analytical and bioanalytical chemistry.

[22]  L. Moore,et al.  The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor. , 2008, Molecular endocrinology.

[23]  Jie Zhou,et al.  The antiapoptotic role of pregnane X receptor in human colon cancer cells. , 2008, Molecular endocrinology.

[24]  J. Sugatani,et al.  PPP1R16A, The Membrane Subunit of Protein Phosphatase 1β, Signals Nuclear Translocation of the Nuclear Receptor Constitutive Active/Androstane Receptor , 2008, Molecular Pharmacology.

[25]  Dale J. Kempf,et al.  A Human Immunodeficiency Virus Protease Inhibitor Is a Novel Functional Inhibitor of Human Pregnane X Receptor , 2008, Drug Metabolism and Disposition.

[26]  C. Klaassen,et al.  Regulation of Sulfotransferase Enzymes by Prototypical Microsomal Enzyme Inducers in Mice , 2008, Journal of Pharmacology and Experimental Therapeutics.

[27]  Shufeng Zhou,et al.  Multidrug resistance associated proteins as determining factors of pharmacokinetics and pharmacodynamics of drugs. , 2007, Current drug metabolism.

[28]  D. Nie,et al.  Human pregnane X receptor and resistance to chemotherapy in prostate cancer. , 2007, Cancer research.

[29]  J. Petrick,et al.  Importance of Hepatic Induction of Constitutive Androstane Receptor and Other Transcription Factors That Regulate Xenobiotic Metabolism and Transport , 2007, Drug Metabolism and Disposition.

[30]  M. Kamijima,et al.  Pyrene-induced CYP1A2 and SULT1A1 may be regulated by CAR and not by AhR. , 2007, Toxicology.

[31]  Sean Ekins,et al.  Human Pregnane X Receptor Antagonists and Agonists Define Molecular Requirements for Different Binding Sites , 2007, Molecular Pharmacology.

[32]  G. Perdew,et al.  Aryl‐hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver , 2007, Hepatology.

[33]  K. Kang,et al.  Induction of multidrug resistance associated protein 2 in tamoxifen-resistant breast cancer cells. , 2007, Endocrine-related cancer.

[34]  L. Moore,et al.  Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition. , 2007, Molecular endocrinology.

[35]  Bradley L Urquhart,et al.  Nuclear Receptors and the Regulation of Drug‐Metabolizing Enzymes and Drug Transporters: Implications for Interindividual Variability in Response to Drugs , 2007, Journal of clinical pharmacology.

[36]  Hao Li,et al.  Activated Pregnenolone X-Receptor Is a Target for Ketoconazole and Its Analogs , 2007, Clinical Cancer Research.

[37]  Denise G. Teotico,et al.  Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole , 2007, Oncogene.

[38]  B. Blumberg,et al.  The Dietary Isothiocyanate Sulforaphane Is an Antagonist of the Human Steroid and Xenobiotic Nuclear Receptor , 2007, Molecular Pharmacology.

[39]  Hongbing Wang,et al.  Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers , 2007, Journal of Pharmacology and Experimental Therapeutics.

[40]  J. Goldstein,et al.  Phenytoin Induction of the Cyp2c37 Gene Is Mediated by the Constitutive Androstane Receptor , 2006, Drug Metabolism and Disposition.

[41]  M. Nakajima,et al.  Induction of Human CYP2A6 Is Mediated by the Pregnane X Receptor with Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α , 2006, Journal of Pharmacology and Experimental Therapeutics.

[42]  C. Klaassen,et al.  Induction of Rat UDP-Glucuronosyltransferases in Liver and Duodenum by Microsomal Enzyme Inducers That Activate Various Transcriptional Pathways , 2006, Drug Metabolism and Disposition.

[43]  Olivier Fardel,et al.  Differential Regulation of Sinusoidal and Canalicular Hepatic Drug Transporter Expression by Xenobiotics Activating Drug-Sensing Receptors in Primary Human Hepatocytes , 2006, Drug Metabolism and Disposition.

[44]  Tetsuo Satoh,et al.  Structure, function and regulation of carboxylesterases. , 2006, Chemico-biological interactions.

[45]  D. Nebert.  Drug Metabolism: Evolution , 2006 .

[46]  A. Takeshita,et al.  The endocrine disrupting chemical, diethylhexyl phthalate, activates MDR1 gene expression in human colon cancer LS174T cells. , 2006, The Journal of endocrinology.

