Comparison of the effects of imipramine and desipramine on single cortical neurones.

Raphe. neurones were not unique among midline midbrain neurones in being depressed by 5-HT. However their sensitivity, as measured in terms of the average recovery time, appeared greater than other midbrain units. Although only a very small number of cells were tested, raphe neurones did not respond to noradrenaline with excitation as had previously been reported in cats. However, the finding that raphe neurones are selectively depressed by lysergic acid diethylamide, is in agreement with the findings of Aghajanian et al. (1972).

[1]  J. L. Johnson,et al.  Glutamic acid as a synaptic transmitter in the nervous system. A review. , 1972, Brain research.

[2]  N. Osborne,et al.  Distribution of GABA and other amino acids in different tissues of the gastropod mollusc Helix pomatia, including in vitro experiments with 14 C glucose and 14 C glutamic acid. , 1971, The International journal of neuroscience.

[3]  C. Bradshaw,et al.  Effect of tricyclic antidepressants on monoamine responses of single cortical neurones. , 1971, British journal of pharmacology.

[4]  J. R. Couch.  Responses of neurons in the raphe nuclei to serotonin, norepinephrine and acetylcholine and their correlation with an excitatory synaptic input. , 1970, Brain research.

[5]  G. Johnston,et al.  Glutamate and related amino-acids in cat, dog, and rat spinal roots. , 1970, Comparative and general pharmacology.

[6]  S. Ross,et al.  Inhibition of the uptake of tritiated 5-hydroxytryptamine in brain tissue. , 1969, European journal of pharmacology.

[7]  T. Hökfelt,et al.  Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4,alpha-dimethyl-meta-tyramine. , 1969, European journal of pharmacology.

[8]  R. Lasek.  Axoplasmic transport in cat dorsal root ganglion cells: as studied with [3-H]-L-leucine. , 1968, Brain research.

[9]  N. Saunders,et al.  The distribution of acetylcholine in normal and in regenerating nerves , 1967, The Journal of physiology.

[10]  L. Gyermek,et al.  INFLUENCE OF IMIPRAMINE AND RELATED PSYCHOACTIVE AGENTS ON THE EFFECT OF 5-HYDROXYTRYPTAMINE AND CATECHOLAMINES ON THE CAT NICTITATING MEMBRANE. , 1963, The Journal of pharmacology and experimental therapeutics.