Epstein Barr Virus (EBV) Fusion with Hepathoma Cell Line (Li7A): A Possibility to Use Ebv Virosohes for Drugs Delivery to Liver Cells

AbstractEBV a causative agent of mononucleosis and several human cancers, infects cell via complement receptor type 2 (CR2). Expression of this receptor is restricted to B lymphocytes, some epithelial cells and immature thymocytes, expression of CR2 like proteins has been also found on T cells. In the present report we identified the presence on the membrane of Li7A cells of a novel EBV receptor distinct from CR2 capable to trigger fusion with EBV virions with a kinetics faster than that found with lymphoblastoid cells (Raji).

[1]  M. Clementi,et al.  Co-amplification of transcriptionally active epidermal growth factor receptor and ribosomal genes in the human hepatoma cell line Li7A. , 1992, Oncogene.

[2]  G. Nemerow,et al.  Inhibition of Epstein-Barr virus infection in vitro and in vivo by soluble CR2 (CD21) containing two short consensus repeats , 1991, Journal of virology.

[3]  S. Grimaldi,et al.  Effect of erythrocyte transbilayer phospholipid distribution on fusion with vesicular stomatitis virus. , 1990, Biochemistry.

[4]  N. Miller,et al.  A monoclonal antibody to glycoprotein gp85 inhibits fusion but not attachment of Epstein-Barr virus , 1988, Journal of virology.

[5]  V. Baichwal,et al.  Latency comes of age for herpesviruses , 1988, Cell.

[6]  S. Grimaldi,et al.  Calcium modulation activates Epstein-Barr virus genome in latently infected cells. , 1986, Science.

[7]  P. A. Biro,et al.  Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[8]  G. Nemerow,et al.  Early events in the infection of human B lymphocytes by Epstein-Barr virus: the internalization process. , 1984, Virology.

[9]  G. Klein,et al.  Two large virion envelope glycoproteins mediate Epstein-Barr virus binding to receptor-positive cells , 1982, Journal of virology.

[10]  G. Lenoir,et al.  Replication of Epstein-Barr virus: ultrastructural and immunofluorescent studies of P3HR1-superinfected Raji cells , 1977, Journal of virology.

[11]  W. Henle,et al.  Differential Reactivity of Human Serums with Early Antigens Induced by Epstein-Barr Virus , 1970, Science.

[12]  M. Epstein,et al.  VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA. , 1964, Lancet.