[47]  R. Evans,et al.  Anatomical Profiling of Nuclear Receptor Expression Reveals a Hierarchical Transcriptional Network , 2006, Cell.

[48]  E. Barta,et al.  Peroxisome Proliferator-activated Receptor γ-regulated ABCG2 Expression Confers Cytoprotection to Human Dendritic Cells* , 2006, Journal of Biological Chemistry.

[49]  J. Pascussi,et al.  Ketoconazole and Miconazole Are Antagonists of the Human Glucocorticoid Receptor: Consequences on the Expression and Function of the Constitutive Androstane Receptor and the Pregnane X Receptor , 2006, Molecular Pharmacology.

[50]  D. Foster,et al.  Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines. , 2006, Biochemical pharmacology.

[51]  R. Jover,et al.  Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8. , 2006, Pharmacogenomics.

[52]  L. Poellinger,et al.  Role of CYP3A4 in the regulation of the aryl hydrocarbon receptor by omeprazole sulphide. , 2006, Cellular signalling.

[53]  W. London,et al.  Association of high-level MRP1 expression with poor clinical outcome in a large prospective study of primary neuroblastoma. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[54]  A. Baum,et al.  Traditional Chinese Medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) Activate Pregnane X Receptor and Increase Warfarin Clearance in Rats , 2006, Journal of Pharmacology and Experimental Therapeutics.

[55]  M. Gottesman,et al.  Targeting multidrug resistance in cancer , 2006, Nature Reviews Drug Discovery.

[56]  Shivendra V. Singh,et al.  Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells. , 2006, Molecular endocrinology.

[57]  F. Oesch,et al.  Phosphorylation of cytochromes P450: first discovery of a posttranslational modification of a drug-metabolizing enzyme. , 2005, Biochemical and biophysical research communications.

[58]  S. Hood,et al.  Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). , 2005, Toxicology and applied pharmacology.

[59]  Alfonso Lampen,et al.  Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists. , 2005, Carcinogenesis.

[60]  C. Guillemette,et al.  Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. , 2005, Pharmacogenetics and genomics.

[61]  W. Haefeli,et al.  Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver. , 2005, Biochemical pharmacology.

[62]  F. Gonzalez-fernandez,et al.  Cancer stem cell characteristics in retinoblastoma. , 2005, Molecular vision.

[63]  S. Mani,et al.  Activation of the Steroid and Xenobiotic Receptor (Human Pregnane X Receptor) by Nontaxane Microtubule-Stabilizing Agents , 2005, Clinical Cancer Research.

[64]  J. Goldstein,et al.  Human CYP2C8 Is Transcriptionally Regulated by the Nuclear Receptors Constitutive Androstane Receptor, Pregnane X Receptor, Glucocorticoid Receptor, and Hepatic Nuclear Factor 4α , 2005, Molecular Pharmacology.

[65]  S. Sahlin,et al.  Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans. , 2005, Gastroenterology.

[66]  A. Donnenberg,et al.  Multiple Drug Resistance in Cancer Revisited: The Cancer Stem Cell Hypothesis , 2005, Journal of clinical pharmacology.

[67]  C. Klaassen,et al.  Regulation of hepatic transporters by xenobiotic receptors. , 2005, Current drug metabolism.

[68]  M. Redinbo,et al.  Structure and function of the human nuclear xenobiotic receptor PXR. , 2005, Current drug metabolism.

[69]  T. Kocarek,et al.  Regulation of sulfotransferases by xenobiotic receptors. , 2005, Current drug metabolism.

[70]  D. Mutch,et al.  Stable suppression of MDR-1 gene using siRNA expression vector to reverse drug resistance in a human uterine sarcoma cell line. , 2005, Gynecologic oncology.

[71]  Michael G. Rosenfeld,et al.  Controlling nuclear receptors: the circular logic of cofactor cycles , 2005, Nature Reviews Molecular Cell Biology.

[72]  J. Issa,et al.  Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[73]  G. Perdew,et al.  Role of the aryl hydrocarbon receptor in drug metabolism , 2005, Expert opinion on drug metabolism & toxicology.

[74]  R. Rühl.  Induction of PXR-mediated metabolism by β-carotene , 2005 .

[75]  H. Masuyama,et al.  The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion. , 2005, Molecular endocrinology.

