Evaluation of three preparations of etomidate.

Three formulations of etomidate were evaluated in unpremedicated patients undergoing minor gynaecological procedures. There was a high frequency of pain on injection (up to 50%) and excitatory phenomena (up to 95%) with all formulations. The frequency of excitatory phenomena was significantly greater than that after methohexitone. Recovery was rapid, but emetic sequelae were frequent and significantly more marked than after methohexitone.

[1]  E. M. Allen,et al.  Methohexitone-induced convulsions in epileptics. , 1979, Anaesthesia and intensive care.

[2]  M. Ghoneim,et al.  Etomidate: A Clinical and Electroencephalographic Comparison with Thiopental , 1977, Anesthesia and analgesia.

[3]  G. Corssen,et al.  Etomidate: An Ultrashort‐Acting Nonbarbiturate Agent for Anesthesia Induction , 1976 .

[4]  B. Kay.  A dose-response relationship for etomidate, with some observations on cumulation. , 1976, British journal of anaesthesia.

[5]  B. Kay.  A clinical assessment of the use of etomidate in children. , 1976, British journal of anaesthesia.

[6]  J. Whitwam,et al.  Effect of dose and premedication on induction complications with etomidate. , 1976, British journal of anaesthesia.

[7]  J. Whitwam,et al.  ETOMIDATE, A NEW WATER-SOLUBLE NON-BARBITURATE INTRAVENOUS INDUCTION AGENT , 1975, The Lancet.

[8]  J. Dundee,et al.  Clinical studies of induction agents. XLII: Influence of injection rate and dosage on the induction complications with Althesin. , 1973, British journal of anaesthesia.

[9]  W. Lorenz,et al.  Histamine release after intravenous application of short-acting hypnotics. A comparison of etomidate, Althesin (CT1341) and propanidid. , 1973, British journal of anaesthesia.

[10]  J. Uppington.  Epileptiform convulsion with Althesin , 1973, Anaesthesia.

[11]  J. Dundee,et al.  Clinical studies of induction agents. XXXIX: CT1341, a new steroid anaesthetic. , 1971, British journal of anaesthesia.

[12]  C. Niemegeers,et al.  Etomidate, R-(+)-ethyl-1-( -methyl-benzyl)imidazole-5-carboxylate (R 16659), a potent, short-acting and relatively atoxic intravenous hypnotic agent in rats. , 1971, Arzneimittel-Forschung.

[13]  D. Rowlands.  Pain after methohexitone , 1969 .

[14]  D. Barron.  Clinical Studies of Induction Agents XXII: Effect of Rate of Injection on Incidence of Side Effects with Thiopental and Methohexital , 1968 .

[15]  J. Dundee,et al.  CLINICAL STUDIES OF INDUCTION AGENTS. VII: A COMPARISON OF EIGHT INTRAVENOUS ANAESTHETICS AS MAIN AGENTS FOR A STANDARD OPERATION. , 1963, British journal of anaesthesia.

[16]  J. Dundee.  CLINICAL STUDIES OF INDUCTION AGENTS III: THE RELATIONSHIP BETWEEN DURATION OF ANAESTHESIA AND DOSAGE WITH G.29.505 , 1962 .

[17]  W. Mushin.  Intravenous anaesthesia. , 1948, The Practitioner.

[18]  CLINICAL STUDIES OF INDUCTION AGENTS , 2022 .