A patient with four metachronous cancers and multiple adenomatous colon polyps harboring the American Founder Lynch syndrome mutation: a case report

[1]  H T Lynch,et al.  Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications , 2009, Clinical genetics.

[2]  E. Steyerberg,et al.  Phenotype Comparison of MLH1 and MSH2 Mutation Carriers in a Cohort of 1,914 Individuals Undergoing Clinical Genetic Testing in the United States , 2008, Cancer Epidemiology Biomarkers & Prevention.

[3]  J. Mecklin,et al.  The risk of extra‐colonic, extra‐endometrial cancer in the Lynch syndrome , 2008, International journal of cancer.

[4]  Shuying Sun,et al.  Origins and prevalence of the American Founder Mutation of MSH2. , 2008, Cancer research.

[5]  S. Thibodeau,et al.  Characterization of hMLH1 and hMSH2 gene dosage alterations in Lynch syndrome patients. , 2005, Gastroenterology.

[6]  A. de la Chapelle,et al.  Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene. , 2003, American journal of human genetics.

[7]  P. Møller,et al.  MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[8]  H. Lynch,et al.  Colorectal and extracolonic cancer variations in MLH1/MSH2 hereditary nonpolyposis colorectal cancer kindreds and the general population , 1998, Diseases of the colon and rectum.