[76]  L. Moore,et al.  Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. , 2005, Molecular endocrinology.

[77]  C. Falany,et al.  Regulation of Human Hepatic Hydroxysteroid Sulfotransferase Gene Expression by the Peroxisome Proliferator-Activated Receptor α Transcription Factor , 2005, Molecular Pharmacology.

[78]  D. Moore,et al.  Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism. , 2005, Endocrinology.

[79]  J. Sugatani,et al.  Transcriptional Regulation of Human UGT1A1 Gene Expression: Activated Glucocorticoid Receptor Enhances constitutive Androstane Receptor/Pregnane X Receptor-Mediated UDP-Glucuronosyltransferase 1A1 Regulation with Glucocorticoid Receptor-Interacting Protein 1 , 2005, Molecular Pharmacology.

[80]  C. Carlberg,et al.  Identification of pregnane X receptor binding sites in the regulatory regions of genes involved in bile acid homeostasis. , 2005, Journal of molecular biology.

[81]  J. Staudinger,et al.  Induction of Drug Metabolism by Forskolin: The Role of the Pregnane X Receptor and the Protein Kinase A Signal Transduction Pathway , 2005, Journal of Pharmacology and Experimental Therapeutics.

[82]  Georges de Sousa,et al.  A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides. , 2004, Biochemical pharmacology.

[83]  T. Sueyoshi,et al.  Cytoplasmic Localization of Pregnane X Receptor and Ligand-dependent Nuclear Translocation in Mouse Liver* , 2004, Journal of Biological Chemistry.

[84]  R. Evans,et al.  The Constitutive Androstane Receptor and Pregnane X Receptor Function Coordinately to Prevent Bile Acid-induced Hepatotoxicity* , 2004, Journal of Biological Chemistry.

[85]  P. Rogan,et al.  Development and Refinement of Pregnane X Receptor (PXR) DNA Binding Site Model Using Information Theory , 2004, Journal of Biological Chemistry.

[86]  K. Blackwell,et al.  Hypoxia and anemia: factors in decreased sensitivity to radiation therapy and chemotherapy? , 2004, The oncologist.

[87]  E. White,et al.  Epothilone induced cytotoxicity is dependent on p53 status in prostate cells , 2004, The Prostate.

[88]  F. Grün,et al.  TOCOTRIENOLS ACTIVATE THE STEROID AND XENOBIOTIC RECEPTOR, SXR, AND SELECTIVELY REGULATE EXPRESSION OF ITS TARGET GENES , 2004, Drug Metabolism and Disposition.

[89]  C. Fontaine,et al.  Genomic and non-genomic interactions of PPARα with xenobiotic-metabolizing enzymes , 2004, Trends in Endocrinology & Metabolism.

[90]  L. Moldawer,et al.  Inducible nuclear factor-κB activation contributes to chemotherapy resistance in gastric cancer1 ☆ , 2004 .

[91]  S. Khoo,et al.  Expression of Pregnane-X-Receptor Transcript in Peripheral Blood Mononuclear Cells and Correlation with Mdr1 Mrna , 2004, Antiviral therapy.

[92]  N. Tanaka,et al.  Molecular mechanism of chemoresistance to cisplatin in ovarian cancer cell lines. , 2004, International journal of molecular medicine.

[93]  J. Goldstein,et al.  The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29. , 2004, Molecular pharmacology.

[94]  R. Evans,et al.  Interactions between Hepatic Mrp4 and Sult2a as Revealed by the Constitutive Androstane Receptor and Mrp4 Knockout Mice* , 2004, Journal of Biological Chemistry.

[95]  Y. Pommier,et al.  ABCG2 overexpression in colon cancer cells resistant to SN38 and in irinotecan‐treated metastases , 2004, International journal of cancer.

[96]  T. Willson,et al.  The Nuclear Receptor CAR Is a Regulator of Thyroid Hormone Metabolism during Caloric Restriction* , 2004, Journal of Biological Chemistry.

[97]  Yves Pommier,et al.  Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks , 2004, Oncogene.

[98]  Geraldine A Hamilton,et al.  Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. , 2004, Drug metabolism and disposition: the biological fate of chemicals.

[99]  P. Pfluger,et al.  Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane X receptor , 2004, European journal of nutrition.

[100]  R. Evans,et al.  A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. , 2004, Molecular pharmacology.

[101]  J. Goldstein,et al.  Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor , 2004, Journal of Pharmacology and Experimental Therapeutics.

[102]  E. Boitier,et al.  Liver gene expression profiles of rats treated with clofibric acid: comparison of whole liver and laser capture microdissected liver. , 2003, The American journal of pathology.

[103]  Hongbing Wang,et al.  Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors. , 2003, Current drug metabolism.

[104]  S. Kliewer,et al.  Complementary Roles of Farnesoid X Receptor, Pregnane X Receptor, and Constitutive Androstane Receptor in Protection against Bile Acid Toxicity* , 2003, Journal of Biological Chemistry.

[105]  T. Sueyoshi,et al.  Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. , 2003, Molecular pharmacology.

[106]  F. Grün,et al.  Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR). , 2003, Environmental health perspectives.

[107]  K. Scotto.  Transcriptional regulation of ABC drug transporters , 2003, Oncogene.

[108]  K. Bock,et al.  Contribution of the Ah receptor to the phenolic antioxidant-mediated expression of human and rat UDP-glucuronosyltransferase UGT1A6 in Caco-2 and rat hepatoma 5L cells. , 2003, Biochemical pharmacology.

[109]  H. Masuyama,et al.  Expression and potential roles of pregnane X receptor in endometrial cancer. , 2003, The Journal of clinical endocrinology and metabolism.

[110]  F. Staedtler,et al.  Effects of clofibric acid on mRNA expression profiles in primary cultures of rat, mouse and human hepatocytes. , 2003, Toxicology and applied pharmacology.

[111]  B. Staels,et al.  Peroxisome Proliferator-activated Receptor α Induces Hepatic Expression of the Human Bile Acid Glucuronidating UDP-glucuronosyltransferase 2B4 Enzyme* , 2003, Journal of Biological Chemistry.

[112]  M. Lambert,et al.  Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. , 2003, Journal of molecular biology.

[113]  J. Goldstein,et al.  Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter. , 2003, Molecular pharmacology.

[114]  R. Evans,et al.  Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor. , 2003, Molecular endocrinology.

[115]  D. Lewis.  P450 structures and oxidative metabolism of xenobiotics. , 2003, Pharmacogenomics.

[116]  C. Klaassen,et al.  NUCLEAR RECEPTOR, PREGNANE X RECEPTOR, IS REQUIRED FOR INDUCTION OF UDP-GLUCURONOSYLTRANSFERASES IN MOUSE LIVER BY PREGNENOLONE-16α-CARBONITRILE , 2003 .

[117]  S. Auerbach,et al.  Alternatively spliced isoforms of the human constitutive androstane receptor. , 2003, Nucleic acids research.

[118]  J. Labbé,et al.  Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases Published, JLR Papers in Press, March 16, 2003. DOI 10.1194/jlr.M300010-JLR200 , 2003, Journal of Lipid Research.

[119]  L. Moore,et al.  Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes* , 2003, The Journal of Biological Chemistry.

[120]  R. Tukey,et al.  Involvement of the Xenobiotic Response Element (XRE) in Ah Receptor-mediated Induction of Human UDP-glucuronosyltransferase 1A1 * , 2003, The Journal of Biological Chemistry.

[121]  C. Guillemette,et al.  The UDP-glucuronosyltransferase 1A9 Enzyme Is a Peroxisome Proliferator-activated Receptor α and γ Target Gene* , 2003, The Journal of Biological Chemistry.

[122]  Wen Xie,et al.  Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[123]  R. Clarke,et al.  ATP binding cassette transporters and drug resistance in breast cancer. , 2003, Endocrine-related cancer.

[124]  O. Gotoh,et al.  Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR. , 2003, Molecular pharmacology.

[125]  L. Moore,et al.  2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin. , 2003, Biochemistry.

[126]  B. Staels,et al.  Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. , 2003, The Biochemical journal.

[127]  G. Perdew,et al.  The hsp90 Co-chaperone XAP2 Alters Importin β Recognition of the Bipartite Nuclear Localization Signal of the Ah Receptor and Represses Transcriptional Activity* , 2003, The Journal of Biological Chemistry.

[128]  Eric F. Johnson,et al.  Regulation of P450 4A expression by peroxisome proliferator activated receptors. , 2002, Toxicology.

[129]  G. Gibbons.  The role of cytochrome P450 in the regulation of cholesterol biosynthesis , 2002, Lipids.

[130]  X. Coumoul,et al.  PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides. , 2002, Biochemical pharmacology.

[131]  D. Moore,et al.  Modulation of Acetaminophen-Induced Hepatotoxicity by the Xenobiotic Receptor CAR , 2002, Science.

[132]  R. Evans,et al.  Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR) , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[133]  Johnson Ww.  P-glycoprotein-mediated efflux as a major factor in the variance of absorption and distribution of drugs: modulation of chemotherapy resistance. , 2002 .

[134]  C. Falany,et al.  Effects of dexamethasone on aryl (SULT1A1)- and hydroxysteroid (SULT2A1)-sulfotransferase gene expression in primary cultured human hepatocytes. , 2002, Drug metabolism and disposition: the biological fate of chemicals.

[135]  J. Goldstein,et al.  Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. , 2002, Molecular pharmacology.

[136]  S. Kliewer,et al.  Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. , 2002, Molecular pharmacology.

[137]  J. Verweij,et al.  Effects of St. John's wort on irinotecan metabolism. , 2002, Journal of the National Cancer Institute.

[138]  C. Handschin,et al.  Cholesterol and Bile Acids Regulate Xenosensor Signaling in Drug-mediated Induction of Cytochromes P450* , 2002, The Journal of Biological Chemistry.

[139]  K. Brouwer,et al.  Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital. , 2002, Drug metabolism and disposition: the biological fate of chemicals.

[140]  T. Willson,et al.  Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. , 2002, Biochemistry.

[141]  L. Moore,et al.  Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen. , 2002, Drug metabolism and disposition: the biological fate of chemicals.

[142]  Karsten Kristiansen,et al.  Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation. , 2002, The Biochemical journal.

[143]  C. Klaassen,et al.  Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor. , 2002, Molecular pharmacology.

[144]  T. Willson,et al.  Pxr, car and drug metabolism , 2002, Nature Reviews Drug Discovery.

[145]  R. Weber,et al.  Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[146]  P. Krammer,et al.  Upregulation of bcl‐2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines , 2002, International journal of cancer.

[147]  Paul T Tarr,et al.  Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor* , 2002, The Journal of Biological Chemistry.

[148]  J. Pascussi,et al.  Transcriptional Regulation of CYP2C9 Gene , 2002, The Journal of Biological Chemistry.

[149]  Y. Liu,et al.  Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. , 2001, Drug metabolism and disposition: the biological fate of chemicals.

[150]  B. Jaber,et al.  Interaction between cyclosporine and Hypericum perforatum (St. John's wort) after organ transplantation. , 2001, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[151]  A. Fugh-Berman,et al.  Herb-drug interactions: review and assessment of report reliability. , 2001, British journal of clinical pharmacology.

[152]  N. Plant,et al.  Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers. , 2001, Drug metabolism and disposition: the biological fate of chemicals.

[153]  Jatinder Lamba,et al.  Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction among Nuclear Hormone Receptors, Transporters, and Cytochrome P450* , 2001, The Journal of Biological Chemistry.

[154]  W. Xie,et al.  Orphan Nuclear Receptors: The Exotics of Xenobiotics* , 2001, The Journal of Biological Chemistry.

[155]  A. Takeshita,et al.  Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription. , 2001, European journal of endocrinology.

[156]  B. M. Forman,et al.  Peptide Mimetic HIV Protease Inhibitors Are Ligands for the Orphan Receptor SXR* , 2001, The Journal of Biological Chemistry.

[157]  R. Prough,et al.  Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: involvement of both the glucocorticoid and pregnane X receptors. , 2001, Molecular pharmacology.

[158]  J Verweij,et al.  Clinical pharmacokinetics and metabolism of irinotecan (CPT-11). , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[159]  L. Moore,et al.  The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity , 2001, Science.

[160]  Oliver Burk,et al.  Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin* , 2001, The Journal of Biological Chemistry.

[161]  P. Guzelian,et al.  Cyp3A regulation: from pharmacology to nuclear receptors. , 2001, Drug metabolism and disposition: the biological fate of chemicals.

[162]  P. Elliott,et al.  Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition. , 2001, Cancer research.

[163]  B. M. Forman,et al.  The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux , 2001, Nature Medicine.

[164]  J. Sugatani,et al.  The phenobarbital response enhancer module in the human bilirubin UDP‐glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR , 2001, Hepatology.

[165]  T. Willson,et al.  The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[166]  J. Beijnen,et al.  Drug interaction between St John's wort and nevirapine. , 2001, AIDS.

[167]  G. Perdew,et al.  Subcellular Localization of the Aryl Hydrocarbon Receptor Is Modulated by the Immunophilin Homolog Hepatitis B Virus X-associated Protein 2* , 2000, The Journal of Biological Chemistry.

[168]  P. Guzelian,et al.  Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. , 2000, Genes & development.

[169]  M. Hunt,et al.  The Peroxisome Proliferator-activated Receptor α (PPARα) Regulates Bile Acid Biosynthesis* , 2000, The Journal of Biological Chemistry.

[170]  L. Moore,et al.  A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. , 2000, Molecular cell.

[171]  B. Neuschwander‐Tetri,et al.  Humanized xenobiotic response in mice expressing nuclear receptor SXR , 2000, Nature.

[172]  L. Moore,et al.  St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[173]  L. Moore,et al.  Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands* , 2000, The Journal of Biological Chemistry.

[174]  D. Moore,et al.  The Xenobiotic Compound 1,4-Bis[2-(3,5-Dichloropyridyloxy)]Benzene Is an Agonist Ligand for the Nuclear Receptor CAR , 2000, Molecular and Cellular Biology.

[175]  D. Waxman,et al.  Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide. , 2000, Biochemical pharmacology.

[176]  M. Negishi,et al.  Regulation of cytochrome P450 (CYP) genes by nuclear receptors. , 2000, The Biochemical journal.

[177]  J. Newman,et al.  Triclosan: a review of effectiveness and safety in health care settings. , 2000, American journal of infection control.

[178]  J. Chiang,et al.  Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription. , 2000, Journal of lipid research.

[179]  M. Kunitomi,et al.  Endocrine disrupting chemicals, phthalic acid and nonylphenol, activate Pregnane X receptor-mediated transcription. , 2000, Molecular endocrinology.

[180]  C. Glass,et al.  The coregulator exchange in transcriptional functions of nuclear receptors. , 2000, Genes & development.

[181]  P. Watkins,et al.  THE HUMAN CYP3A SUBFAMILY: PRACTICAL CONSIDERATIONS* , 2000, Drug metabolism reviews.

[182]  T. Kocarek,et al.  Regulation of rat hepatic hydroxysteroid sulfotransferase (SULT2-40/41) gene expression by glucocorticoids: evidence for a dual mechanism of transcriptional control. , 1999, Molecular pharmacology.

[183]  V. Giguère,et al.  Orphan nuclear receptors: from gene to function. , 1999 .

[184]  M. Minemura,et al.  Overexpression of multidrug resistance genes MDR1 and cMOAT in human hepatocellular carcinoma and hepatoblastoma cell lines. , 1999, International journal of oncology.

[185]  H. Zhang,et al.  Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation. , 1999, Archives of biochemistry and biophysics.

[186]  Helmut Dotzlaw,et al.  The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[187]  J. Lehmann,et al.  Bile acids: natural ligands for an orphan nuclear receptor. , 1999, Science.

[188]  L. Poellinger,et al.  Evidence That the Co-chaperone p23 Regulates Ligand Responsiveness of the Dioxin (Aryl Hydrocarbon) Receptor* , 1999, The Journal of Biological Chemistry.

[189]  Neil J McKenna,et al.  A Steroid Receptor Coactivator, SRA, Functions as an RNA and Is Present in an SRC-1 Complex , 1999, Cell.

[190]  L. Freedman.  Increasing the Complexity of Coactivation in Nuclear Receptor Signaling , 1999, Cell.

[191]  Paavo Honkakoski,et al.  The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene* , 1999, The Journal of Biological Chemistry.

[192]  L. Doyle,et al.  Erratum: A multidrug resistance transporter from human MCF-7 breast cancer cells (Proceedings of the National Academy of Sciences of the USA (December 22, 1998) 95 (15665-15670)) , 1999 .

[193]  T. Sakuma,et al.  Induction of CYP1A2 by phenobarbital in the livers of aryl hydrocarbon-responsive and -nonresponsive mice. , 1999, Drug metabolism and disposition: the biological fate of chemicals.

[194]  L. Doyle,et al.  A multidrug resistance transporter from human MCF-7 breast cancer cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[195]  R. Evans,et al.  Orphan nuclear receptors--new ligands and new possibilities. , 1998, Genes & development.

[196]  W. Sabbagh,et al.  SXR, a novel steroid and xenobiotic-sensing nuclear receptor. , 1998, Genes & development.

[197]  R Ohlsson,et al.  Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[198]  David D. Moore,et al.  Androstane metabolites bind to and deactivate the nuclear receptor CAR-β , 1998, Nature.

[199]  T. Sueyoshi,et al.  The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene , 1998, Molecular and Cellular Biology.

[200]  J. Lehmann,et al.  The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. , 1998, The Journal of clinical investigation.

[201]  R. Hammer,et al.  Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα , 1998, Cell.

[202]  J. V. Vanden Heuvel,et al.  Hepatitis B Virus X-Associated Protein 2 Is a Subunit of the Unliganded Aryl Hydrocarbon Receptor Core Complex and Exhibits Transcriptional Enhancer Activity , 1998, Molecular and Cellular Biology.

[203]  G. Giaccone,et al.  CPT-11 sensitivity in relation to the expression of P170-glycoprotein and multidrug resistance-associated protein. , 1998, British Journal of Cancer.

[204]  J. Lehmann,et al.  An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway , 1998, Cell.

[205]  Elizabeth Landrum Michalets,et al.  Update: Clinically Significant Cytochrome P‐450 Drug Interactions , 1998, Pharmacotherapy.

[206]  W. Wahli,et al.  Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. , 1997, Molecular endocrinology.

[207]  J. Gustafsson,et al.  Aryl hydrocarbon receptor-mediated signal transduction. , 1997, Critical reviews in toxicology.

[208]  Timothy M. Willson,et al.  Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway* , 1997, The Journal of Biological Chemistry.

[209]  F. Lombardo,et al.  Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings , 1997 .

[210]  M. Hsu,et al.  The Peroxisome Proliferator‐Activated Receptor: Transcriptional Activation of the CYP4A6 Gene a , 1996, Annals of the New York Academy of Sciences.

[211]  C. Ioannides.  Cytochromes P450 Metabolic and Toxicological Aspects , 1996 .

[212]  S. Aebi,et al.  The role of DNA mismatch repair in platinum drug resistance. , 1996, Cancer research.

[213]  K. Griffin,et al.  Role of the peroxisome proliferator‐activated receptor in cytochrome P450 4A gene regulation , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[214]  T. Iyanagi,et al.  Xenobiotic Responsive Element-mediated Transcriptional Activation in the UDP-glucuronosyltransferase Family 1 Gene Complex (*) , 1996, The Journal of Biological Chemistry.

[215]  S. Ménard,et al.  A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma. , 1996, Cancer research.

[216]  P. Neuvonen,et al.  Rifampin drastically reduces plasma concentrations and effects of oral midazolam , 1996, Clinical pharmacology and therapeutics.

[217]  A. Li,et al.  Substrates of human hepatic cytochrome P450 3A4. , 1995, Toxicology.

[218]  R. Evans,et al.  The RXR heterodimers and orphan receptors , 1995, Cell.

[219]  K. Umesono,et al.  The nuclear receptor superfamily: The second decade , 1995, Cell.

[220]  J. Hinson,et al.  Phase II enzymes and bioactivation. , 1995, Canadian journal of physiology and pharmacology.

[221]  Eric F. Johnson,et al.  Novel Sequence Determinants in Peroxisome Proliferator Signaling (*) , 1995, The Journal of Biological Chemistry.

[222]  William Bourguet,et al.  Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α , 1995, Nature.

[223]  T. Pineau,et al.  Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators , 1995, Molecular and cellular biology.

[224]  R. Hiipakka,et al.  Ubiquitous Receptor: Structures, Immunocytochemical Localization, and Modulation of Gene Activation by Receptors for Retinoic Acids and Thyroid Hormones a , 1995, Annals of the New York Academy of Sciences.

[225]  K. Umesono,et al.  LXR, a nuclear receptor that defines a distinct retinoid response pathway. , 1995, Genes & development.

[226]  S. Green,et al.  Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription. , 1995, The Biochemical journal.

[227]  S. Bates,et al.  Chemoresistance in the clinic: overview 1994. , 1994, Bulletin du cancer.

[228]  K. Henle,et al.  Tumor drug-resistance: a challenge to therapists and biologists. , 1994, The American journal of the medical sciences.

[229]  D. Moore,et al.  A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements , 1994, Molecular and cellular biology.

[230]  R. Tukey,et al.  Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: transcriptional activation of the human CYP1A1 gene. , 1993, Molecular pharmacology.

[231]  D. Russell,et al.  Structure of the rat gene encoding cholesterol 7α-hydroxylase , 1990 .

[232]  J. Chiang,et al.  Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA. , 1990, The Journal of biological chemistry.

[233]  J. Goldstein,et al.  Regulation of the mevalonate pathway , 1990, Nature.

[234]  G. Perdew.  Association of the Ah receptor with the 90-kDa heat shock protein. , 1988, The Journal of biological chemistry.

[235]  M. Brown,et al.  A receptor-mediated pathway for cholesterol homeostasis. , 1986, Science.

[236]  D. Nie,et al.  Pregnane X receptor and its potential role in drug resistance in cancer treatment. , 2009, Recent patents on anti-cancer drug discovery.

[237]  C. Klaassen,et al.  Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2. , 2008, Toxicology and applied pharmacology.

[238]  T. Matsubara,et al.  Broad but distinct role of pregnane x receptor on the expression of individual cytochrome p450s in human hepatocytes. , 2007, Drug metabolism and pharmacokinetics.

[239]  B. Blumberg,et al.  Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma. , 2006, Cancer research.

[240]  M. Eichelbaum,et al.  A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression , 2005, Biological chemistry.

[241]  A. Jemal,et al.  Cancer Statistics, 2005 , 2005, CA: a cancer journal for clinicians.

[242]  H. McLeod,et al.  Lessons learned from the irinotecan metabolic pathway. , 2003, Current medicinal chemistry.

[243]  Hongbing Wang,et al.  Role of Orphan Nuclear Receptors in the Regulation of Drug-Metabolising Enzymes , 2003, Clinical pharmacokinetics.

[244]  D. Moore,et al.  Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response , 2002, The Pharmacogenomics Journal.

[245]  M. Redinbo,et al.  Structural insights into the promiscuity and function of the human pregnane X receptor. , 2002, Current opinion in drug discovery & development.

[246]  J. Boyer,et al.  Mechanisms of Hepatic Transport of Drugs: Implications for Cholestatic Drug Reactions , 2002, Seminars in liver disease.

[247]  Sean Ekins,et al.  A pharmacophore for human pregnane X receptor ligands. , 2002, Drug metabolism and disposition: the biological fate of chemicals.

[248]  J. Lehmann,et al.  Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. , 2002, Molecular pharmacology.

[249]  H. Masuyama,et al.  Ligands have various potential effects on the degradation of pregnane X receptor by proteasome. , 2002, Endocrinology.

[250]  B. M. Forman,et al.  The nuclear receptor PXR: a master regulator of "homeland" defense. , 2002, Critical reviews in eukaryotic gene expression.

[251]  T. Sueyoshi,et al.  Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. , 2001, Annual review of pharmacology and toxicology.

[252]  J. Hogenesch,et al.  The PAS superfamily: sensors of environmental and developmental signals. , 2000, Annual review of pharmacology and toxicology.

[253]  R. Tukey,et al.  Human UDP-glucuronosyltransferases: metabolism, expression, and disease. , 2000, Annual review of pharmacology and toxicology.

[254]  Y. Sugiyama,et al.  Transport of Drugs Across the Hepatic Sinusoidal Membrane: Sinusoidal Drug Influx and Efflux in the Liver , 2000, Seminars in liver disease.

[255]  L. Moore,et al.  The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution , 2000 .

[256]  I. Pastan,et al.  Biochemical, cellular, and pharmacological aspects of the multidrug transporter. , 1999, Annual review of pharmacology and toxicology.

[257]  F. Guengerich,et al.  Cytochrome P-450 3A4: regulation and role in drug metabolism. , 1999, Annual review of pharmacology and toxicology.

[258]  W. Wahli,et al.  Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. , 1996, Endocrinology.

[259]  O. MacDougald,et al.  Transcriptional regulation of gene expression during adipocyte differentiation. , 1995, Annual review of biochemistry.

[260]  M. J. Coon,et al.  The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. , 1993, DNA and cell biology.

[261]  O. Hankinson,et al.  Genetic and molecular analysis of the Ah receptor and of Cyp1a1 gene expression. , 1991, Biochimie.